Physician Deserts: Navigating the Texas Terrain of Provider Supply and Demand with GIS Mapping.

Rural health disparities in Texas impact population health due to limited healthcare access, insurance, and transportation challenges, especially in medically underserved areas. A shortage of specialists in rural regions worsens these issues, leading to increased morbidity and mortality rates. Our research aimed to address a knowledge gap by investigating the availability of three medical specialists-cardiologists, pulmonologists, and endocrinologists-in rural counties of Texas and identifying areas where access to healthcare is limited.

Factors associated with help-seeking by women facing intimate partner violence in India: findings from National Family Health Survey-5 (2019-2021).

Background: Intimate partner violence (IPV) against women has harmful effects on their psychological and physical health. However, help-seeking for IPV is significantly low among women in the Indian context. This study examines the different factors that influence help-seeking behaviour among women in India.

The role of ACE inhibitors and ARBs in preserving cognitive function via hypertension Management: A critical Update.

Hypertension poses a significant risk to cognition-related disorders like dementia. As the global population ages, age-related neurological illnesses such as Alzheimer's disease are becoming increasingly prevalent. The primary hypertension treatments, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors, exhibit neuroprotective properties.

Behcet disease presenting as large and medium vessel occlusive disease.

We hereby present a case of a 34-year-old male patient diagnosed with Behcet's disease where computed tomography revealed the presence of thrombosis and occlusion of the infrarenal aorta and bilateral renal arteries. Such a pattern of vascular involvement is an unusual and uncommon manifestation of Behcet disease.

Vulval Aggressive Angiomyxoma: A Giant Tumour Arising from Hidradenitis Suppurativa Scars.

Aggressive angiomyxoma (AA) is a very rare tumour arising from the vulvovaginal mesenchymal tissue. The literature has not reported its co-existence with hidradenitis suppurativa (HS). A 30-year-old female presented with a giant pedunculated mass arising from a scarred and disfigured perineum for 3 years.

Implications of the Gut Microbiome in Alzheimer's Disease: A Narrative Review.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with its prevalence doubling approximately every decade. It is a significant contributor to disability-adjusted life-years in individuals aged 50 and older, impacting a substantial portion of this population globally. The pathophysiology of AD is primarily explained by two hypotheses: the amyloid cascade hypothesis and the tau hypothesis.

Study of Imaging Biomarkers as a Prognostic Factor and Guide in the Management of Diabetic Macular Oedema.

Diabetic macular oedema (DME) is a major cause of vision impairment in individuals with diabetes mellitus, characterised by fluid accumulation in the macula due to increased vascular permeability. The growing prevalence of diabetes worldwide has led to an increasing burden of DME on healthcare systems. While current treatment options such as anti-vascular endothelial growth factor (anti-VEGF) injections, corticosteroids, and laser therapy exist, the variability in patient responses highlights the need for reliable prognostic tools.

Correlations of Anthropometric Measurements With Body Fat Percentage, Fat Mass, and Fat Mass Index in School-Age Children.

Background: Childhood obesity is a growing public health issue globally, including in India. Anthropometric measures such as body mass index (BMI), waist circumference, and skinfold thickness are commonly used to estimate body fat percentage (BF%), but their correlations with fat mass (FM) and fat mass index (FMI) are less emphasized. This study aimed to explore the relationships between anthropometric measurements and body fat indicators (BF%, FM, and FMI) in school-age children and obtain prediction equations for FM and FMI.

The Association of Lipid Abnormalities with Complications in Severe Scrub Typhus.

Aim: To study abnormalities of lipids in patients suffering from severe scrub typhus and their relationship with complications.

Methods: This cohort study was conducted in patients of severe scrub typhus [immunoglobulin (IgM) positive by enzyme-linked immunosorbent assay (ELISA)] admitted to our institute from 1 August 2020 through 31 July 2021. The lipid profile was estimated initially at the time of hospitalization.

Conventional Synthetic Disease-modifying Drugs Remain the Mainstay of Therapy for Rheumatoid Arthritis in India.

Background: There are limited data on the real-world utilization of disease-modifying antirheumatic drugs (DMARDs) in Indian patients with rheumatoid arthritis (RA).

Methods: This was a cross-sectional study of a multicentric observational cohort of RA patients across rheumatology clinics at six centers across India. Patients who met the American College of Rheumatology (ACR) 2010 criteria for RA were included.

Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.

Nucleic acid-based therapeutics represent a revolutionary approach in treating genetic disorders, offering unprecedented potential for addressing pathologies at their molecular level. However, effective cellular delivery remains a critical challenge hindering their clinical implementation. While existing delivery systems, including viral vectors and lipid nanoparticles, have shown utility, they face limitations in immunogenicity, cargo capacity, and manufacturing complexity.

Comparing the efficacy of oral apremilast, intralesional corticosteroids, and their combination in patients with patchy alopecia areata: a randomized clinical controlled trial.

Introduction: Alopecia areata (AA) is a chronic, immune-mediated inflammatory disorder characterized by nonscarring hair loss. The management of AA poses challenges due to its unpredictable course and variable response to treatment. In this comparative study, we evaluated the efficacy and safety of oral apremilast, intralesional corticosteroids (ILC) and a combination of both in patients with patchy AA.

