A sensitive electrochemical sensor based on CoWO/multi-walled carbon nanotubes for the selective determination of chlorpromazine hydrochloride.

In this work, a novel electrochemical sensor based on cobalt tungstate/multi-walled carbon nanotube (CoWO/MWCNT) nanocomposites has been used to detect chlorpromazine hydrochloride (CPZ). The CoWO/MWCNT nanocomposite was obtained by solvothermal technology and ultrasonic method and analyzed using different characterization techniques such as scanning electron microscopy (SEM), X-ray diffractometry (XRD), energy-dispersive spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS). The electrochemical behavior of CoWO/MWCNT/GCE was explored using cyclic voltammetry (CV).

circFOXP1: a potential diagnostic and therapeutic target in human diseases.

Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. Among these, circFOXP1 has been implicated in various diseases, including cancers, respiratory, skeletal, and cardiovascular disorders. This review systematically examines circFOXP1's role in disease progression, highlighting its involvement in critical biological processes, including cell proliferation, invasion, apoptosis, and autophagy.

The role of miR-152 in urological tumors: potential biomarkers and therapeutic targets.

Urological malignant tumors pose a significant threat to human health, with a high incidence rate each year. Prostate cancer, bladder cancer, and renal cell carcinoma are among the most prevalent and extensively researched urological malignancies. Despite advancements in research, the prognosis for these tumors remains unfavorable due to late detection, postoperative recurrence, and treatment resistance.

RNF38 promotes gilteritinib resistance in acute myeloid leukemia via inducing autophagy by regulating ubiquitination of LMX1A.

Background: Gilteritinib is a commonly used targeted drug for acute myeloid leukemia (AML), but the emergence of gilteritinib resistance greatly reduces the therapeutic effect. RING finger protein 38 (RNF38), a protein with RING Finger domain and E3 ubiquitin ligase activity, has been implicated in tumorigenesis and drug resistance. However, the role and mechanism of RNF38 in the gilteritinib resistance of AML remains unclear.

The role of AIM2 in inflammation and tumors.

Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates the assembly of inflammasome and activates the inflammasome signaling cascade, resulting in the production of inflammatory mediators and the cleavage of Gasdermins. Consequently, these processes culminate in inflammatory responses and pyroptotic cell death.

Establishing a predictive nomogram for 21‑day transplant-free survival in drug-induced liver failure.

Background: The high prevalence of drug-induced liver failure (DILF) have drawn great attention from clinicians.

Aim: To further delineate the clinical features of DILF and develop an easily applicable nomogram, based on readily-discernable clinical data, to predict transplant-free survival (TFS) at different time points.

Methods: 202 DILF patients were enrolled between January 2016 and December 2022, and were followed up from DILF diagnosis to death, liver transplantation, or 91 days afterward, whichever came first.

Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review.

Pigeon pea ( (L.) Millsp.) is a traditional Chinese medicinal plant widely utilized in folk medicine due to its significant pharmacological and nutritional properties.

Hyaluronic Acid-Based Dynamic Hydrogels for Cartilage Repair and Regeneration.

Hyaluronic acid (HA), an important natural polysaccharide and meanwhile, an essential component of extracellular matrix (ECM), has been widely used in tissue repair and regeneration due to its high biocompatibility, biodegradation, and bioactivity, and the versatile chemical groups for modification. Specially, HA-based dynamic hydrogels, compared with the conventional hydrogels, offer an adaptable network and biomimetic microenvironment to optimize tissue repair and the regeneration process with a striking resemblance to ECM. Herein, this review comprehensively summarizes the recent advances of HA-based dynamic hydrogels and focuses on their applications in articular cartilage repair.

Age at type 2 diabetes diagnosis and the risk of mortality among US population.

To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population.

Apoptosis and long non-coding RNAs: Focus on their roles in ischemic stroke.

Ischemic stroke (IS) is a severe and sudden cerebrovascular event, associated with notably high rates of mortality and morbidity. The process of apoptosis, a genetically orchestrated form of programmed cell death, is divided into two pathways: intrinsic and extrinsic. The intricate involvement of long non-coding RNA (lncRNA) in the pathobiology of IS, particularly in modulating neuronal apoptosis, is a burgeoning area of research.

Optimization of diagnosis and treatment of hematological diseases via artificial intelligence.

Background: Optimizing the diagnosis and treatment of hematological diseases is a challenging yet crucial research area. Effective treatment plans typically require the comprehensive integration of cell morphology, immunology, cytogenetics, and molecular biology. These plans also consider patient-specific factors such as disease stage, age, and genetic mutation status.

