7,243 results match your criteria: "Gardnerella"
Effects of LM1215 on and .
Yonsei Med J
December 2024
Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Purpose: The aim of this study was to identify novel vaginal probiotics with the potential to prevent vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV).
Materials And Methods: Eighteen strains of were isolated from healthy Korean women, and their antimicrobial effects against and were assessed. Three strains ( LM1203, LM1209, and LM1215) were selected for further investigation, focusing on their growth inhibition, biofilm regulation, and cellular mechanisms against these vaginal pathogens.
Differential study on the relationship between HPV infection and vaginal microbiota composition in Uygur and Han women.
Microb Pathog
January 2025
Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China; Xinjiang Cervical Cancer Prevention and Treatment Clinical Research Center, China. Electronic address:
Article Synopsis
- The study aimed to analyze how HPV infections affect vaginal microbial communities in Uygur and Han women, examining the correlation between these differences and the severity of HPV infection.
- Researchers analyzed vaginal microbiota of 151 women (both Uygur and Han) using 16S rDNA sequencing, categorizing them into groups based on HPV infection status.
- Results indicated that HPV infection altered vaginal pH and microbial diversity, with notable differences in dominant bacteria and community structure between Uygur and Han women, suggesting distinct ethnic variations in response to HPV.
Article Synopsis
- The vaginal microbiota plays a significant role in the health of women and newborns, but its ecological dynamics and stability are not fully understood.
- This study investigates how nutritional resources, particularly glycogen and sialic acid, influence the composition of vaginal bacterial communities, highlighting the connection between resource availability and bacterial behavior.
- Using a new mathematical model, the research finds that bacteria associated with bacterial vaginosis (BV) thrive due to their exclusive access to certain nutrients, which helps them resist changes in their community structure, providing insights for potential BV prevention strategies.
Analysis of vaginal microbiota during postpartum and postmenopausal periods based on metagenomics.
BMC Microbiol
November 2024
Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, 100026, China.
Article Synopsis
Mechanisms of S. agalactiae promoting G. vaginalis biofilm formation leading to recurrence of BV.
NPJ Biofilms Microbiomes
November 2024
Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Article Synopsis
Molecular Exploration of and in Mexican Women with Cervicitis.
Pathogens
November 2024
Molecular and Cellular Bioimmunology Laboratory, National Institute of Perinatology, Montes Urales 800, Col Lomas Virreyes, Mexico City 11000, Mexico.
Article Synopsis
- Genital Mycoplasmas are linked to negative pregnancy outcomes and infertility, but more research is needed to understand their exact role.
- The study analyzed 228 endocervical samples from pregnant and non-pregnant women using end-point PCR to detect various Mycoplasma species.
- The findings showed that certain Mycoplasma species were associated with bacterial vaginosis, indicating a potential contribution to its development, though no clear link was found to infertility or adverse pregnancy outcomes.
Development and Characterization of Sodium Bicarbonate-Based Gel for Cytolytic Vaginosis.
Pharmaceutics
November 2024
CICS-UBI-Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-358 Covilhã, Portugal.
Cytolytic vaginosis or, classically, Doderlein's cytolysis is characterized by significant growth of species of the genus, which leads to high amounts of lactic acid in the vaginal environment. has been proposed as a key pathogen in this clinical condition. The symptomatology of cytolytic vaginosis is commonly confused with that of vulvovaginal candidosis, leading to inadequate and ineffective azole therapies.
View Article and Find Full Text PDFCeragenins Prevent the Development of Murine Vaginal Infection Caused by .
Pharmaceuticals (Basel)
October 2024
Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Białystok, 15-222 Białystok, Poland.
Article Synopsis
Cell-Free Supernatant of Vaginal Viridans Streptococcus Induces Membrane Permeabilization and Transcriptional Regulation in Methicillin-Resistant Staphylococcus aureus.
Probiotics Antimicrob Proteins
November 2024
Department of Immunology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-Ro, Jung-Gu, Daegu, 41944, Republic of Korea.
Article Synopsis
- The genus Streptococcus includes both harmless and harmful bacteria that naturally reside in the human body, particularly in the female genital tract (FGT), where there are two main groups: the pathogenic group B Streptococci (GBS) and the commensal viridans group streptococci (VGS).
- A novel strain named Streptococcus sp. K0074 was isolated from a vaginal swab of an endometrial cancer patient and showed potential as a commensal member of the VGS, specifically within the mitis subgroup.
- This strain produced a bacteriocin-like substance that can inhibit the growth and biofilm formation of the harmful bacterium MRSA, suggesting it may play a significant
Complications in Pelvic Organ Prolapse With 3-Month Versus 6-Month Pessary Care: Pilot Study.
Urogynecology (Phila)
November 2024
From the Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Article Synopsis
- The study investigates the safety and complications of vaginal pessary use for women with pelvic organ prolapse (POP) by comparing follow-up intervals of 3 months versus 6 months.
