2,109 results match your criteria: "Gastrinoma"
Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms.
Int J Cancer
November 2024
OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Article Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can be either hormone-secreting or non-secreting, have serious health implications, and an average survival of 75-124 months.
- Research shows that key genes involved in the tumor's development, especially epigenetic regulators like MEN1, DAXX, and ATRX, are often mutated, but their effects are not well understood.
- The calcium sensing receptor (CaSR) is significantly reduced in GEP-NETs, potentially due to DNA methylation and chromatin modifications, suggesting it functions as a tumor suppressor by inhibiting cell growth in pancreatic NETs.
Management of functional neuroendocrine tumors.
Curr Probl Cancer
October 2024
ENETS Center of Excellence, Division of Endocrinology and Metabolism, University of Iowa, 200 Hawkins Drive, Room E400 GH, Iowa City, Iowa, 52242, USA. Electronic address:
Article Synopsis
- * Managing the symptoms associated with functional NENs may require approaches like tumor removal, chemotherapy, or specialized therapies aimed at reducing hormone production and its effects on the body.
- * This review emphasizes the importance of addressing the hormonal symptoms of NENs alongside traditional tumor reduction strategies to enhance the overall wellbeing of patients.
Expression profiles of cadherin 17 and claudin 18.2 in comparison with peptide hormonal expression in pancreatic neuroendocrine tumours: Implications for targeted immunotherapy.
Pathol Res Pract
October 2024
Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, Matsumoto, Japan; Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, Matsumoto, Japan. Electronic address:
Cadherin 17 (CDH17) and claudin 18.2 (CLDN18.2) are highly selective markers of intestinal and gastric lineages and are expressed in adenocarcinomas of various organs.
View Article and Find Full Text PDFPancreatic masses in children: a single-center experience over two decades.
Eur J Pediatr
October 2024
Division of Pediatric General Surgery, Stanford University, Palo Alto, CA, USA.
Unlabelled: Pancreatic masses are extremely rare in pediatric patients, with limited data available. This lack of data makes the diagnosis and management of these tumors in children extremely challenging. Therefore, we aimed to describe the presentations, clinical course, and outcomes of children with pancreatic tumors at our center.
View Article and Find Full Text PDFCharacteristics, therapy, and outcome of rare functioning pancreatic neuroendocrine neoplasms.
Sci Rep
August 2024
Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Philipps University Marburg, Marburg, Germany.
Article Synopsis
- * Out of 216 patients with pNENs treated from 2002 to 2022, 12 were identified as rf-pNENs, including different subtypes like vasoactive intestinal polypeptide, glucagon, and calcitonin-producing tumours.
- * Following surgery, most patients showed positive outcomes, with a median follow-up of 75 months indicating that those who had complete resections (R0) and no liver metastases had a better prognosis, with six patients remaining alive and disease-free.
A Concept for Preoperative and Intraoperative Molecular Imaging and Detection for Assessing Extent of Disease of Solid Tumors.
Oncol Rev
July 2024
Actis Medical, LLC, Powell, OH, United States.
The authors propose a concept of "systems engineering," the approach to assessing the extent of diseased tissue (EODT) in solid tumors. We modeled the proof of this concept based on our clinical experience with colorectal carcinoma (CRC) and gastrinoma that included short and long-term survival data of CRC patients. This concept, applicable to various solid tumors, combines resources from surgery, nuclear medicine, radiology, pathology, and oncology needed for preoperative and intraoperative assessments of a patient's EODT.
View Article and Find Full Text PDFA cross-species transcriptomic analysis reveals a novel 2-dimensional classification system explaining the invasiveness heterogeneity of pancreatic neuroendocrine tumor.
Cancer Lett
July 2024
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. Electronic address:
Article Synopsis
- Pancreatic neuroendocrine tumors (PanNETs) show a wide range of invasiveness, and existing genomic knowledge sheds some light on this variability, especially between different types like insulinomas and other PanNET variants.
- Researchers used a 2D classification system based on RNA sequencing of PanNETs from both mouse models and humans to categorize these tumors primarily into benign insulinomas and various invasive subtypes.
- By integrating the 2D classification, specific mutation status (DAXX/ATRX), and tumor size, they identified a subset of PanNETs with low recurrence risk, helping to clarify the complexity of these tumors and enhance their prognostic evaluation.
Management of Pancreatic Neuroendocrine Tumors: Surgical Strategies and Controversies.
Endocr Pract
October 2024
Division of Surgical Oncology, Eastern Virginia Medical School, Norfolk, Virginia.
Article Synopsis
- Pancreatic neuroendocrine tumors (PNETs) are rare but increasingly common, and their surgical management is evolving.
- Recent studies highlight that surgery is crucial for treating both functional and nonfunctional PNETs, with a shift toward less invasive techniques for selected cases.
- Advanced disease has complicated surgical options, as new therapies are emerging, but optimal treatment plans, including the role of surgery, are still unclear and require a skilled multidisciplinary approach.
Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.
