7,243 results match your criteria: "Gardnerella"

Background: The application of '-omics' technologies to study bacterial vaginosis (BV) has uncovered vast differences in composition and scale between the vaginal microbiomes of healthy and BV patients. Compared to amplicon sequencing and shotgun metagenomic approaches focusing on a single or few species, investigating the transcriptome of the vaginal microbiome at a system-wide level can provide insight into the functions which are actively expressed and differential between states of health and disease.

Results: We conducted a meta-analysis of vaginal metatranscriptomes from three studies, split into exploratory (n = 42) and validation (n = 297) datasets, accounting for the compositional nature of sequencing data and differences in scale between healthy and BV microbiomes.

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Two separate online surveys were presented to women who were confirmed to have purchased a boric acid vaginal suppository product in the previous year for themselves March 2020 (study 1) and July 2023 (study 2) to understand consumer expectations concerning the use of vaginal boric acid. Study 1 found that repeat purchasers are more likely to buy boric acid products to prevent symptoms, especially bacterial vaginosis. Study 2 confirmed boric acid was more likely to be purchased for prevention than treatment, especially odor/bacterial vaginosis, with 83% reporting they were satisfied and 40% reporting they were extremely satisfied.

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The role of reproductive tract microbiota in gynecological health and diseases.

J Reprod Immunol

December 2024

Department of gynaecology and obstetrics, Gynecological Diagnosis and Treatment Center, Affliated Hospital of Changchun University of Chinese Medicine, No.2, Shenzhen Street, Changchun city, Jilin Province 130000, China. Electronic address:

The reproductive tract, as a lumen connected to the outside world, its microbial community is influenced by various factors. The changes in its microbiome are closely related to women's health. The destruction of the micro ecological environment will lead to various infections, such as Bacterial vaginosis, sexually transmitted infections, adverse pregnancy outcomes, infertility and tumors.

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Background: Less than one-third of sub-Saharan Africans have access to improved water sources. In US, Indian, and African studies, Bacterial vaginosis (BV) is increased among women with poor water, sanitation, and hygiene (WASH). We examined water source, sanitation (latrine type), and rainfall in relation to the vaginal microbiome (VMB).

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Background: A significant proportion of individuals with symptoms of sexually transmitted infection (STI) delay or avoid seeking healthcare, and digital diagnostic tools may prompt them to seek healthcare earlier. Unfortunately, none of the currently available tools fully mimic clinical assessment or cover a wide range of STIs.

Methods: We prospectively invited attendees presenting with STI-related symptoms at Melbourne Sexual Health Centre to answer gender-specific questionnaires covering the symptoms of 12 common STIs using a computer-assisted self-interviewing system between 2015 and 2018.

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Assessment of the vaginal microbiota before and after use of hyperosmolal lubricant during transvaginal ultrasound.

Am J Obstet Gynecol

December 2024

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Background: Vaginal lubricants are commonly used during sexual activity and clinical procedures such as transvaginal ultrasound (TVUS). Epidemiologic and laboratory studies indicate hyperosmolal water-based lubricants may disrupt the vaginal microbiota, particularly the beneficial Lactobacillus spp. These bacteria play a critical role in protecting against sexually transmitted infection acquisition and other adverse gynecologic and obstetric outcomes.

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Exploration and application of microorganisms related to the inference of the time since deposition (TsD) in semen and blood stains.

Int J Legal Med

December 2024

Department of Forensic Science, School of Basic Medical Sciences, Central South University, No. 172 Tongzipo Road, Changsha, Hunan Province, 410013, PR China.

Determining the time since deposition (TsD) of body fluid stains can provide crucial criminal information to forensic researchers. Although there are studies on inferring residual time through DNA and RNA markers, this requires high sample quality, and microorganisms, as a new type of marker with individual and tissue identification capabilities, have the potential for body fluid recognition and TsD inference. Blood and semen are the most common types of bodily fluid stains at crime scenes, but research on the inference of the TsD of these two types of stains through microorganisms still needs to be explored.

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Cervicovaginal (CV) microbiota is critical for the well-being of host. We investigated the relationship between the ratio of (LB) and (C/CB)-type microbial cells with biofilm formation of CV mixed cultures of women with no inflammation/infection or any epithelial abnormalities in Pap-stained smears Group 1 (G1) corresponds to the flora with LB-type cells alone, whereas G2 corresponds to the LB-dominated flora. G3 contains balanced LB and C/CB cells and G4 is dominated with C/CB.

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The Human Microbiome Project (HMP), initiated in 2007, aimed to gather comprehensive knowledge to create a genetic and metabolic map of human-associated microorganisms and their contribution to physiological states and predisposition to certain diseases. Research has revealed that the human microbiome is highly diverse and exhibits significant interpersonal variability; consequently, its exact impact on health remains unclear. With the development of next-generation sequencing (NGS) technologies, the broad spectrum of microbial communities has been better characterized.

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Previous studies have linked the microbiome of distinct body habitats to obesity and infertility; however, the often-divergent results observed have left the role of the so-called "second genome" in obese infertile patients incompletely explored. Here, we present a prospective observational multicenter study of oral, gut, endometrial, and vaginal microbiota of infertile patients classified according to BMI. Patients collected saliva/fecal samples, while vaginal/endometrial fluid samples were collected in the clinic.

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Unlabelled: Premature rupture of membranes (PROM) and cervical incompetence (CI) are major contributors to preterm birth, a leading cause of neonatal morbidity and mortality.

Background/objectives: Disorders of the vaginal microbiota, such as bacterial vaginosis, have been associated with an increased risk of PROM, CI, and subsequent preterm birth. Probiotics, particularly Lactobacillus strains, have been proposed as a preventive strategy to restore and maintain a healthy vaginal microbiome.

