7,243 results match your criteria: "Gardnerella"
From dysbiosis to homeostasis: Oleic acid matters in the vagina.
Cell Host Microbe
October 2024
Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Organ Failure Research, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:
Article Synopsis
- Research in Cell by Zhu et al. explores how fatty acids impact vaginal microbiota composition, which is not well understood.
- The study found that oleic acid (OA) specifically inhibits the growth of Lactobacillus iners, while encouraging the growth of Lactobacillus crispatus.
- These findings suggest potential new treatment strategies for bacterial vaginosis (BV) through the use of oleic acid.
Glutamine Attenuates Inflammation and Stimulates Amniotic Cell Proliferation in Premature Rupture of Membranes-related in vitro Models.
Reprod Sci
October 2024
Department of Obstetrics, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, 518172, China.
Premature rupture of membranes (PROM), with a prevalence of 15.3% in China, frequently results in adverse pregnancy outcomes. In this study, we aimed to identify amino acid metabolites that were differentially expressed in PROM versus healthy controls (HC) using targeted metabolomics and further explored their mechanisms of action with in vitro models.
View Article and Find Full Text PDFA Description of the THRIVE (The Study of Host-Bacterial Relationships and Immune Function in Different Vaginal Environments) Bacterial Vaginosis Observational Study.
J Obstet Gynaecol Can
December 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB.
Objectives: Bacterial vaginosis (BV) contributes to poor reproductive health and is characterized by a displacement of Lactobacillus in the vaginal microbiome. However, treatment for BV is limited to antibiotics and half of the women treated experience recurrence within a year. THRIVE (The Study of Host-Bacterial Relationships and Immune Function in Different Vaginal Environments) is a prospective study in Winnipeg, Manitoba, Canada, which is designed to capture the daily variation of the microbiome and host mucosal immunity during treatment.
View Article and Find Full Text PDFEpidemiology and risk factors for healthcare-associated maternal peripartum infections in Ukraine: results a multicenter study.
Pol Merkur Lekarski
October 2024
Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine.
Article Synopsis
- * Out of 3600 vaginal deliveries, 600 (16.7%) cases of maternal peripartum infections were recorded, predominantly occurring after hospital discharge, with endometritis being the most prevalent infection.
- * Key risk factors identified for these infections included high body mass index, placenta previa, prolonged rupture of membranes, and various pregnancy-related conditions.
The cAMP receptor protein from Gardnerella vaginalis is not regulated by ligands.
Commun Biol
October 2024
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, PR China.
Overgrowth of Gardnerella vaginalis causes an imbalance in vaginal microecology. The pathogenicity of G. vaginalis is directly regulated by the cAMP receptor protein (CRP).
View Article and Find Full Text PDFArticle Synopsis
- Preterm birth is a major cause of perinatal death, and this study evaluates the effectiveness of antenatal care for women giving birth prematurely.
- The research involved a review of 161 women who delivered preterm and assessed their care quality, finding that only about 43% of high-risk and 50% of low-risk cases received 'good' care.
- Key issues identified included a lack of cervical length assessments and inadequate screening for bacterial vaginosis in high-risk patients, highlighting areas for potential improvement in care practices.
Microbe-binding Antibodies in the Female Genital Tract: Associations with the Vaginal Microbiome and Genital Immunology.
J Immunol
November 2024
Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- The study investigates how immune responses, specifically IgA and IgG antibodies, interact with bacteria in the female genital tract and their potential role in inflammation and bacterial colonization.
- Researchers analyzed cervicovaginal secretions from 200 HIV-uninfected women in Kenya and found that these antibodies frequently bind to specific vaginal bacteria, such as Gardnerella vaginalis and Lactobacillus species.
- Surprisingly, the presence of these microbe-binding antibodies was not linked to the abundance of the corresponding bacteria, suggesting they might help control inflammation rather than regulate immune responses like they do in the gut.