Int J Mol Sci
July 2024
Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.
Article Synopsis
- * A study of 175 ZES patients showed that 21% had vitamin B deficiency after an average of 10.2 years of treatment, particularly correlating with extremely low acid control rates.
- * The findings indicate that chronic PPI use results in significant acid reduction, which negatively impacts vitamin B levels and body stores, increasing the risk of deficiency.
Presentation, Diagnosis, and Treatment of a Sporadic Gastrinoma With Liver Metastases.
Cureus
May 2024
General Surgery, Brookdale University Hospital Medical Center, Brooklyn, USA.
Article Synopsis
- - A gastrinoma is a rare but serious tumor that produces gastrin, which can cause symptoms like anemia, weight loss, and diarrhea, complicating early detection.
- - These tumors often spread to the liver, and surgery is typically necessary to remove both the primary tumor and any metastases for a chance at a cure.
- - This report discusses a case involving a 59-year-old woman with anemia and gastrointestinal bleeding, revealing a pancreatic gastrinoma with extensive liver metastases, along with the treatment approach taken to improve her survival odds.
Diagnostics and Imaging for Pancreatic Neuroendocrine Tumors.
Surg Clin North Am
August 2024
Division of General Surgery and Surgical Oncology, Department of Surgery, University of Chicago Medicine, 5841 South Maryland Avenue, MC 4052, Chicago, IL 60637, USA. Electronic address:
Pancreatic neuroendocrine tumors originate from hormone-producing islet cells and have a propensity to metastasize to the liver once they reach 2 cm in size. Their diagnosis relies upon a combination of computed tomography, MRI, DOTATATE PET, and endoscopic ultrasound with or without tissue biopsy. Biochemical work-up is driven by patient symptoms of hormone excess.
View Article and Find Full Text PDFMiddle-segment preserving pancreatectomy: a literature review and case report.
Langenbecks Arch Surg
June 2024
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Article Synopsis
- Middle segment-preserving pancreatectomy (MSPP) is a newer surgical option for treating benign and borderline pancreatic diseases, offering an alternative to total pancreatectomy (TP), with only 36 reported cases so far.
- In a case study of a 49-year-old man with Zollinger-Elison syndrome, MSPP was successfully performed, resulting in a postoperative pancreatic fistula that improved with conservative care, and no tumor recurrence was observed.
- Although MSPP has a high morbidity rate (54%) primarily due to complications like pancreatic fistula, it shows low mortality rates and maintains pancreatic function similar to traditional surgeries.
A Case of a Metastatic Pancreatic Neuroendocrine Tumor: A Surgical Conundrum Wrapped in Functionality's Embrace.
Cureus
March 2024
First Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
This case study reports a rare case of a non-functioning metastatic pancreatic neuroendocrine tumor (pNET) transforming into a functioning pNET. A 59-year-old male, previously treated with distal pancreatectomy, splenectomy, lymph node dissection, liver metastasectomy, and pharmacotherapy, presented with weakness, hypoglycemia, and daily episodes of watery diarrhea. A functioning neuroendocrine liver metastasis expressing insulin and gastrin was identified.
View Article and Find Full Text PDFAdvancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope.
World J Gastroenterol
March 2024
Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
Article Synopsis
- The editorial discusses significant advancements in treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), focusing on personalized approaches for different tumor subtypes.
- Key treatments like cytoreductive surgery and somatostatin analogs (SSAs) are highlighted, while more aggressive options are reserved for patients unresponsive to SSAs.
- The article emphasizes the need for distinct therapies for different types of neuroendocrine tumors and suggests that understanding their genetics and exploring immunotherapies could lead to better future treatment options.
Recurrent Duodenal Ulceration-More Than Simple Peptic Ulcer Disease?
Gastroenterology
September 2024
Division of Hospital Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Sporadic gastrinoma with refractory benign esophageal stricture: A case report.
World J Clin Cases
March 2024
Department of Gastroenterology, First Affiliated Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
Article Synopsis
- - Gastrinoma leads to excess gastrin production, resulting in increased gastric acid and recurring health issues like peptic ulcers and chronic diarrhea, coupled with complications such as esophageal strictures.
- - A case study illustrates a patient with gastrinoma who faced refractory benign esophageal stricture (RBES) and complete esophageal blockage, despite various treatments aimed at reducing acid secretion.
- - Early diagnosis of gastrinoma is crucial; prolonged uncontrolled acid can significantly heighten the risk of severe esophageal strictures, making treatment options like endoscopic procedures risky and complex.
Sporadic Zollinger-Ellison syndrome in a patient with isolated mesenteric gastrinoma.
Int J Surg Case Rep
March 2024
Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger.
Article Synopsis
- * A 40-year-old patient with long-term epigastric pain and diarrhea was diagnosed with ZES after undergoing imaging and biopsy, revealing a gastrinoma.
- * Surgical removal of the gastrinoma is the most effective treatment for ZES, and early diagnosis is crucial for managing symptoms like chronic diarrhea and abdominal pain.
