5 results match your criteria: "Gansu Urological Clinical Center[Affiliation]"
A machine learning-based prognostic signature utilizing MSC proteomics for predicting bladder cancer prognosis and treatment response.
Transl Oncol
March 2025
Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Gansu Urological Clinical Center, Lanzhou, China. Electronic address:
Background: Mesenchymal stem cells (MSCs), due to their tumor-targeting homing properties, are present in the tumor microenvironment (TME) and influence the biological behaviors of tumors. The purpose of this paper is to establish a signature based on the MSC secretome to predict the prognosis and treatment of bladder cancer (BLCA).
Methods: The presence of MSCs in BLCA was validated through flow cytometry and multiplex fluorescence immunohistochemistry (mFIHC), and the relationships between MSCs and clinical characteristics were explored.
Identification of a Novel Mesenchymal Stem Cell-Related Signature for Predicting the Prognosis and Therapeutic Responses of Bladder Cancer.
Stem Cells Int
November 2024
Institute of Urology, Key Laboratory of Gansu Province for Urological Diseases, Gansu Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Article Synopsis
- Mesenchymal stem cells (MSCs) show a specific tendency to move towards tumors, impacting cancer growth, treatment resistance, and immune response, prompting research into MSC-related biomarkers for better predicting bladder cancer outcomes.
- This study used data from TCGA and GSE31684 to identify genes linked to MSCs and created a risk assessment model through advanced statistical analysis techniques.
- The final prognostic model highlighted five key genes and classified bladder cancer patients into risk categories, revealing that high MSC-risk patients faced worse outcomes and lower responsiveness to immunotherapy and specific chemotherapy drugs compared to low MSC-risk patients.
Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.
Cell Death Dis
September 2024
Institute of Urology, Lanzhou University Second Hospital; Key Laboratory of Gansu Province for Urological Diseases; Gansu Urological Clinical Center, Lanzhou, China.
Mesenchymal stem cells (MSCs) in tumor microenvironment (TME) are crucial for the initiation, development, and metastasis of cancer. The impact and mechanism of MSCs on bladder cancer are uncertain. Here we analyzed 205 patient samples to explore the relationships between tumor-stroma ratio and clinicopathological features.
View Article and Find Full Text PDFMELATONIN ATTENUATES RENAL ISCHEMIA-REPERFUSION INJURY BY REGULATING MITOCHONDRIAL DYNAMICS AND AUTOPHAGY THROUGH AMPK/DRP1.
Shock
July 2024
Department of Urology, Institute of Urology, Gansu Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou, China.
Ischemia-reperfusion injury (IRI) often stems from an imbalance between mitochondrial dynamics and autophagy. Melatonin mitigates IRI by regulating mitochondrial dynamics. However, the precise molecular mechanism underlying the role of melatonin in reducing IRI through modulating mitochondrial dynamics remains elusive.
View Article and Find Full Text PDFProteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury.
J Transl Med
March 2024
Department of Urology, Institute of Urology, Gansu Urological Clinical Center, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China.
Background: The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (MAMs). Many important cellular functions such as bioenergetics, mitophagy, apoptosis, and calcium signaling are regulated by MAMs, which are thought to be closely related to ischemic reperfusion injury (IRI). However, there exists a gap in systematic proteomic research addressing the relationship between these cellular processes.
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