The In Vivo Effect of Water-Based Lubricants on the Vaginal Microbiome of Women from Varying Age Groups: Exploratory Analysis of a Randomized Controlled Trial.
Microorganisms
September 2024
Palacios Institute of Health and Women's Medicine, 28009 Madrid, Spain.
Article Synopsis
- Vaginal mucosa experiences physiological changes throughout a woman's life, including increased pH and decreased lubrication, which can lead to a higher risk of infections due to altered vaginal microbiome composition.
- This study aimed to evaluate the impact of water-based lubricants on the vaginal microbiome in women aged 18-65 who experience mild-to-moderate vaginal dryness, analyzing samples over different application time points.
- Results showed that while predominant bacteria like Lactobacilli were present, repeated use of lubricants did not significantly change the vaginal microbiome over four weeks; however, there were notable differences in microbiome diversity based on age and pH levels.
A Metagenomics Pipeline to Characterize Self-Collected Vaginal Microbiome Samples.
Diagnostics (Basel)
September 2024
Evvy, New York, NY 10016, USA.
Article Synopsis
- - Vaginitis is a common health issue affecting many women globally, with bacterial vaginosis (BV) being the most frequent type, found in 10-50% of reproductive-aged women.
- - Current diagnostic methods for BV are limited as they typically rely on clinical assessments or the detection of specific microbes, overlooking the complex changes in the vaginal microbiome.
- - A new shotgun metagenomic sequencing test has been developed, demonstrating high sensitivity and specificity for identifying various organisms in the vaginal microbiome, validated across over 7000 samples and certified by several health organizations.
Characterizing the vaginal microbiome in a sexually fluid primate (Pan paniscus).
Folia Primatol (Basel)
February 2024
Department of Anthropology, 12346University of Texas at San Antonio, San Antonio, TX 78249, USA.
Article Synopsis
- - Recent research has focused on the human vaginal microbiome, but studies on non-human primates (NHP), specifically bonobos, have been limited due to sample collection challenges.
- - This study aimed to characterize the bonobo vaginal microbiota for the first time and explore the relationship between vaginal pH and swelling size, collecting 71 vaginal swabs over 21 days.
- - The findings revealed a dominant presence of Actinobacteria and highlighted the lack of Lactobacillus spp., suggesting different factors may protect the bonobo vaginal environment; more extensive research is needed for deeper insights into how social and sexual factors affect vaginal microbiota.
Vaginal microbiota of pregnant women with and infections.
Front Cell Infect Microbiol
September 2024
Department of Obstetrics and Gynecology, School of Medicine, Eulji University, Daejeon, Republic of Korea.
Background: The association between preterm birth and species such as and has been extensively investigated. In a clinical setting, conventional diagnostic methods for them involve culture methods for spp. and spp.
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CMAJ
September 2024
Women's Health Center (Braunstein), Clalit Health Services, Tel Aviv, Israël; Département de gynécologie (Selk), Women's College Hospital, Toronto, Ont.; Département d'obstétrique et de gynécologie (Selk), University of Toronto, Toronto, Ont.
Article Synopsis
- - The study investigates bacterial vaginosis (BV) as a common cause of vaginal discharge and evaluates the effectiveness of two diagnostic methods: Amsel's criteria and Nugent's score.
- - Out of 135 samples analyzed, 44.4% had BV and 22.2% showed *Candida albicans* vaginitis, with Amsel's criteria displaying high sensitivity (94.7%) and specificity (92.3%) when compared to Nugent's score.
- - The findings suggest the importance of using Amsel's and Nugent's methods for diagnosing BV, highlight the link between recurrent BV and vulvovaginal candidiasis, and stress the need for further research on biofilms formed
Gardnerella vaginalis, Fannyhessea vaginae, and Prevotella bivia Strongly Influence Each Other's Transcriptome in Triple-Species Biofilms.
Microb Ecol
September 2024
Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), University of Minho, Braga, Portugal.
