1,709 results match your criteria: "Gangneung-Wonju National University.[Affiliation]"

Current-vortex-sheet model of the magnetic Rayleigh-Taylor instability.

Phys Rev E

November 2024

School of Mathematics and Physics, Gangneung-Wonju National University, Gangneung 25457, South Korea.

This study investigates the Rayleigh-Taylor instability in the magnetic field applied parallel to the interface. The motion of the interface is described using a current-vortex-sheet model. The growth rate of the interface is obtained from a linear stability analysis of the model.

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Comparison of Fluid Flow Rates by Fluid Height and Catheter Size in Normal and Hypertensive Blood-Pressure Scenarios.

Healthcare (Basel)

December 2024

College of Nursing Science, Kyung Hee University, 26, Kyunghee-daero, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Objectives: This study is performed to determine the effects of fluid height, inner catheter diameter, and peripheral venous pressure on room-temperature intravenous fluid administration.

Methods: We employed the Bernoulli equation, with frictional forces considered for volumetric analysis.

Results: The results of this study demonstrate that infusion-set height, catheter size, fluid type, and blood pressure significantly affect flow rates.

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COVID-19-Related Knowledge, Fear, and Infection Control of Dental Staff.

Int J Dent Hyg

December 2024

Department of Dental Hygiene, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju, Korea.

Objective: This study aimed to investigate the correlations between knowledge, fear, infection control practices, and attitude of dental staff in Korea.

Methods: This study was conducted to investigate the correlation between COVID-19-related knowledge, fear, and infection control attitudes and practices.

Results: COVID-19-related knowledge was significantly correlated with infection control attitudes and practices (r = 0.

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Purpose: This study aimed to evaluate the validity and reliability of the Korean version of the occupational coping self-efficacy for nurses (K-OCSE-N) scale.

Methods: The English version of the OCSE-N scale was translated into Korean using a translation and back-translation process. Data were gathered from 213 nurses employed in a general hospital in South Korea.

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A taxonomic study on bdelloid rotifers collected from terrestrial habitats such as mosses and leaf litter at two different locations in Korea resulted in three new species, Habrotrocha changhoi n. sp., H.

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The morphology, morphogenesis, molecular phylogeny, and the resting cyst morphology of the freshwater ciliate, Crassohymena primicirrata (Berger and Foissner, 1987) n. gen., n.

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Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric PTH(1-34) in an osteoporotic beagle model.

Elife

December 2024

Department of Oral and Maxillofacial Surgery, Research Institute for Intractable Osteonecrosis of the Jaw, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.

This study investigates the effects of two parathyroid hormone (PTH) analogs, rhPTH(1-34) and dimeric PTH(1-34), on bone regeneration and osseointegration in a postmenopausal osteoporosis model using beagle dogs. Twelve osteoporotic female beagles were subjected to implant surgeries and assigned to one of three groups: control, rhPTH(1-34), or dimeric PTH(1-34). Bone regeneration and osseointegration were evaluated after 10 weeks using micro-computed tomographic (micro-CT), histological analyses, and serum biochemical assays.

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Host-specific effects of Eubacterium species on Rg3-mediated modulation of osteosarcopenia in a genetically diverse mouse population.

Microbiome

December 2024

Center for Natural Product Efficacy Optimization, Korea Institute of Science and Technology (KIST), Gangneung Institute of Natural Products, 679 Saimdang-Ro, Gangneung, Gangwon-Do, 210-340, Republic of Korea.

Background: Osteosarcopenia, characterized by the simultaneous loss of bone and muscle mass, is a serious health problem in the aging population. This study investigated the interplay between host genetics, gut microbiota, and musculoskeletal health in a mouse model of osteosarcopenia, exploring the therapeutic potential of gut microbiota modulation.

Methods: We examined the effects of Rg3, a phytochemical, on osteosarcopenia and its interactions with host genetics and gut microbiota in six founder strains of the Collaborative Cross (CC) population.

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Neuroprotective Effects of Chaperonin Containing TCP1 Subunit 2 (CCT2) on Motor Neurons Following Oxidative or Ischemic Stress.

Neurochem Res

November 2024

Department of Neurosurgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, 07441, South Korea.

Chaperonin containing TCP1 (CCT) is an essential protein that controls proteostasis following spinal cord damage. In particular, CCT2 plays an important role in neuronal death in various neurological disorders; however, few studies have investigated the effects of CCT2 on ischemic damage in the spinal cord. In the present study, we synthesized a cell-permeable Tat-CCT2 fusion protein and observed its effects on HO-induced oxidative damage in NSC34 motoneuron-like cells and in the spinal cord after ischemic injury.

