RNF38 promotes gilteritinib resistance in acute myeloid leukemia via inducing autophagy by regulating ubiquitination of LMX1A.

Background: Gilteritinib is a commonly used targeted drug for acute myeloid leukemia (AML), but the emergence of gilteritinib resistance greatly reduces the therapeutic effect. RING finger protein 38 (RNF38), a protein with RING Finger domain and E3 ubiquitin ligase activity, has been implicated in tumorigenesis and drug resistance. However, the role and mechanism of RNF38 in the gilteritinib resistance of AML remains unclear.

Visualization Methods for DNA Sequences: A Review and Prospects.

The efficient analysis and interpretation of biological sequence data remain major challenges in bioinformatics. Graphical representation, as an emerging and effective visualization technique, offers a more intuitive method for analyzing DNA sequences. However, many visualization approaches are dispersed across research databases, requiring urgent organization, integration, and analysis.

Swiftly Manipulates the Transcriptional Regulation in During the Early Infection Stage.

spp. represent an economically important fruit tree crop worldwide. However, molecular mechanisms underlying the interaction between citrus and the remain largely unexplored.

Associations between body mass index and physical fitness indicators among Chinese university students: a multicenter cross-sectional study.

Background: Increasing body mass index (BMI) has many negative effects on the physical and mental health of university students and has become a common public health problem in all countries. However, there are few studies on the association between BMI and physical fitness indicators among Chinese university students in developing countries, and the findings are inconsistent. The present study aims to analyze the association between BMI and physical fitness indicators among Chinese university students, to assist in university students' health development and intervention.

Transcriptomic analysis reveals differential transcriptional regulation underlying Citrus Bacterial Canker (CBC) tolerance in Citrus sinensis.

The sustainable development of the citrus industry is greatly affected by citrus canker, an important bacterial disease. To explore the transcriptional regulatory mechanism of citrus resistance to canker disease, this study used the susceptible Citrus sinensis cv. 'Newhall' and its citrus canker-resistant bud mutation variety 'Longhuitian' (LHT) as materials.

Basketball robot object detection and distance measurement based on ROS and IBN-YOLOv5s algorithms.

With the combination of artificial intelligence and robotics technology, more and more professional robots are entering the public eye. Basketball robot competition, as a very good target system for autonomous robot research, is very suitable for conducting research on robot autonomous perception system object detection. However, traditional basketball robots have problems such as recognition difficulties, which seriously affect the recognition of robot targets and distance measurement based on recognition.

A near-infrared frequency upconversion fluorescent probe for rapid and sensitive visual detection of sulfur dioxide.

Inflammation is a complex physiological response involving various cellular and molecular events. Sulfur dioxide (SO), which is usually in the form of HSO and SO under physiological conditions, plays a crucial role in the regulation of inflammation and diseases. Frequency upconversion luminescence (FUCL) can realize the unique anti-Stokes process of long-wavelength excitation to short-wavelength emission; thus, it is a highly promising optical method for imaging due to its deep tissue penetration, low photo-damage, .

A Trade-Off Between Leaf Carbon Economics and Plant Size Among Mangrove Species in Dongzhaigang, China.

Plant size is closely linked to its leaf trait characteristics, which are essential for determining its form and function. These relationships constitute a fundamental component of the global spectrum of plant diversity. Despite this, the size-trait relationships in coastal mangroves have often been overlooked, with a common assumption that they would mirror those found in terrestrial tropical trees.

hUC-MSCs mitigate atherosclerosis induced by a high-fat diet in ApoE mice by regulating the intestinal microbiota.

Background: The mechanism underlying human umbilical cord mesenchymal stem cells (hUC-MSCs) regulating the stability of atherosclerotic plaque was explored by establishing mice models of atherosclerosis induced by a high-fat diet and hUC-MSCs intervention.