Bacterial vaginosis (BV), the most common vaginal infection worldwide, is characterized by the development of a polymicrobial biofilm on the vaginal epithelium. While Gardnerella spp. have been shown to have a prominent role in BV, little is known regarding how other species can influence BV development.
View Article and Find Full Text PDFPurified L-glutaminase effects against multidrug-resistant Pseudomonas aeruginosa in experimental vaginosis model: An immunological and histopathological observation.
Microb Pathog
November 2024
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia. Electronic address:
Article Synopsis
- A study examined the antimicrobial effects of L-glutaminase (an enzyme) from Lactobacillus gasseri against the drug-resistant bacteria Pseudomonas aeruginosa in a rat model of vaginosis.
- The treatment with L-glutaminase showed significant improvements in vaginitis symptoms, preserving healthy vaginal tissue structure and reducing inflammation compared to untreated animals.
- The findings suggest that L-glutaminase not only acts as an effective antimicrobial agent but also promotes healing, indicating potential for future clinical applications in treating bacterial vaginosis.
Synbiotics in patients at risk for spontaneous preterm birth: protocol for a multi-centre, double-blind, randomised placebo-controlled trial (PRIORI).
Trials
September 2024
Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Genk, Belgium.
Background: Prematurity remains one of the main causes of neonatal morbidity and mortality. Approximately two thirds of preterm births are spontaneous, i.e.
View Article and Find Full Text PDFAltered microbial diversity and composition of multiple mucosal organs in cervical cancer patients.
BMC Cancer
September 2024
Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), 519 Kunzhou Road, Xishan District, Kunming, 650118, China.
Article Synopsis
- The study aimed to analyze the microbiome across different mucosal organs (oral, gut, urinary tract, and vaginal) in patients with cervical cancer.
- Results indicated that cervical cancer patients showed lower diversity in their oral and gut microbiota, while their vaginal microbiota demonstrated higher diversity; significant differences in the composition of microbiota were found between cases and control groups.
- The research found specific bacterial groups enriched in the oral and urinary microbiota of cervical cancer patients, suggesting a connection between microbiome alterations and the presence of the disease.
Navigating the Microbial Landscape: Understanding Dysbiosis in Human Genital Tracts and Its Impact on Fertility.
Cureus
August 2024
Obstetrics and Gynaecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Dysbiosis, an imbalance in microbial communities in the genital tract, negatively affects fertility and reproductive health in both males and females.
- In females, a healthy vaginal microbiota dominated by Lactobacillus species is crucial for preventing infections and supporting reproductive functions, while in males, the genital microbiota influences sperm quality.
- The review discusses how dysbiosis can lead to reproductive issues like infertility and increased risk of infections, and it evaluates treatment options such as probiotics, antibiotics, and lifestyle changes aimed at restoring microbial balance and improving reproductive health.
Prevalence of bacterial vaginosis and its associated factors among pregnant women attending antenatal care clinics at public hospitals in West Shoa Zone, Oromia, Ethiopia.
Sci Rep
September 2024
Department of Midwifery, College of Health Sciences and Referral Hospital, Ambo University, Ambo, Ethiopia.
Article Synopsis
- Bacterial vaginosis (BV) is a common condition during pregnancy that occurs when healthy Lactobacilli decrease, leading to an overgrowth of other bacteria, and is linked to negative pregnancy outcomes like pre-term labor and low birth weight.
- A study in Ethiopia, involving 260 pregnant women from antenatal care clinics, found a BV prevalence of 22.3%, using the Nugent scoring system to analyze vaginal swab samples.
- Factors contributing to BV included living in rural areas, marital status, and hygiene practices; specific statistical methods (like logistic regression) were used to identify significant predictors of the condition.
Caribbean medicinal plant Argemone mexicana L.: Metabolomic analysis and in vitro effect on the vaginal microbiota.