Neoadjuvant Peptide Receptor Radionuclide Therapy in a Rare Case of Pediatric Primary Hepatic Gastrinoma.
Clin Nucl Med
April 2024
From the Departments of Pediatric Gastroenterology and Hepatology.
Gastrinomas with predilection for the adult male population are located in the gastrinoma triangle (>90%). Primary hepatic gastrinoma especially in pediatric population is very rare. Peptide receptor radionuclide therapy has shown benefit in metastatic gastroenteropancreatic neuroendocrine tumors (NETs) with an increasing interest in expanding its role as neoadjuvant treatment modality to improve the surgical candidature in inoperable NETs.
View Article and Find Full Text PDFArticle Synopsis
- A 54-year-old man with obesity, hypertension, and a long history of abdominal pain underwent various medical tests over 12 years, revealing multiple ulcers but no clear diagnosis initially.
- In 2022, he was diagnosed with gastrinoma, a type of neuroendocrine tumor, after advanced imaging techniques identified a lesion not visible on CT scans.
- The report emphasizes the need to consider neuroendocrine tumors in similar cases and supports using 68Ga-DOTATOC PET/CT scans over older imaging methods for accurate diagnosis.
Primary gastrinoma of the gallbladder: a case report and review of the literature.
Front Oncol
January 2024
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.
Article Synopsis
- Primary gallbladder gastrinoma is a rarely reported neuroendocrine tumor, with no known prior cases documented in medical literature.
- A case study details a 50-year-old woman who experienced watery diarrhea and was later diagnosed with a tumor located at the gallbladder neck, confirmed during laparoscopic surgery.
- The study emphasizes the importance of immunohistochemical analysis for diagnosis and suggests that surgical removal can successfully alleviate symptoms, contributing new insights into this uncommon condition.
The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge.
Scand J Gastroenterol
May 2024
Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- * The review highlights the need for gastroenterologists to recognize the symptoms of CCKoma, which can overlap with Zollinger-Ellison syndrome, and discusses the importance of accurate CCK and gastrin testing for proper diagnosis.
- * There is a notable lack of clinical awareness regarding CCKoma syndrome, as well as misconceptions about the specificity required for diagnostic assays, hindering accurate diagnosis and treatment for affected patients
Two cases of pancreatic neuroendocrine tumors with ectopic ACTH syndrome during their disease course.
Clin J Gastroenterol
April 2024
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.
Pancreatic neuroendocrine tumors (PanNETs) are rare malignant tumors that occur in the pancreas. They are divided into functioning and non-functioning tumors based on the presence or absence of their specific hormonal hyper-expression symptoms. Adrenocorticotropic hormone (ACTH)-producing PanNETs are rare, functional tumors, and their clinical characteristics and outcomes have not been well reported.
View Article and Find Full Text PDFSpatial profiling reveals tissue-specific neuro-immune interactions in gastroenteropancreatic neuroendocrine tumors.
J Pathol
March 2024
Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Article Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are complex cancers influenced by the interaction of tumor cells with their surrounding microenvironment, necessitating the study of tumor-derived signals.
- Researchers utilized digital spatial profiling (DSP) to analyze the expression of immune and neural proteins in a variety of GEP-NETs, demonstrating that immune-related proteins may facilitate neuroendocrine differentiation and tumor growth.
- The findings indicated notable differences between gastrin-secreting and non-functional NETs, particularly in protein expression and immune cell presence, with MEN1-related tumors showing strong immune exclusion and unique neuro-immune signatures.
[Individualized approach for MEN1-associated duodenopancreatic neuroendocrine neoplasms].
Chirurgie (Heidelb)
March 2024
Klinik für Visceral‑, Thorax- und Gefäßchirurgie, Philipps Universität Marburg, 35043, Marburg, Deutschland.
Background: Multiple endocrine neoplasia type 1 (MEN1)-associated duodenopancreatic neuroendocrine neoplasms (dpNEN) represent the most frequent syndrome-associated cause of death, but the adequate treatment is sometimes considered controversial.
Objective: Presentation of possible diagnostic and therapeutic options for MEN1-associated dpNENs.
Material And Methods: In this review article retrospective case studies, expert recommendations, national and international guidelines as well as personal experiences were analyzed and evaluated.
Severe esophageal stricture after perforation and necrotizing esophagitis: unusual presentation of a duodenal gastrinoma.
J Surg Case Rep
December 2023
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Article Synopsis
- Gastrinomas are rare tumors in the pancreas or duodenum that produce excess gastrin, leading to serious gastrointestinal issues such as gastroesophageal reflux disease, peptic ulcers, and chronic diarrhea.
- A case study of a 58-year-old woman reveals that her duodenal gastrinoma resulted in severe complications, including esophageal perforation and stricture, highlighting the tumor's potential seriousness.
- Early diagnosis of gastrinomas is crucial to prevent severe outcomes, suggesting that patients with persistent gastroesophageal reflux disease should be screened for this condition, especially if they require long-term treatment.