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Excessive fluoride ions (F) in drinking water and food is harmful for human health and the environment. Therefore, a fluorescent probe tetraphenylethylene-quinoline (P-1) is developed with multiple sensing properties for the sequential detection of tert-butyldiphenylsilyl chloride (TBDS), F, and viscosity. Sensor P-1 first recognized TBDS and then observed an intramolecular charge transfer process, which produced an intermediate sensor P-2 in addition to fluorescence quenching at 576 nm.

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Disparities in Health and Oral Health Behaviors Among Adolescents from Multicultural Families in South Korea.

Inquiry

November 2024

Department of Preventive Dentistry and Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.

This study analyzed changes over time in order to identify disparities in health and oral health behaviors among adolescents from multicultural families residing in Korea. This was a cross-sectional analysis of secondary data utilizing raw data from 2011 to 2022 from the Korea Youth Risk Behavior Survey, a statistical dataset provided by the Korea Disease Control and Prevention Agency. The variables included demographic characteristics, socioeconomic characteristics, health behavior (diet, alcohol consumption, smoking), and oral health behavior (toothbrushing behavior, preventive care behavior, oral symptom experience, and school-based oral health education experience).

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A novel targeted anticancer drug delivery strategy: Cnidium officinale polysaccharide conjugated with carboxymethyl-5-fluorouracil and folic acid for ovarian cancer therapy.

Int J Biol Macromol

January 2025

Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, National Center of Important Tropical Crops Engineering and Technology Research, Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province, Wanning 571533, Hainan, China. Electronic address:

To mitigate adverse reactions induced by 5-fluorouracil (5-FU), Cnidium officinale fraction 2 (F2) polysaccharides served as the macromolecular carrier, facilitating its reaction with carboxymethyl-5-fluorouracil (C-5-FU) for producing F2-C-5-FU. Subsequently, this compound could react with folic acid (FA) through the ester bond, forming F2-C-5-FU-FA, as verified through NMR analysis. The in vitro anticancer efficacy of F2-C-5-FU-FA was evaluated using SKOV-3 cells that expressed folate receptor (FR) and FR-deficient A549 cells, showing greater cytotoxicity in the SKOV-3 cell line due to the FRs on the cell membrane.

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Background/objectives: Excessive alcohol drinking and short sleep duration could be problematic in terms of obesity. This research investigated the risk of obesity according to alcohol consumption and sleep duration, using data from the 2016-2020 Korea National Health and Nutrition Examination Survey (KNHANES).

Methods: The health behavior survey on alcohol intake and sleep duration was conducted via self-reporting by participants.

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4-Hexylresorcinol Enhances Glut4 Expression and Glucose Homeostasis via AMPK Activation and Histone H3 Acetylation.

Int J Mol Sci

November 2024

Maxillofacial and Dental Unit, Biomedical, Surgical and Oral Sciences Department, School of Dentistry, University of Milan, 20122 Milan, Italy.

This study investigates the potential of 4-hexylresorcinol (4HR) as a novel antidiabetic agent by assessing its effects on blood glucose levels, Glut4 expression, AMPK phosphorylation, and Histone H3 acetylation (Ac-H3) in the liver. In vitro experiments utilized Huh7 and HepG2 cells treated with varying concentrations of 4HR. Glut4, p-AMPK, and Ac-H3 expression levels were quantified via Western blotting.

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Oxidative stress induced by glutamate is a significant contributor to neuronal cell damage and can lead to neurodegenerative diseases such as Alzheimer's, Huntington's, and ischemic brain injury. At the cellular level, oxidative stress increases Ca ion influx and reactive oxygen species (ROS), which activate the MAPK signaling pathway. Additionally, the generation of ROS causes mitochondrial dysfunction, triggering apoptosis by promoting the translocation of AIF to the nucleus from the mitochondria.

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Phospholipids (PLs) play a crucial role in the nutraceutical field due to their various health benefits, including supporting acetylcholine production, enhancing cell membrane fluidity, and promoting cognitive functions. This study aimed to investigate the PL composition of selected agri-foods, including grains, vegetables, and fruits, and assess the effects of cooking methods. The major PLs identified in most agri-foods were phosphatidylethanolamine (PE) and phosphatidylcholine (PC).

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Aims: To explore the prevalence of depression amongst Korean nursing students and to identify the mediating effect of stress response and grit in the relationship between stress and depression in the same population.

Design: A total of 184 nursing students from Korea were included. This study was cross-sectional with a structured questionnaire that included stress, stress response, grit, and depression.