J Ethnopharmacol
January 2025
Ph.D. Program in Biology, The Graduate Center, City University of New York, 365 5th Ave, New York, NY, 10016, USA; Department of Biological Sciences, Lehman College, City University of New York, 250 Bedford Park Blvd W, Bronx, NY, 10468, USA. Electronic address:
Ethnopharmacological Relevance: Medicinal plants are frequently used in Caribbean traditional medicine as low-cost, culturally relevant treatments for women's health concerns, such as gynecological infections. These plants are typically applied topically, potentially affecting both pathogenic bacteria (e.g.
View Article and Find Full Text PDFRelationship between dietary inflammatory index, plant-based dietary index, and bacterial vaginosis: A case-control study.
Int J Gynaecol Obstet
September 2024
Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Article Synopsis
- - The study investigates how different dietary factors are related to bacterial vaginosis (BV), a common vaginal condition, by comparing 143 individuals with BV to 151 healthy individuals aged 15-45.
- - Results show that a higher dietary inflammatory index (which indicates more inflammatory foods) significantly correlates with increased odds of having BV, even after adjusting for other factors.
- - Although there’s no strong link between overall plant-based diets and BV, an unhealthy plant-based diet is positively associated with higher BV odds, indicating some plant-based choices could be harmful.
Article Synopsis
- The study investigates whether oral probiotics, specifically Clostridium butyricum, can reduce the rate of recurrent spontaneous preterm delivery (sPTD) among pregnant women with a history of sPTD, with a focus on understanding their potential role in pregnancy maintenance.
- This is a multicenter, nonblinded clinical trial set in Japan, aiming to enroll 345 participants to evaluate various outcomes related to sPTD over a period expected to conclude in March 2025.
- Results from this research will provide insights into the effectiveness of probiotics and potentially influence clinical guidelines and future studies on managing preterm deliveries.
Insights into the assembly of the neovaginal microbiota in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome patients.
Nat Commun
September 2024
National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, State Key Laboratory for Complex Severe and Rare Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, 100005, Beijing, China.
Article Synopsis
- - Neovaginas can be surgically created for women with MRKH syndrome or during gender-affirming surgery, and studying their microbiota is essential for effective management.
- - A longitudinal study showed that the neovaginal microbiota initially had random characteristics with an increase in Enterococcus faecalis and Mycoplasmas, but evolved to resemble a normal vagina within 6-12 months after surgery.
- - By 2-4 years post-surgery, the neovaginal microbiota aligned more closely with pre-surgery microbiota, particularly with the presence of Lactobacillus crispatus, indicating its association with vaginal health and opportunities for enhancing its colonization.
Sexually transmitted infections and bacterial vaginosis among adolescent girls and young women in the early postpartum period: a cross-sectional study.
BMC Infect Dis
September 2024
Department of Obstetrics and Gynaecology, School of Clinical Medicine, University of KwaZulu Natal, Durban, South Africa.
Article Synopsis
- Universal antiretroviral treatment (ART) has decreased the risk of mother-to-child HIV transmission, but many women on ART are not fully virally suppressed during and after pregnancy due to factors like poor treatment adherence and co-infections.* -
- This study analyzed the prevalence of sexually transmitted infections (STIs) among adolescent girls and young women both living with HIV and without HIV during their postpartum clinic visits in South Africa.* -
- Results showed that 21.7% of women tested positive for STIs postpartum, with higher rates found in women living with HIV, and significant proportions also had bacterial vaginosis, which can complicate their health outcomes.*
Lipopolysaccharide Triggers Luminal Acidification to Promote Defense Against Bacterial Infection in Vaginal Epithelium.
Am J Pathol
December 2024
School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:
The vaginal epithelium plays pivotal roles in host defense against pathogen invasion, contributing to the maintenance of an acidic microenvironment within the vaginal lumen through the activity of acid-base transport proteins. However, the precise defense mechanisms of the vaginal epithelium after a bacterial infection remain incompletely understood. This study showed that bacterial lipopolysaccharide (LPS) potentiated net proton efflux by up-regulating the expression of Na-H exchanger 1 (NHE1) in vaginal epithelial cells.
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