- In this randomized clinical trial, 38 women with advanced POP were divided into two groups to assess the impact of differing cleaning and monitoring frequencies by a healthcare professional.
- Results showed no significant difference in ulcerations between the groups, but the 6-month group had a higher incidence of bacterial vaginosis, suggesting more frequent follow-up may be beneficial.
Preoperative vaginal microbiome as a predictor of postoperative urinary tract infection.
Sci Rep
November 2024
Department of Surgery, Department of Obstetrics and Gynecology, Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- This study involved 22 postmenopausal women with pelvic organ prolapse set to undergo vaginal hysterectomy and pelvic reconstructive surgery, and it focused on the relationship between their vaginal microbiome and postoperative urinary tract infections (UTIs).
- Researchers collected vaginal and urine samples at five different times during the surgical process to analyze the microbiome, particularly looking for changes in bacteria types through DNA sequencing.
- The results showed that women who developed UTIs post-surgery had a unique vaginal microbiome profile, featuring low levels of Lactobacillus and higher levels of Prevotella and Gardnerella, suggesting that preoperative microbiome analysis can help predict UTI risk after the surgery.
Effect of metronidazole on concentrations of vaginal bacteria associated with risk of HIV acquisition.
mBio
December 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Article Synopsis
- A study examined the effects of metronidazole, an antibiotic, on bacterial vaginosis (BV)-associated bacteria, which are linked to a higher risk of acquiring HIV.
- Vaginal samples from 22 individuals were taken daily after a BV diagnosis, revealing that metronidazole significantly reduced the concentration of various bacteria over a treatment period of 5-7 days.
- The results indicated that, while most bacterial levels decreased substantially, some bacteria took longer to be cleared, suggesting that metronidazole could be an effective method to reduce potential HIV infection risk linked to these bacteria.
Previse preterm birth in early pregnancy through vaginal microbiome signatures using metagenomics and dipstick assays.
iScience
November 2024
Functional Genomics Laboratory, Centre for Microbial Research, BRIC-Translational Health Science and Technology Institute (BRIC-THSTI), NCR Biotech Science Cluster, Faridabad, India.
Article Synopsis
- In India, 13% of newborns are preterm, contributing to a significant portion (23.4%) of global preterm births.
- A study was conducted analyzing 600 high vaginal swab samples from pregnant women across all trimesters to compare microbiome differences between those who delivered at term and those with preterm births.
- The research identified specific microbial signatures linked to term and preterm births and developed a simple dipstick assay for quick identification of preterm-associated bacteria in low-resource settings.
Suggested Screening Criteria for Gardnerella vaginalis Based on Established Risk Factors.
Cureus
October 2024
Rheumatology, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, USA.
Article Synopsis
- Vaginal infections, particularly bacterial vaginosis (BV), arise from a decrease in beneficial lactobacilli and an increase in harmful bacteria, with various risk factors identified including smoking, ethnicity, and socioeconomic status.
- A scoping review analyzed 438 articles and included 31, finding that sexually active women engaging in unprotected or frequent vaginal sexual activities had higher instances of BV, with education level and socioeconomic status also influencing risk.
- The study suggests the need for an updated screening tool for clinicians to assess a patient's risk of BV, particularly in high-risk groups like pregnant or immunocompromised women.
[Postcoital cystitis in menopause].
Urologiia
July 2024
FGBOU VO Novosibirsk State Medical University of Ministry of Health of Russia, Novosibirsk, Russia.
Article Synopsis
- Postcoital cystitis, a condition causing painful urination linked to sexual activity, negatively impacts patients' emotional wellbeing and overall quality of life, with reduced interest in surgical interventions due to better antibacterial treatments and hygiene practices.
- A study involving 56 menopausal women examined the efficacy of Superlymph suppositories, assessing their impact on postcoital cystitis symptoms through questionnaires and urine tests, while maintaining normal sexual activity.
- Results indicated that the first cystitis episode typically occurred around age 33, with a significant portion of women experiencing symptoms related to sexual activity, highlighting the need for effective management strategies in this population.
Performance of deep learning models in predicting the nugent score to diagnose bacterial vaginosis.
Microbiol Spectr
November 2024
Department of Clinical Laboratory, Kameda Medical Center, Kamogawa, Chiba, Japan.
Article Synopsis
- The study evaluates the use of deep learning models to predict the Nugent score, a diagnostic tool for bacterial vaginosis, improving accuracy and consistency in diagnostics.
- Researchers analyzed 1,510 vaginal smear images and developed deep learning models, achieving an accuracy of 94% after optimization, which surpassed the average accuracy of laboratory technicians.
- Findings highlight that deep learning can effectively diagnose bacterial vaginosis, potentially addressing challenges in areas with limited access to skilled technicians.
Clinical laboratory evaluation of the Hologic Panther Aptima BV and CV/TV assays for the diagnosis of vaginitis in Dunedin, Aotearoa New Zealand.