γδ T Cell-mediated Tumor Immunity is Tightly Regulated by STING and TGF-β Signaling Pathways.

The STING pathway plays a critical role in tumor immunosurveillance. However, the precise mechanisms by which STING regulates gamma delta (γδ) T cell function during tumor progression remain unclear. Herein, we find that tumor-derived cyclic GMP-AMP (cGAMP) activates a distinct STING pathway by inducing TBK1-mediated phosphorylation of Eomes in γδ T cells during the early stage of tumor development is demonstrated.

Expanding the PD-L1 Paradigm: A Comprehensive Systematic Review and Meta-Analysis of Scoring Systems and Additional Biomarkers Influencing Immune Checkpoint Inhibitor Outcomes in Breast Cancer.

Objectives: The study aimed to conduct an in-depth analysis of the influence of PD-L1 status and expression levels and other variables on the effectiveness of immune checkpoint inhibitors (ICIs) in treating breast cancer.

Methods: A total of 19 articles, involving 16 trials and 7899 patients, were included in the analysis. The outcomes of interest were odds-ratio (OR) for pathological complete response (pCR) in early breast cancer, and hazard ratio (HR) for progression-free survival (PFS) and overall survival (OS) in advanced breast cancer.

Liposomes-mediated enhanced antitumor effect of docetaxel with BRD4-PROTAC as synergist for breast cancer chemotherapy/immunotherapy.

It has been reported that proteolysis-targeting chimeras (PROTACs) can effectively degrade intracellular oncogenic proteins, providing an ideal strategy for cancer treatment. ARV825, a bromodomain-containing protein 4 (BRD4)-PROTAC, has demonstrated the capacity to enhance the antitumor effect of the classic chemotherapeutic agent docetaxel (DTX). However, there are three major challenges to the broader in vivo application of ARV825: poor solubility, poor permeability, and off-target effects.

Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway.

Background: Non-small-cell lung cancer (NSCLC) is the primary type of lung cancer with the leading cause of fatalities from cancer, and the effective treatment is minimal. Altingia chinensis is a medicinal plant utilized as a traditional folk remedy to alleviate rheumatism, punch injury and paralysis. APE is the petroleum ether extract from A.

The mediating role of depression and disability in the association between widowhood and cognitive function among elderly Chinese individuals.

Objective: The incidence of mild cognitive impairment among the elderly in China was increasing. Widowhood, depression, and disability were significant factors that impacted cognitive function. Yet, there was currently no research, both domestically and internationally, that comprehensively examines all these factors together.

hUC-MSCs mitigate atherosclerosis induced by a high-fat diet in ApoE mice by regulating the intestinal microbiota.

Background: The mechanism underlying human umbilical cord mesenchymal stem cells (hUC-MSCs) regulating the stability of atherosclerotic plaque was explored by establishing mice models of atherosclerosis induced by a high-fat diet and hUC-MSCs intervention.

Methods: The ApoE mice atherosclerosis model was constructed using a high-fat diet, and mice were divided into a normal diet group (ND), high-fat diet group (HFD), hUC-MSCs treatment group (HFDM), while the blank control (BC) consisted of C57BL/6J mice. After successful establishment of the model, the feces, hearts, and aorta of mice were collected.

Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish.

Background: The dibutyl phthalate (DBP) is a member of the phthalate family and is widely used as a plasticizer in daily life and production. However, the influence of DBP on the vascular developmental remains unclear.

Methods: In this study, we used zebrafish as a model organism to investigate the effects of DBP on vascular development in vivo.

Fumarate hydratase-deficient renal cell carcinoma complicated with liver metastasis: case report.

Background: Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare subtype of kidney tumor. Most of them are solitary lesions, making preoperative diagnosis difficult, aggressive, and with poor prognosis. They may metastasize even at an early stage, however, there is currently no optimal diagnostic and therapeutic approach for metastatic FH-RCC.

Recent advances in discrete Cu complexes for enhanced chemodynamic therapy.

Since the concept of metal ion stimulation-mediated chemodynamic therapy was proposed by Bu and Shi's group in 2016, increasing attention has been directed toward the fabrication of efficient, safe and stable Fenton/Fenton-like catalysts to advance clinical translation. In particular, metal-based complexes with inherent metal catalytic centers have received extensive attention as potential alternatives/complements for traditional CDT agents. Among them, copper-based complexes, which possess excellent redox properties, extensive adaptability and abundant availability, enable the efficient generation of ROS through Fenton-like reactions in CDT, thereby causing oxidative damage to lipids, proteins, and DNA in cancer cells.