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Understanding the pathway complexity of supramolecular polymerization in biomimetic systems has been a challenging issue due to its importance in the development of rationally controlled materials and insight into self-assembly in nature. We herein report a kinetic trapping strategy as a new methodology on how to control the pathway of metallosupramolecular polymerization by employing secondary metal ions and/or ligands which form competitive complex species. For this, we proposed monoalkynylplatinum(ii) metalloligand (Pt-L) derived from a bis(amideterpyridine) receptor with one unoccupied terpyridyl terminal as a coordination site for the secondary metal ion (Ag or Fe).

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Folic-acid-targeted drug delivery system implementing Angelica gigas polysaccharide: A potential strategy for colorectal cancer treatment.

Int J Biol Macromol

December 2024

Department of Marine Food Science and Technology, Gangneung-Wonju National University, 120, Gangneung, Gangwon 210-702, Republic of Korea; East Coast Life Sciences Institute, Gangneung-Wonju National University, 120, Gangneung, Gangwon 210-702, Republic of Korea. Electronic address:

The study focuses on the development of folate-targeted conjugates utilizing Angelica gigas polysaccharide (F2) as a drug carrier for colorectal cancer therapy. We synthesized F2-C-5-FU conjugates by linking carboxymethyl-5-fluorouracil (C-5-FU) with folic acid (FA) through ester bonding. The drug release behavior of F2-C-5-FU-FA was pH-dependent, favoring release under alkaline conditions.

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miRNA-199b-5p suppresses of oral squamous cell carcinoma by targeting apical-basolateral polarity via Scribble/Lgl.

Mol Ther Nucleic Acids

December 2024

Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung-si, Gangwon-do 25457, Republic of Korea.

In epithelial cells, Scribble forms cell-cell junctions and contributes to cell morphology and homeostasis by regulating apical-basolateral polarity in mammals and functions as a tumor suppressor in many carcinomas. The initial diagnosis of oral squamous cell carcinoma is important, and its prognosis is poor when accompanied by metastasis. However, research on the mechanisms of oral squamous cell carcinoma metastasis is insufficient.

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Service Design and Evaluation of OpenNotes for Craniofacial Deformity Management in Patients and their Caregivers.

Healthc Inform Res

October 2024

Department of Plastic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Objectives: This study aimed to assess the feasibility of implementing OpenNotes in Korea. It involved developing and evaluating the Open-CHA service, which provides clinical summary information to patients diagnosed with craniofacial deformities and their caregivers following outpatient visits.

Methods: The study included 109 patients diagnosed with craniofacial deformities, along with their caregivers.

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Identification and characterization of a surfactin from Pseudomonas gessardii: A symbiotic bacterium with potent anticancer activity.

Biochem Biophys Res Commun

December 2024

Department of Marine BioScience, College of Life Science, Gangneung-Wonju National University, Gangwon-do, 25457, Republic of Korea. Electronic address:

Prasiola japonica, traditionally used as food and folk medicine in South Korea, exerts pharmacological properties, including antioxidant, anti-inflammatory, antidiabetic, and anticancer effects. In this study, we explored symbiotic microbes associated with P. japonica and identified Pseudomonas gessardii as a nonpathogenic symbiotic bacterium through 16 S rDNA sequencing.

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This study aims to analyze the trends, causes, and future prospects of aerosols in the Arctic region using ground-based observations, satellite data, and reanalysis model data. An analysis of aerosol remote sensing data from AERONET stations in the Arctic from 2000 to 2023 showed a long-term decrease in aerosol optical depth (AOD), aligning with emission regulations in Europe and North America and changes in atmospheric circulation patterns. However, the maximum AOD values observed at AERONET stations in Canada and Russia during the period of 2018-2023 were up to five times higher than the long-term average.

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Virtual surgical plan with custom surgical guide for orthognathic surgery: systematic review and meta-analysis.

Maxillofac Plast Reconstr Surg

November 2024

Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, Republic of Korea.

Background: The shift from traditional two-dimensional (2D) planning to three-dimensional (3D) virtual surgical planning (VSP) has revolutionized orthognathic surgery, offering new levels of precision and control. VSP, combined with computer-aided design/computer-aided manufacturing (CAD/CAM) technology, enables the creation of patient-specific surgical guides and implants that translate preoperative plans into more precise surgical outcomes. This review examines the comparative accuracy and operative efficiency of VSP, especially when used with custom surgical guides, against conventional 2D planning in orthognathic surgery.

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Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin, highlighting its chemical properties, mechanisms of action, and burgeoning role in psychiatric treatment. Furthermore, we examined the clinical applications and potential therapeutic benefits of psilocybin in the treatment of various mental health disorders, supported by accumulating clinical evidence.

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