Supramolecular Recognition within a Nanosized "Buckytrap" That Exhibits Substantial Photoconductivity.

We report here a nanosized "buckytrap", , constructed from two bis-zinc(II) expanded-TTF (exTTF) porphyrin subunits. Two forms, and , differing in the axial ligands, HO vs tetrahydrofuran (THF), were isolated and characterized. Discrete host-guest inclusion complexes are formed upon treatment with fullerenes as inferred from a single-crystal X-ray structural analyses of with C.

Effective hydrolysis for waste plant biomass impacts sustainable fuel and reduced air pollution generation: A comprehensive review.

Among various natural biowastes availability in the environment, agricultural residues showed great impacts. It is due to huge availability and cheap carbon source, creating big challenges for their utility and systematic reduction. Objective of this review is to address the waste biomass availability and huge quantities issues and also put effort to minimize this nutrient load via biotransforming into value-added products.

Neural networks and genetic algorithm as robust optimization tools for modeling the microbial production of poly-β-hydroxybutyrate (PHB) from Brewers' spent grain.

This research work has been carried out to establish the combinatorial impact of various fermentation medium constituents, used for poly-β hydroxybutyrate (PHB) biosynthesis. Model development was performed with an optimized medium composition that enhanced the biosynthesis of PHB from the biowaste material Brewers' spent grain (BSG). The latter was used as a carbon substrate in submerged fermentation with Bacillus sphaericus NCIM 2478.

Microbial fuel cells for waste nutrients minimization: Recent process technologies and inputs of electrochemical active microbial system.

Still, in the current period, non-renewable energy sources have contributed to fulfill the current energy requirement and it causes the deficit of available stocks with emission of pollutant byproducts components. In recent years, efforts were made to harness the sustainable/ renewable fuels from renewable sources/ waste, complex organic matters including biomass at global level. Researchers have put attention on harnessing energy from wastewater and MFCs systems.

Process engineering strategy for large scale outdoor cultivation of Tetradesmus obliquus CT02 coupled with pH guided CO feeding.

A novel CO tolerant microalga Tetradesmus obliquus CT02, was previously evaluated to be a suitable bio refinery platform for synthesis of bioactive molecules, biodiesel, and biofertilizer. In the present study, a process engineering strategy was developed targeting improved growth performance of the strain at large scale under fluctuating outdoor environmental conditions. The strategy relies on maintaining pH of the culture at its optimal value via cascade control with CO feeding.

Intercalation of Nanoscale Multiferroic Spacers between the Two-Dimensional Interlayers of MXene.

We report a facile synthesis of MXene/bismuth ferrite (TiCT @ BiFeO) nanocomposites using hydrazine hydrate induced with the hydrothermal method. Preparation of the composite with hydrazine hydrate prevents the formation of BiFeO inside the matrix. The 25 wt % loading of BiFeO acts as spacers for the multilayer restacking of MXene flakes by retaining the (002) plane.

Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer.

The present treatments for lung cancer include surgical resection, radiation, chemotherapy, targeted therapy, and immunotherapy. Despite advances in therapies, the prognosis of lung cancer has not been substantially improved in recent years. Chimeric antigen receptor (CAR)-T cell immunotherapy has attracted growing interest in the treatment of various malignancies.

Cephem-Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis.

Tuberculosis (TB) is a leading source of infectious disease mortality globally. Antibiotic-resistant strains comprise an estimated 10 % of new TB cases and present an urgent need for novel therapeutics. β-lactam antibiotics have traditionally been ineffective against M.

Management of Medicines Wastage, Returned Medicines and Safe Disposal in Malaysian Community Pharmacies: A Qualitative Study.

Introduction: In supplying medicines to patients and consumers waste can occur in prescribing, dispensing, and leftover stages. Pharmacists in community pharmacies play a crucial role in dispensing and should share information on appropriate medicines disposal with consumers. This qualitative study explored how Malaysian community pharmacists manage medication wastage, returned medicines, and medicines disposal by eliciting their opinions on medicines wastage, the challenges faced, and feasibility of medicine return and safe medicine disposal in the setting of Malaysian community pharmacy.

Determination of arsenic, cadmium, mercury, lead and nickel as elemental impurities in atorvastatin calcium by inductively coupled mass spectrometer.

Atorvastatin calcium is employed as front-line treatment for cardiovascular diseases. According to the international conference on harmonization (ICH) guideline ICH Q3D, elemental impurities can come into drug products from various sources. These elemental impurities do not have any therapeutic benefit to the end-user.

Oligopyrrolic Cages: From Classic Molecular Constructs to Chemically Responsive Polytopic Receptors.

"Functional molecular systems", discrete and self-assembled constructs where control over molecular recognition, structure, bonding, transport, release, catalytic activity, etc., is readily achieved, are a topic of current interest. Within this broad paradigm, oligopyrrolic cages have garnered attention due to their responsive recognition features.

Conversion of carbon dioxide to methanol: A comprehensive review.

This review explains the various methods of conversion of Carbon dioxide (CO) to methanol by using homogenous, heterogeneous catalysts through hydrogenation, photochemical, electrochemical, and photo-electrochemical techniques. Since, CO is the major contributor to global warming, its utilization for the production of fuels and chemicals is one of the best ways to save our environment in a sustainable manner. However, as the CO is very stable and less reactive, a proper method and catalyst development is most important to break the CO bond to produce valuable chemicals like methanol.

Effectiveness of posture-correction interventions for mechanical neck pain and posture among people with forward head posture: protocol for a systematic review.

Introduction: Forward head posture (FHP) is the most common postural deviation of the upper back. It is believed to be one of the predisposing factors for the development of mechanical neck pain (MNP). We propose doing a systematic review to find the effectiveness of interventions targeted on FHP with MNP and assess implementation fidelity associated with these interventions.