Methods: The ApoE mice atherosclerosis model was constructed using a high-fat diet, and mice were divided into a normal diet group (ND), high-fat diet group (HFD), hUC-MSCs treatment group (HFDM), while the blank control (BC) consisted of C57BL/6J mice. After successful establishment of the model, the feces, hearts, and aorta of mice were collected.

Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish.

Background: The dibutyl phthalate (DBP) is a member of the phthalate family and is widely used as a plasticizer in daily life and production. However, the influence of DBP on the vascular developmental remains unclear.

Methods: In this study, we used zebrafish as a model organism to investigate the effects of DBP on vascular development in vivo.

Recent advances in discrete Cu complexes for enhanced chemodynamic therapy.

Since the concept of metal ion stimulation-mediated chemodynamic therapy was proposed by Bu and Shi's group in 2016, increasing attention has been directed toward the fabrication of efficient, safe and stable Fenton/Fenton-like catalysts to advance clinical translation. In particular, metal-based complexes with inherent metal catalytic centers have received extensive attention as potential alternatives/complements for traditional CDT agents. Among them, copper-based complexes, which possess excellent redox properties, extensive adaptability and abundant availability, enable the efficient generation of ROS through Fenton-like reactions in CDT, thereby causing oxidative damage to lipids, proteins, and DNA in cancer cells.

Tuning structures and catalysis performance of two-dimensional covalent organic frameworks based on copper phthalocyanine building block and phenyl connector.

Based on the experimentally reported stable and conductive two-dimensional covalent organic frameworks with copper phthalocyanine (CuPc) as building block and cyan substituted phenyl as connector (CuCOF-CN) as an electrocatalyst for CO reduction reaction (RR), first principle calculations were performed on CuCOF-CN and its analog with the CN being replaced by H (CuCOF). Comparatively studied on the crystal structures, electronic properties, and CORR performance of the two catalysts found that CuCOF has reduced crystal unit size, more positive charge on Cu and CuPc segments, smaller band gap, and lower reaction barrier for CO RR than CuCOF-CN. CuCOF is proposed to be good potential electrocatalyst with good environment friendliness.

Comprehensive analysis and novel insights into the efficacy of polymyxin B sulfate in the treatment of sepsis caused by carbapenem-resistant gram-negative bacteria.

Objective: To investigate and analyze the clinical efficacy and safety of polymyxin B sulfate in the treatment of carbapenem-resistant gram-negative bacteria (CR-GNB) in sepsis; in order to provide reference for the clinical diagnosis, treatment and prognosis evaluation of sepsis.

Methods: The clinical data of 76 patients with CR-GNB sepsis treated with polymyxin B sulfate combined with an anti-infection regimen in the First Affiliated Hospital of Gannan Medical University from January 2020 to February 2024 were retrospectively studied. To analyze and discuss the clinical characteristics, results of the bacterial culture and drug sensitivity, clinical efficacy and prognosis of CR-GNB patients, efficacy comparison of different doses of polymyxin B sulfate treatment regimens, efficacy comparison of different combination regimens based on polymyxin B sulfate, changes in clinical indexes before and after treatment of polymyxin B sulfate, adverse drug reactions and adverse events of polymyxin B sulfate were investigated.

Salivary effector DcE1 suppresses plant defense and facilitates the successful feeding of Asian citrus psyllid, Diaphorina citri.

Background: Piercing-sucking insects secrete diverse repertoires of effectors into their hosts to weaken host defenses and promote infestation. The Asian citrus psyllid, Diaphorina citri Kuwayama, is the most destructive insect pest in citrus orchards because of its role as a vector for the huanglongbing pathogen, Candidatus Liberibacter asiaticus (CLas). However, specific effector proteins and their functions in D.

Transcriptome and WGCNA Analyses Reveal Key Genes Regulating Anthocyanin Biosynthesis in Purple Sprout of Pak Choi ( L. ssp. ).

Chinese cabbage is rich in vitamins, fibre, and nutrients and is one of the primary vegetables consumed in autumn and winter in South Asia. 'Purple pak choi' sprouts are particularly rich in anthocyanins and are favoured by consumers. However, reports on the regulation of anthocyanin synthesis in purple pak choi sprouts do not exist.

