133 results match your criteria: "Gastroenterology Unit Fondazione-IRCCS "Casa Sollievo della Sofferenza" Hospital[Affiliation]"
Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review.
J Viral Hepat
August 2018
Division of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland.
It remains unclear whether hepatitis B virus (HBV) infection may modify the severity of viral steatosis in patients coinfected with chronic hepatitis C virus (HCV). We examined the influence of coinfection with HBV on prevalence of steatosis in chronic hepatitis C in a multi-centre cohort of HBV-HCV subjects, and by performing a systematic review and meta-analysis of the literature. We centrally and blindly assessed steatosis prevalence and severity in a cohort of HBV-HCV coinfected subjects compared to HCV and HBV monoinfected controls and we performed a systematic review of studies addressing the prevalence of steatosis in HBV-HCV subjects compared to HCV controls.
View Article and Find Full Text PDFTowards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.
BMJ Open
November 2016
Institute of Cardiovascular Research Royal Holloway, University of London (ICR2UL), London, UK.
Article Synopsis
- * The international biobank called BEAST is being established to study the genetic factors of CVT, aiming to recruit diverse cases and perform a genome-wide association analysis to identify genetic variants linked to CVT risk.
- * The study follows ethical standards and plans to share findings through peer-reviewed journals and presentations, contributing valuable insights into the mechanisms of this uncommon disease for future research.
Disease patterns in late-onset ulcerative colitis: Results from the IG-IBD "AGED study".
Dig Liver Dis
January 2017
IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy.
Background: Late-onset UC represents an important issue for the near future, but its outcomes and relative therapeutic strategies are yet poorly studied.
Aim: To better define the natural history of late-onset ulcerative colitis.
Methods: In a multicenter retrospective study, we investigated the disease presentation and course in the first 3 years in 1091 UC patients divided into 3 age-groups: diagnosis ≥65years, 40-64 years, and <40years.
Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21.
Oncotarget
October 2016
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Article Synopsis
- Genome-wide association studies (GWAS) have pinpointed 13 chromosomal locations linked to pancreatic cancer susceptibility in European individuals, and additional research has uncovered three new risk variants through extensive genetic analysis.
- The new single nucleotide polymorphisms (SNPs) identified are rs2816938, rs10094872, and rs35226131, associated with increased or decreased risk of pancreatic cancer, with significant odds ratios and p-values.
- Investigation of gene expression from these risk loci in both normal and cancerous pancreatic tissue revealed a significant reduction of NR5A2 expression in tumors, suggesting a potential target for further research into pancreatic cancer biology.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy
October 2016
kb Emory University, School of Medicine, Department of Microbiology and Immunology , Atlanta , GA , USA.
Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis.
PLoS One
May 2016
Medizinische Hochschule Hannover, Hannover, Germany.
Background: Liver stiffness determined by transient elastography is correlated with hepatic fibrosis stage and has high accuracy for detecting severe fibrosis and cirrhosis in chronic hepatitis C patients. We evaluated the clinical value of baseline FibroScan values for the prediction of safety and efficacy of telaprevir-based therapy in patients with advanced fibrosis and cirrhosis in the telaprevir Early Access Program HEP3002.
Methods: 1,772 patients with HCV-1 and bridging fibrosis or cirrhosis were treated with telaprevir plus pegylated interferon-α and ribavirin (PR) for 12 weeks followed by PR alone, the total treatment duration depending on virological response and previous response type.
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
Nat Genet
September 2014
1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.
View Article and Find Full Text PDFConstipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation.
United European Gastroenterol J
April 2014
Department of Clinical and Experimental Medicine, Federico II University Hospital School of Medicine, Naples, Italy.
Objective: We sought to evaluate the association between constipation severity, productivity losses and healthcare utilization in a national sample of Italian patients with chronic non-organic constipation (CC).
Methods: We enrolled 878 outpatients with CC. Clinical and demographic data were collected by physicians during clinical examinations.