Improving Structural Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Aromatic Modifications.

The thrombin binding aptamer (TBA) is a 15-mer DNA oligonucleotide (5'-GGT TGG TGT GGT TGG-3'), that can form a stable intramolecular antiparallel chair-like G-quadruplex structure. This aptamer shows anticoagulant properties by interacting with one of the two anion binding sites of thrombin, namely the fibrinogen-recognition exosite. Here, we demonstrate that terminal modification of TBA with aromatic fragments such as coumarin, pyrene and perylene diimide (PDI), improves the G-quadruplex stability.

A Compact Sensory Platform Based pH Sensor Using Graphene Field Effect Transistor.

A compact sensory platform has been fabricated using a graphene field effect transistor (GFET) to identify the biomolecules by pH sensing. The monolayer GFET is driven by an in-built top-gate for detecting the pH of the contacting buffer solution. The GFET device detects the effect of hydroxide ions on a graphite surface.

A -symmetric twisted organic salt as an efficient mechano-/thermo-responsive molecule: a reusable and sensitive fluorescent thermometer.

-Symmetric triaminoguanidinium chloride is condensed with -pentylphenothiazine carboxaldehyde to realise a thermally stable twisted organic salt on a gram scale. It appears as a nonmetallic economic salt having an integrated propeller shape with three tub-like cores and displays efficient reversible mechano- and thermo-fluorochromic behaviour. Unlike previous reports, the designed fluorescent, colorimetric thermometer works over a higher temperature range of 130-170 °C with five distinct colour variations.

Two-stage integrated process for bio-methanol production coupled with methane and carbon dioxide sequestration: Kinetic modelling and experimental validation.

The study demonstrates a two-stage integrated process for bio-methanol production using Methylosinus trichosporium NCIMB 11131, coupled with sequestration of methane and carbon dioxide. The first stage involved generation of methanotrophic biomass via sequestration of methane; which was used as biocatalyst to reduce carbon dioxide into methanol in the second stage. Maximum biomass titer of 3.

Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Extract in Colorectal Cancer Cells.

Chemotherapy is a general treatment procedure for cancer. The diversity in cancer incidence and the failure of therapy due to chemoresistance lead to increased cancer-related deaths. Therefore, new drugs with fewer secondary complications targeting diverse pathways are the need of the hour.

Intersystem Crossing in Boron-Based Donor-Spiro-Acceptor Organic Chromophore: A Detailed Theoretical Study.

Intersystem crossing and reverse intersystem crossing (rISC) processes were investigated in a boron-based donor-spiro-acceptor organic chromophore which shows thermally activated delayed fluorescence. Due to the perpendicular arrangement between donor and acceptor moieties, the HOMO and the LUMO are spatially separated, and the compound shows charge transfer (CT) transitions. We found both S and T excited states are CT in nature (i.

A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields.

We report a highly efficient green protocol for developing a novel library of 1,2,4-triazole-tagged 1,4-dihydropyridine analogs through the one-pot process from the four-component fusion of the 1-1,2,4-triazol-3-amine with different chosen aldehydes, diethyl acetylenedicarboxylate, and active methylene compounds in a water medium under microwave irradiation and catalyst-free conditions. Excellent yields (94-97%) of the target products were achieved with high selectivity with a short reaction time (<12 min) at room temperature. The structures of the synthesized pyrimidine analogs were established by NMR and HRMS spectroscopic analysis.

Solvent-Controlled Self-Assembled Oligopyrrolic Receptor.

We report a fully organic pyridine-tetrapyrrolic U-shaped acyclic receptor , which prefers a supramolecular pseudo-macrocyclic dimeric structure () in a less polar, non-coordinating solvent (e.g., CHCl).

Biotransformation of Methane and Carbon Dioxide Into High-Value Products by Methanotrophs: Current State of Art and Future Prospects.

Conventional chemical methods to transform methane and carbon dioxide into useful chemicals are plagued by the requirement for extreme operating conditions and expensive catalysts. Exploitation of microorganisms as biocatalysts is an attractive alternative to sequester these C1 compounds and convert them into value-added chemicals through their inherent metabolic pathways. Microbial biocatalysts are advantageous over chemical processes as they require mild-operating conditions and do not release any toxic by-products.

Benzo-Tetrathiafulvalene- (BTTF-) Annulated Expanded Porphyrins: Potential Next-Generation Multielectron Reservoirs.

Two sterically crowded benzo-tetrathiafulvalene (BTTF)-annulated expanded porphyrins (BTTF7-F and BTTF8) are synthesized. Detailed photophysical investigations reveal their intrinsic intramolecular charge transfer (CT) character, originated from partial electron transfer from electron-rich TTF units to the relatively electron-deficient macrocyclic core. This finding stands in contrast to what was observed in the previously reported Figure-of-eight conformer of BTTF-annulated [28]hexaphyrin (BTTF6), in which a typical π-π* electronic transition from HOMO to LUMO was observed.

Detection of Trace-Level Nitroaromatic Explosives by 1-Pyreneiodide-Ligated Luminescent Gold Nanostructures and Their Forensic Applications.

By attaching the1-pyreneiodide ancillary ligand to the surface of polyvinylpyrrolidone-stabilized gold (Au:PVP) cluster or the cetyltrimethyl ammonium bromide-stabilized gold (Au:CTAB) nanorod, a new class of luminescent mixed ligand-stabilized gold nanostructures is synthesized. This postsynthetic surface modification method followed by us is a comparatively easier and hassle-free technique to acquire surface-active luminescent "". Careful analyses of transmission electron microscopy images revealed that the sizes of these Au-clusters or Au-nanorods remain unchanged without any noticeable aggregation in the medium.