Effects of percussive massage therapy on fascia echo intensity and fascia thickness in firefighters with chronic non-specific low back pain: a randomized controlled trial.

Background: Chronic non-specific low back pain (CNSLBP) is prevalent among firefighters and may negatively affect their job performance. Alterations in the thoracolumbar fascia (TLF) structure are associated with CNSLBP. Percussive massage therapy (PT) has demonstrated potential in modifying fascial properties and alleviating pain.

Mn-activated Sc-based hexafluoride red phosphor KScF: Synthesis, luminescence, and its applications in blue-pump WLEDs.

Due to the advantages of low phonon energy, structural diversity, excellent thermal stability and optical properties, fluoride compounds have sparked considerable research attention. On this foundation, a novel red-emitting phosphor, KScF:Mn (abbreviated as KSF:Mn), was successfully designed and synthesized via a conventional co-precipitation process. The phosphor was comprehensively analyzed in terms of its phase, structure, morphology, elemental composition, and optical performance.

Modulating conjugated microporous polymers via cyclization as a remarkable photo-enhanced uranium recovery platform.

Uranium recovery is of great significance for managing environmental contamination, improving the utilization rate of uranium resources, reducing the pressure of nuclear fuel supply and building a closed-loop nuclear fuel cycle system. However, most of the current adsorbents are limited in practical application due to their poor selectivity in highly acidic environments (pH = 1). Here, we present a powerful uranium recovery strategy with combined ligand complexation, chemical reduction and photoreduction based on metal-free cyclization-modulated conjugated microporous polymers (CMPs).

Autoinducer-2 relieves soil stress-induced dormancy of Bacillus velezensis by modulating sporulation signaling.

The collective behavior of bacteria is regulated by quorum sensing (QS). Autoinducer-2 (AI-2) is a common QS signal that regulates the behavior of both Gram-positive and Gram-negative bacteria. Despite the plethora of processes described to be influenced by AI-2 in diverse Gram-negative bacteria, the AI-2-regulated processes in Bacilli are relatively unexplored.

Synergistic effect of multi-metal site provided by Ni-N, adjacent single metal atom, and Fe nanoparticle to boost CO activation and reduction.

Single transition metal (TM) atom embedded in nitrogen-doped carbon materials with M-N-C configuration have emerged as a promising class of electrocatalysts for electrochemical CO reduction (CORR). However, at high TM atom densities, a comprehensive understanding of the active site structure and reaction mechanisms remains a significant challenge, yet it is crucial for enhancing CORR performance. In this work, we use first-principles calculations to investigate the electrocatalytic performance of Ni-N sites for CO2 reduction to CO, co-assisted by neighboring TM atoms and a Fe nanoparticle.

Photocatalytic One-Pot Three-Component Reaction for the Regioselective Synthesis of Bromo-Substituted Pyrazoles.

A photocatalytic three-component cascade reaction of readily available enaminones, hydrazines, and CBr for the synthesis of bromo-substituted pyrazoles in one pot has been demonstrated. This strategy involves intermolecular C-N/C-Br bond formation and represents an efficient approach to the construction of 4-bromo-substituted pyrazoles with high regioselectivity, broad substrate scope, good functional group tolerance, convenient operation, and mild reaction conditions. Mechanistic investigations show that this reaction proceeds via intermolecular cyclization of enaminones with hydrazines, followed by a regioselective bromination of pyrazoles using CBr as a "Br" source.

Citrus exosome-modified exogenous dsRNA delivery reduces plant pathogen resistance and mycotoxin production.

Plant-derived exosome-like nanoparticles (PENs) are crucial for intercellular communication. However, PEN-based transport of pathogenic fungal genes remains unclear. This study isolated and purified PENs from lane late navel orange citrus juice by following the sucrose gradient ultracentrifugation technique.