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Differential characteristics of vaginal versus endometrial microbiota in IVF patients.

Sci Rep

December 2024

Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitätsklinikum Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany.

Abnormal female reproductive tract microbiota are associated with gynecological disorders such as endometriosis or chronic endometritis and may affect reproductive outcomes. However, the differential diagnostic utility of the vaginal or the endometrial microbiome and the impact of important technical covariates such as the choice of hypervariable regions for 16 S rRNA sequencing remain to be characterized. The aim of this retrospective study was to compare vaginal and endometrial microbiomes in IVF patients diagnosed with implantation failure (IF) and/or recurrent pregnancy loss (RPL) and to investigate the overlap between established vaginal and endometrial microbiome classification schemes.

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Chronic endometritis and fertility: A binomial linked by microorganisms.

Eur J Obstet Gynecol Reprod Biol

November 2024

Department of Microbiology, School of Medicine, University of Granada-ibs, 18014 Granada, Spain; Department of Microbiology, Hospital Universitario Virgen de las Nieves-ibs, 18014 Granada, Spain.

Objectives: To explore the relationship of microorganisms with chronic endometritis, comparing findings in our region with reports in the literature.

Study Design: Retrospective descriptive study of 110 endometrial biopsies from women treated for fertility problems at a tertiary hospital from 2021 through 2022. Results were compared between women with and without chronic endometritis.

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Purpose Of Review: Women in Africa bear the burden of the HIV epidemic, which has been associated with the high prevalence of bacterial vaginosis (BV) in the region. However, little progress has been made in finding an effective cure for BV. Drawing on advances in microbiome-directed therapies for gastrointestinal disorders, similar live-biotherapeutic based approaches for BV treatment are being evaluated.

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Article Synopsis
  • Depletion of species in the vaginal tract leads to bacterial vaginosis (BV), which is linked to poor reproductive health and higher risk of STIs; current antibiotic treatments have low success rates.
  • A study conducted in Cape Town explored blood donors' knowledge and attitudes toward vaginal microbiota transplantation (VMT) as a potential alternative treatment for BV through a questionnaire.
  • Results showed a significant majority (86%) of women were open to donating vaginal samples, with willingness increased by a belief in helping others and prior knowledge of healthy vaginal microbiomes; concerns about discomfort and embarrassment affected those unwilling to donate.
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Unlabelled: Bacterial vaginosis (BV) is an abnormal gynecological condition caused by the overgrowth of specific bacteria in the vagina. This study aims to develop a novel method for BV detection by integrating surface-enhanced Raman scattering (SERS) with machine learning (ML) algorithms. Vaginal fluid samples were classified as BV positive or BV negative using the BVBlue Test and clinical microscopy, followed by SERS spectral acquisition to construct the data set.

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Microbial infection is a significant health issue for humans. Despite the development of numerous antibiotics, the continuous rise of drug-resistant bacteria highlights the urgent need for new materials to combat these problems. In this study, four water-soluble quaternized cellulose (QC) derivatives with degrees of substitution (DS) ranging from 0.

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Background: Systematic study on the relationship between vaginal microbiota and high-risk human papillomavirus infection (HR-HPV) is limited. Hence, the aim of this study is to investigate the correlation between vaginal microbiota and HR-HPV infection through a meta-analysis of case-control studies.

Methods: Chinese Journal Full-text database, Wanfang database, PubMed database, VIP Chinese Science and Technology Journal database, Web of Science, ScienceDirect, ProQuest, JSTOR, Wiley, and IEEE Xplore were synthetically searched for studies about the correlation between vaginal microbiota and HR-HPV infection.

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Article Synopsis
  • In sub-Saharan Africa, girls aged 15-19 represent 86% of HIV infections, underscoring the need to understand risk factors affecting them compared to adult women in South Africa.
  • A study of 305 adolescent girls and 114 adult women in two South African provinces revealed that while adults reported higher risk sexual behaviors, adolescents had a higher prevalence of STIs (62.8% vs 34.0% in the Western Cape).
  • Factors like earlier sexual debut and the use of intravaginal sexual enhancers among adolescents were significant, and behavioral risk factors such as the number of sexual partners and recent sexual activity were linked to STI presence in both age groups.
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Introduction: Menstruation is a normal physiological event that takes place in a rhythmic fashion during the reproductive period of a woman. Menstrual hygiene management (MHM) practices differ and depend on the individual's socioeconomic status, local traditions and beliefs, and access to water and sanitation resources. Insufficient and incorrect information regarding menstruation and lack of knowledge and awareness leads to poor personal hygienic practices, which further leads to many infections.

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Influence of vitamin D supplementation and the vaginal microenvironment on human papillomavirus infection.

Afr J Reprod Health

October 2024

Department of Gynecology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.

Article Synopsis
  • The study investigated how the vaginal microenvironment affects HPV infection and the role of vitamin D in this context, using data from 512 participants categorized into HPV positive and negative groups.
  • It was found that the high-risk HPV (HR-HPV) group had higher abnormal rates of certain microbial and biochemical markers compared to the HPV negative group, indicating a link between these factors and HPV infection.
  • Vitamin D supplementation showed promise in reducing the persistence of HR-HPV after treatment, while also improving overall nutritional and metabolic health by lowering inflammation and other risk factors.
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Article Synopsis
  • This study focused on identifying immune states that increase the risk of preterm birth by examining the immune characteristics and microbial profiles of pregnant women.
  • Researchers used advanced methods like immunophenotyping, microbial sequencing, and statistical analysis to differentiate between immune subtypes and their relationship with preterm birth.
  • The findings revealed three immune subtypes, notable differences in vaginal microbiota, and specific immune factors linked to preterm birth, suggesting intricate interactions between immune responses and microbial composition.
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