Microbiol Spectr
November 2024
Department of Microbiology, Awanui Labs Dunedin, Dunedin Hospital, Dunedin, New Zealand.
Vaginitis presentations are common, but traditional diagnostic methods are imperfect. Molecular methods for bacterial vaginosis (BV) and vulvovaginal candidiasis (CV) are increasingly available but not commonly utilized in Aotearoa New Zealand. We evaluated the Hologic Aptima BV and CV/ (TV) assays against our current methods (Gram stain, yeast culture, and Hologic Aptima TV assay) and performed a retrospective BV clinical audit.
View Article and Find Full Text PDFHistory of cervical excisional treatment is associated with changes in the cervical microbiota in women with preterm prelabor rupture of membranes.
J Matern Fetal Neonatal Med
December 2024
Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Article Synopsis
- The study investigated how cervical load and bacterial DNA prevalence differ in pregnant women with preterm prelabor rupture of membranes (PPROM), particularly focusing on those with and without a history of cervical excisional treatment.
- Women who had cervical excisional treatment showed higher cervical loads of specific bacterial DNA compared to those without such a history.
- Additionally, the length of the excisional cone influenced the bacterial DNA levels, suggesting that longer cone lengths were associated with distinct microbiota changes.*
'From women for women': A citizen science approach engaging women in the isolation and application of the vaginal health-associated bacterium Lactobacillus crispatus.
PLoS One
November 2024
Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- * A citizen science initiative engaged women to collect vaginal swabs and isolate their own Lactobacillus crispatus strains, demonstrating that non-experts can successfully contribute to scientific research.
- * The project fostered community involvement and aimed to develop a woman-friendly probiotic product, suggesting a proactive approach to enhancing vaginal health and exploring new research avenues.
Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation.
mBio
December 2024
Department of Obstetrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Article Synopsis
- Preterm birth (PTB) significantly contributes to perinatal mortality and morbidity, and the cervicovaginal microbiome's abnormality during pregnancy is linked to increased PTB risk.
- Research involving 103 pregnancy samples indicates microbiome dysbiosis, particularly a drop in lactobacilli and rise in anaerobes, correlates with PTB, alongside higher acetic acid levels found in preterm births.
- The study identifies a potential diagnostic marker set combining pregnancy type, acetic acid concentration, and microbial community state, suggesting that cervicovaginal microbiota plays a crucial role in PTB's etiology by influencing inflammatory responses and trophoblast cell behavior.
Is there any difference in Lactobacillus abundance between age groups during ovarian stimulation in fresh in vitro fertilization (IVF) cycles?
Med Glas (Zenica)
September 2024
Institute for Human Reproduction "Dr. Balić", Tuzla, Bosnia and Herzegovina.
Aim: To investigate an influence of age and body mass index (BMI) as determinants of infertility treatment success in vitro fertilization (IVF) procedures confirmed so far, on the amount of Lactobacilus spp. (LS) and Gardnerella vaginalis (GV) in the endometrium in fresh IVF cycles at the time of embryo transfer.
Methods: This a prospective single-centre study included patients who underwent fresh embryo transfer (ET) in a private IVF Centre.
Menstrual cups to reduce bacterial vaginosis and STIs through reduced harmful sexual and menstrual practices among economically vulnerable women: protocol of a single arm trial in western Kenya.
BMC Public Health
November 2024
Division of Infectious Disease Medicine, Rush University College of Medicine, Chicago, USA.
Background: In western Kenya, menstrual hygiene management (MHM) is a pervasive problem. Challenges are compounded for economically constrained women who continue to engage in sex during menses and resort to practices such as vaginal insertion of tissue and cotton to maintain dryness during sex. These practices can be harmful to the vaginal microbiome (VMB) and can lead to high rates of sexually transmitted infections (STIs) and HIV.
View Article and Find Full Text PDFUnraveling the impact of host genetics and factors on the urinary microbiome in a young population.
mBio
December 2024
BGI Research, Wuhan, China.
Article Synopsis
- The study examines the urinary microbiome's role in health and disease by analyzing a large cohort of 1,579 Chinese individuals using advanced sequencing techniques.
- Researchers identified five unique microbial profiles, known as "urotypes," and found that gender and sex hormones significantly influence these microbiomes.
- Additionally, the study revealed 43 genetic associations linked to specific urinary bacteria, underscoring the complex relationship between host genetics and microbiome composition.
The relationship between the vaginal and vulvar microbiomes and lichen sclerosus symptoms in post-menopausal women.
Sci Rep
November 2024
Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Lichen sclerosus is a chronic inflammatory condition of unknown etiology that affects the genital and extragenital skin, which can lead to sexual dysfunction and has been associated with vulvar cancer. The vaginal microbiome has a critical role in gynecologic health, but little is known about the microbiome in lichen sclerosus. This study investigated the vaginal and vulvar microbiomes of 27 post-menopausal women with lichen sclerosus.
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