Anthropometric Indices as a Predictive Screening Tool for Hypertension among Young Indian Adults.

Background: High blood pressure (BP) is increasing at an alarming rate in India and is the leading cause of cardiovascular disease. Increasing obesity is one of the risk factors for the increasing trend in hypertension among young adults.

Objectives: This study aimed to assess the comparative abilities of anthropometric indices of general and central obesity in predicting hypertension among apparently healthy young adults.

A Case of Complex Deformity of Knee Corrected by Ilizarov Fixation in a Teenage Patient.

Introduction: After the spine, the knee is the second most common location for skeletal tuberculosis. An unusual complication of tuberculosis infection is triple knee deformity. The combination of knee flexion, posterolateral tibial subluxation, and external tibial rotation over femoral condyles manifests as a severe deformity.

Crosstalk between miRNAs and signaling pathways in the development of drug resistance in breast cancer.

One of the biggest challenges of today's society is cancer, which imposes a significant financial, emotional and spiritual burden on human life. Breast cancer (BC) is one of the most common cancers that affects people in society, especially women, and due to advanced treatment strategies and primary prevention, it is still the second cause of cancer-related deaths in society. Various genetic and environmental factors are involved in the development of BC.

Efficacy and safety of a generic remifentanil formulation versus fentanyl and Ultiva during general anaesthesia: A phase III, prospective, multi-centric, observer-blind, randomised controlled trial.

Background And Aims: Remifentanil and fentanyl are potent opioid analgesics commonly used during surgery due to their distinct pharmacological profiles. This study aimed to compare the efficacy and safety of a generic remifentanil (test drug) with fentanyl and Ultiva (innovator formulation) during general anaesthesia in the Indian population.

Methods: This phase III, multi-centre (n = 13), randomised, three-arm, comparative study was conducted from 24 November 2021 to 31 March 2022.

Synergistic Clinico-Radiological Assessment of Term Newborns Afflicted by Birth Asphyxia in a Tertiary Medical Center: A Prospective Observational Study.

Background and objectives Hypoxic-ischemic encephalopathy (HIE) remains a critical concern in newborns, with therapeutic hypothermia (TH) serving as a key treatment strategy. However, assessing long-term outcomes requires a comprehensive approach, as children may develop neuropsychological and learning challenges even in the absence of noticeable motor impairments. This study aims to explore the correlation between electroencephalography (EEG) and neuroimaging findings with the clinical severity of HIE.

Transition from neonatal to paediatric intensive care of very preterm-born children: a cohort study of children born between 2013 and 2018 in England and Wales.

Objective: Following very preterm birth, some children require ongoing intensive care after the neonatal period and transition directly from neonatal units (NNUs) to paediatric intensive care units (PICUs) around term-corrected age.We aimed to understand, at a national level, characteristics and outcomes of children born very preterm who transitioned directly from NNUs to PICUs.

Design: Retrospective cohort study, using data linkage of National Neonatal Research Database, Paediatric Intensive Care Audit Network and Office for National Statistics datasets.

Reliability and efficiency of ChatGPT 3.5 and 4.0 as a tool for scalenovertebral triangle anatomy education.

Purpose: As the popularity and the usage of the artificial intelligence (AI) tools is increasing in medical education, it is important to critically evaluate these resources and confirm their reliability. The current study proposes to assess the reliability and effectiveness of ChatGPT 3.5 and 4 for gross anatomical information on scalenovertebral triangle.

Developing and validating Questionnaire for Knowledge, Attitude and Practices among the caretakers for Risk factors in Otitis media (RFOMQ-24) in children.

Purpose: The objective of this study was to develop and validate a questionnaire for analyzing Knowledge, Attitude, and Practices (KAP) about risk factors in otitis media (OM) in children among their caretakers.

Methods: The questionnaire was developed following a standardized protocol that consisted of a literature search, peer review, item generation, and expert validation, for construct, content and face validity of items in the questionnaire followed by a cross-sectional survey on 100 caretakers, this was followed by the reliability test of the items in Questionnaire.

Results: A KAP questionnaire with 24 items categorized under three domains knowledge, attitude, and practices was developed.

A Review of Photon-Counting Computed Tomography (PCCT) in the Diagnosis of Cardiovascular Diseases.

Photon-counting computed tomography (PCCT) is an innovative mechanism used for imaging and provides higher spatial resolution and contrast sensitivity in comparison with the orthodox energy-integrating detectors (EIDs). Unlike EID-based CT systems, which indirectly convert X-ray photons to electrical signals, PCCT directly counts and quantifies each photon's energy, enhancing image quality and material separation. With all of these features, PCCT is especially useful for cardiovascular imaging, where it is essential to precisely observe cardiac tissues, vascular structures, and coronary arteries.

Correlation of Trichoscopic Findings with Severity in Androgenetic Alopecia.

Background: Androgenetic Alopecia (AGA) refers to the appearance of common non-scarring progressive loss of terminal hair. Trichoscopy shows a magnified view of the hair shafts and hair follicle openings and helps us to diagnose, prognosticate and determine the disease severity.

Aims: The aim of the study was to identify the trichoscopic findings in patients with androgenetic alopecia and associate these findings with disease severity.