Peopling History of the Tibetan Plateau and Multiple Waves of Admixture of Tibetans Inferred From Both Ancient and Modern Genome-Wide Data.

Archeologically attested human occupation on the Tibetan Plateau (TP) can be traced back to 160 thousand years ago (kya) via the archaic Xiahe people and 30∼40 kya via the Nwya Devu anatomically modern human. However, the history of the Tibetan populations and their migration inferred from the ancient and modern DNA remains unclear. Here, we performed the first ancient and modern genomic meta-analysis among 3,017 Paleolithic to present-day Eastern Eurasian genomes (2,444 modern individuals from 183 populations and 573 ancient individuals).

Y-chromosome evidence confirmed the Kerei-Abakh origin of Aksay Kazakhs.

Aksay Kazakhs are the easternmost branch of Kazakhs, residing in Jiuquan city, the forefront of the ancient Silk Road. However, the genetic diversity of Aksay Kazakhs and its relationships with other Kazakhs still lack attention. To clarify this issue, we analyzed the non-recombining portion of the Y-chromosome from 93 Aksay Kazakhs samples, using a high-resolution analysis of 106 biallelic markers and 17 STRs.

Molecular genealogy of Tusi Lu's family reveals their paternal relationship with Jochi, Genghis Khan's eldest son.

Genghis Khan's lineage has attracted both academic and general interest because of its mystery and large influence. However, the truth behind the mystery is complicated and continues to confound the scientific study. In this study, we surveyed the molecular genealogy of Northwestern China's Lu clan who claim to be the descendants of the sixth son of Genghis Khan, Toghan.

Electrochemical sensor for the discrimination of bilirubin in real human blood based on Au nanoparticles/ tetrathiafulvalene -carboxylate functionalized reduced graphene oxide 0D-2D heterojunction.

In clinical practice, the excess concentration of bilirubin can trigger diseases such as neonatal jaundice, hepatic failure, septicemia, and so on. The concentration of bilirubin is one of important clinical indexes to evaluate patients with hepatic function disease in clinical practice. Therefore, it is very necessary to develop a rapid detection technique detecting the bilirubin in body fluids.

Ultra-fine Pd nanoparticles confined in a porous organic polymer: A leaching-and-aggregation-resistant catalyst for the efficient reduction of nitroarenes by NaBH.

Porous organic polymers (POPs) containing nitrogenous substituents have potential practical applications as heterogeneous catalysts based upon controlled porous structure and surface-anchored noble metal nanoparticles (NMNPs). In this work we prepared a POP material from piperazine and cyanuric chloride starting materials (PC-POP). The PC-POP material contains numerous triazinyl moieties, thus rendering the pores hydrophobic.

Efficient determination of amphetamine and methylamphetamine in human urine using electro-enhanced single-drop microextraction with in-drop derivatization and gas chromatography.

An efficient method for the determination of amphetamine (AM) and methylamphetamine (MA) using electro-enhanced single-drop microextraction (EE-SDME) and gas chromatography has been developed. One advantage of this method is that the extraction efficiency is greatly enhanced by the electric field acceleration of the mass transfer of target analytes from the sample solution to the organic solvent drop. In addition, the extracted analytes were in situ derivatized with isobutyl chloroformate (IBCF) in the droplet, which further improved the sensitivity of this method.

[Determination of six amphetamine-type stimulants in urine samples using electro-enhanced single drop microextraction-gas chromatography].

A method for the simultaneous determination of six amphetamine-type stimulants (ATSs) in urine by electro-enhanced single drop microextraction-gas chromatography (EE-SDME-GC) with a flame ionization detector (FID) was developed. The influences of the EE-SDME parameters on the extraction efficiencies were investigated. The 5 mL-samples at pH 7 were extracted with 2 μL dichloromethane for 3 min under an applied potential of -2.

[Effects of substituted functional groups of cations on retention performance of ionic liquid stationary phases in gas chromatography].

Thirteen stationary phases comprising a polyvinyl imidazolium ionic liquid (IL) in which cations containing propyl, butyl, nonyl, ethyl-phenyl, or cyan methyl functional groups are paired with bis(trifluoromethanesulfonyl) imide ([NTf]), trifluoromethanesulfonate ([TFO]), and hexafluorophosphate ([PF]) were synthesized and directly coated inside capillary fused silica tubing for use in gas chromatography. The relationship between the structure of the ILs and the McReynolds constant, thermal stability, and retention behavior of the test compound on the prepared fused silica columns was examined and discussed. The influence of the cationic substituents on retention performance of stationary phases was also studied.

Global Processing Styles Facilitate the Discovery of Structural Similarity.

This study examined whether global processing style facilitates the discovery of structural similarity. In the two experiments, the participants were presented with three stories after being primed with global or local processing through a Navon task. The first story was the base story, and the other two stories shared either surface similarity or structural similarity with the base story.

Oxidized multiwalled carbon nanotubes coated fibers for headspace solid-phase microextraction of amphetamine-type stimulants in human urine.

Carbon nanotubes (CNTs) have attracted a lot of attention as effective sorbents due to their strong sorption properties and several potential applications in many fields. In this work, the acid oxidized multiwalled carbon nanotubes (MWCNTs-COOH) was coated onto a stainless steel wire by a simple physical adhesion approach to develop solid-phase microextraction (SPME) fibers. By combination of the MWCNTs-COOH coated fiber-based headspace SPME and gas chromatography-mass spectrometry (GC-MS), the developed method demonstrates a good enhancement factor (288-651), low limits of detection (LODs, 0.

