9 results match your criteria: "Gansu Provincial Maternity and Childcare Hospital[Affiliation]"
Maternal and fetal risk factors for congenital anomalies of the kidney and urinary tract: a birth cohort study in urban China.
J Nephrol
December 2024
Department of Nephrology, Gansu Provincial Clinical Medical Research Center for Renal Diseases, The Second Hospital and Clinical Medical School, Lan Zhou University, No. 82, Cui Yingmen, Linxia Road, Chengguan District, Lanzhou, Gansu Province, China.
Article Synopsis
- Congenital anomalies of the kidney and urinary tract (CAKUT) are common causes of kidney diseases in children, often linked to genetic factors, but this study focuses on identifying modifiable maternal and fetal risks classified by disease phenotype.
- A cohort study involved over 10,000 women who delivered in Lanzhou, China, collecting data through interviews and medical records to assess the link between maternal conditions and CAKUT in newborns.
- Analysis found that maternal overweight, gestational diabetes, preterm birth, and low birth weight were independent risk factors for CAKUT, with specific risks for different CAKUT phenotypes like vesicoureteral reflux and ureteropelvic junction obstruction.
Metal stannum exposure increases the risk of congenital heart defects occurence in offspring: A case-control study in Lanzhou.
Int J Cardiol
September 2024
The first Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; Gansu Provincial Maternity and ChildCare Hospital, Lanzhou 730000, Gansu Province, China. Electronic address:
Article Synopsis
- The study aimed to investigate the link between stannum exposure during pregnancy and the occurrence of congenital heart diseases (CHDs) in children.
- It followed 14,359 pregnant women over two years, comparing 97 women whose babies were diagnosed with CHDs to 194 without, analyzing blood samples for stannum levels.
- Results indicated that higher levels of stannum in mothers' blood were significantly associated with an increased risk of various types of CHDs, suggesting that stannum can cross the placenta to affect fetal development.
Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson's disease.
Chin Neurosurg J
April 2023
Intensive Care Center of Gynecology and Obstetrics, Gansu Provincial Maternity and Childcare Hospital, Lanzhou, 730050, Gansu, China.
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathologic characteristic feature is the loss of dopaminergic neurons in the substantia nigra (SN). However, the biochemical mechanisms are unclear.
View Article and Find Full Text PDFPrenatal diagnosis of congenital left ventricular diverticulum.
Ultrasound Obstet Gynecol
June 2023
Ultrasound Medicine Center, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China.
Suppression Of Aberrant Activation Of NF-κB Pathway In Drug-resistant Leukemia Stem Cells Contributes To Parthenolide-potentiated Reversal Of Drug Resistance In Leukemia.
J Cancer
July 2021
School of Basic Medical Sciences, Lanzhou University; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, 99 Dong Gang West Road, Lanzhou, 730000 Gansu, China.
Although many drugs that targeted the specific features of leukemia stem cells (LSCs) have substantial application in the clinical treatment of leukemia, the LSCs relapsed and caused drug-resistant leukemia. Therefore, it is necessary to identify the unique features of LSCs in relapsing and drug-resistant leukemia and also to explore the drugs that directed at these features. Our clinical data have indicated that relapsed patients with acute myeloid leukemia have more abundant proportion of LSCs with enhanced breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) expression when compared to the untreated patients.
View Article and Find Full Text PDFComparative investigation of early-onset gastric cancer.
Oncol Lett
May 2021
The Second Clinical Medical College, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu 730030, P.R. China.
Early-onset gastric cancer (EOGC) is a serious social burden. For patients with EOGC, typically considered as those aged <45 years, the underlying cause of the disease remains unclear. In addition, several misunderstandings of EOGC remain in clinical practice.
View Article and Find Full Text PDFA SNP involved in alternative splicing of is associated with clopidogrel resistance in coronary heart disease in Chinese population.
Aging (Albany NY)
November 2020
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
Although many scientists are studying the association between genetic polymorphism of and CR in patients, the molecular mechanism has not been further studied in patients with CHD. This study investigated the relationship between SNP of the gene in patients with CHD and CR, and whether the polymorphism of the gene affects the AS of the gene. 741 patients were enrolled in the study, 316 CR cases and 425 NCR cases.
View Article and Find Full Text PDFFamily Integrated Care for Preterm Infants in China: A Cluster Randomized Controlled Trial.
J Pediatr
January 2021
Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.
Objective: To explore whether family integrated care (FICare) is feasible and improves the outcomes of preterm infants in China.
Study Design: This was a multicenter prospective cluster-randomized controlled trial comparing FICare and standard care. The primary outcome was length of stay (LOS).
The Association Between Maternal Subclinical Hypothyroidism and Growth, Development, and Childhood Intelligence: A Meta-analysis.
J Clin Res Pediatr Endocrinol
June 2018
Gansu Provincial Maternity and Childcare Hospital, Lanzhou, Gansu, China
Objective: To explore the association between maternal subclinical hypothyroidism (SCH) in pregnancy and the somatic and intellectual development of their offspring.
Methods: Using RevMan 5.3 software, a meta-analysis of cohort studies published from inception to May 2017, focusing on the association between maternal SCH in pregnancy and childhood growth, development and intelligence, was performed.