[Effects of the maca extract on the ultrastructures of mitochondria in the spinal nerve cell and exercise endurance].

Objective: To investigate the effects of maca extract on the ultrastructures of mitochondria in the spinal nerve cell and exercise endurance.

Methods: The Wistar rats were randomly divided into 5 groups, including the control group (no swimming), the swimming group (free swimming), and 3 treatment groups treated with the maca extract at the doses of 4.0, 5.

Hollow mesoporous silica nanotubes modified with palladium nanoparticles for environmental catalytic applications.

Nowadays, chemical catalytic methods for the treatment of organic wastes are attracting more and more research attention. In the current research, novel catalysts with palladium nanoparticles (Pd NPs) supported on the hollow mesoporous silica nanotubes (h-mSiO) were synthesized for the catalytic reduction of 4-nitrophenol (4-NP) and hydrodechlorination (HDC) of 4-chlorophenol (4-CP). The key point for the fabrication of the catalysts is that a certain thickness of the silica shell was wrapped on the multiwalled carbon nanotubes (MWNTs) or Pd/MWNTs through biphase stratification approach, and then the samples were calcined to remove the MWNTs.

The genetic admixture in Tibetan-Yi Corridor.

Objectives: The Tibetan-Yi Corridor located on the eastern edge of Tibetan Plateau is suggested to be the key region for the origin and diversification of Tibeto-Burman speaking populations and the main route of the peopling of the Plateau. However, the genetic history of the populations in the Corridor is far from clear due to limited sampling in the northern part of the Corridor.

Materials And Methods: We collected blood samples from 10 Tibetan and 10 Han Chinese individuals from Gansu province and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs).

The tendency of unconscious thought toward global processing style.

This study explored whether unconscious thought has a tendency to process information globally. In three experiments, a Navon task was used to activate global or local processing styles. Findings showed that in the unconscious-thought groups, those performing the local Navon task presented a poorer decision-making performance when compared to those performing the global Navon task (Experiment 1); participants reported that their judgments were made based on partial attributes (Experiment 2), and evaluated a target individual mainly based on information consistent with stereotypes (Experiment 3).

Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes.

China has repeatedly been the subject of genetic studies to elucidate its prehistoric and historic demography. While some studies reported a genetic distinction between Northern and Southern Han Chinese, others showed a more clinal picture of small differences within China. Here, we investigated the distribution of Y chromosome variation along administrative as well as ethnic divisions in the mainland territory of the People's Republic of China, including 28 administrative regions and 19 recognized Chinese nationalities, to assess the impact of recent demographic processes.

Determination of 13 Organic Toxicants in Human Blood by Liquid-Liquid Extraction Coupling High-Performance Liquid Chromatography Tandem Mass Spectrometry.

Pesticides and antidepressants are frequently misused in drug-facilitated crime because of their toxicological effect and easy-availability. Therefore, it is essential for the development of a simple and reliable method for the determination of these organic toxicants in biological fluids. Here, we report on an applicable method by the combination of optimized liquid-liquid extraction (LLE) procedure and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to identify and quantify dimethoate, omethoate, dichlorvos, carbofuran, fenpropathrin, diazepam, estazolam, alprazolam, triazolamm, chlorpromazine, phenergan, barbitone and phenobarbital in human blood.

Effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats.

The present study investigated the effects of a flavonoid extract from Cynomorium songaricum on the swimming endurance of rats by measuring changes of free radical scavenging enzymes, such as CuZn-SOD (copper, zinc-superoxide dismutase) and GSH-px (glutathione peroxidase), and body weights. Significant and dose-dependent antioxidant and anti-fatigue effects of flavonoids (rutin, catechin and isoquercitrin) on swimming rats were observed during 10 days of swimming exercise. After treatment with the flavonoid extract at doses of 0.

Cytotoxic activity of an octadecenoic acid extract from Euphorbia kansui (Euphorbiaceae) on human tumour cell strains.

We have investigated the cytotoxic and antitumour activity of an octadecenoic acid extract, mainly containing oleic and linoleic acids, from Euphorbia kansui on human gastric (SGC-7901), hepatocellular carcinoma (BEL-7402), and leukaemia (HL-60) tumour cell strains. Significant and dose-dependent antiproliferation effects were observed on tumour cells from the dose of 3.2 microg mL(-1), which were comparable with or better than those of the common antitumour agent 5-fluorouracil.

Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice.

The present study examined the effects of derivatives of galactosides and glucosides in a polysaccharide extract from Euphorbia kansui (Euphorbiaceae) on exercise-induced oxidative stress in mice. Exhaustive swimming exercise significantly increases the degree of lipid peroxidation in terms of malondialdehyde content and reduces the antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Our findings revealed that chronic oral treatment with the extract elevates enzymatic activities of SOD and GPx accompanied by a corresponding decrease in malondialdehyde.

Effects of Hydrocotyle sibthorpioides extract on transplanted tumors and immune function in mice.

This paper describes the effects of an ethanolic extract of Hydrocotyle sibthorpioides on transplanted tumors and immunologic function in mice. When the H. sibthorpioides extract was administered orally at a dose of 1.