14 results match your criteria: "Gachon University 1342 Seongnam-daero[Affiliation]"

Advances and Opportunities of luminescence Nanomaterial for bioanalysis and diagnostics.

Spectrochim Acta A Mol Biomol Spectrosc

February 2025

Department of BioNano Technology, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, South Korea. Electronic address:

Article Synopsis
  • Luminescence nanomaterials (LNMs) are gaining popularity in biological analysis due to their advantageous properties like high stability, low autofluorescence, and ability to use longer-wavelength light for deeper tissue penetration, especially in techniques like upconversion nanoparticles (UCNPs).
  • The development of LNMs, particularly metal-organic frameworks (MOFs), is noteworthy for their structural flexibility and multifunctionality, enhancing bioimaging and sensor applications in various fields over the past three years.
  • The integration of LNMs into lab-on-a-chip (LOC) systems has surged, especially post-COVID-19, due to the demand for portable and efficient diagnostic tools that utilize microfluidics and biodevices in a streamlined manner
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Microfabrication is critical to the advancement of lab-on-chip devices by enabling the creation of high-precision, complex electrode structures. Traditional photolithography, commonly used to fabricate micro-patterned electrodes, involves complex and multi-step processes that can be costly and time-consuming. In this research, we present a method using 3D-printed shadow masks for electrode fabrication, offering a simpler, cost-effective alternative to traditional methods.

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Metal-organic frameworks (MOFs) have garnered substantial attention as promising candidates for electrode materials due to their intriguing electrochemical properties. However, the quest for enhanced energy density and electrical conductivity persists. Manipulating surface morphology emerges as a pivotal strategy to modulate these attributes and unlock the full potential of MOFs in electrochemical applications.

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The pursuit of efficient and sustainable energy storage solutions has fueled significant interest in the development of advanced materials for supercapacitors. Among these, two-dimensional (2D) materials undoubtingly have emerged as promising candidates due to their unique structural and electrochemical properties. To address the inherent challenges such as restacking, limited ion-accessibility, limited scalability, stability under operational conditions, and the intricate balance between surface area and conductivity that hinder the practical application of 2D materials, this article delves into innovative approaches and emerging strategies and prospects that aim to enhance their performance and durability.

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Chitosan (CS) is a natural polymer that exhibits many biological properties and is used as a biomaterial for antibacterial coatings, tissue engineering, cell research, drug delivery, and negatively charged molecule capture. In our previous study, we used a CS-polydopamine mixture to realize UV-assisted bonding between poly(methyl methacrylate) (PMMA) substrates to fabricate microdevices for self-assembled stem cell spheroid cultures. Herein, we attained reliable adhesive bonding between PMMAs using CS at room temperature assisted by oxygen plasma.

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Various fields have been identified in the "omics" era, such as genomics, proteomics, transcriptomics, metabolomics, phenomics, and metagenomics. Among these, metagenomics has enabled a significant increase in discoveries related to the microbial world. Newly discovered microbiomes in different ecologies provide meaningful information on the diversity and functions of microorganisms on the Earth.

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In this work, Ag@ZnO and Ag@ZnO/MgAC photocatalysts were synthesized using a simple two-step electrochemical method by the addition of magnesium aminoclay (MgAC) as a great stabilizer and a Lewis base, which could donate electrons for reduction of Ag and Zn ions, facilitating uniform formation as well as effective inhibition of aggregation of Ag@ZnO nanoparticles (NPs) on the MgAC matrix. Ag@ZnO and Ag@ZnO/MgAC were investigated for photocatalytic degradation of MB and their antibacterial efficiencies. Ag@ZnO/MgAC showed excellent photocatalytic MB degradation with a performance of 98.

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Multi-valued logic (MVL) circuits based on heterojunction transistor (HTR) have emerged as an effective strategy for high-density information processing without increasing the circuit complexity. Herein, an organic ternary logic inverter (T-inverter) is demonstrated, where a nonvolatile floating-gate flash memory is employed to control the channel conductance systematically, thus realizing the stabilized T-inverter operation. The 3-dimensional (3D) T-inverter is fabricated in a vertically stacked form based on all-dry processes, which enables the high-density integration with high device uniformity.

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Universal platforms for biomolecular analysis using label-free sensing modalities can address important diagnostic challenges. Electrical field effect-sensors are an important class of devices that can enable point-of-care sensing by probing the charge in the biological entities. Use of crumpled graphene for this application is especially promising.

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In this study, we have introduced a facile room-temperature strategy for irreversibly sealing polydimethylsiloxane (PDMS) elastomers to various thermoplastics using (3-aminopropyl)triethoxysilane (APTES) and [2-(3,4-epoxycyclohexyl)ethyl]trimethoxysilane (ECTMS), which can resist heat and pressure after sealing due to the high chemical reactivity of the used chemicals. An irreversible chemical bond was realized at RT within 30 min through the initial activation of PDMS and thermoplastics using oxygen plasma, followed by surface modification using amino- and epoxy-based silane coupling reagents on either side of the substrates and then conformally contacting each other. Surface characterizations were performed using contact angle measurements, fluorescence measurements, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) to verify the successful surface modification of PDMS and thermoplastics.

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Fully integrated and slidable paper-embedded plastic microdevice for point-of-care testing of multiple foodborne pathogens.

Biosens Bioelectron

June 2019

Department of BioNano Technology, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, South Korea. Electronic address:

This study presents a slidable paper-embedded plastic microdevice fully integrated with DNA extraction, loop-mediated isothermal amplification (LAMP), and colorimetric detection functionalities. The developed microdevice consists of three layers that allow a sliding movement to mix the sample and reagents for DNA purification, amplification, and detection in a sequential manner. An FTA card was employed in the main chamber for DNA extraction and purification from intact bacterial cells.

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A Plasmonic Fiber Based Glucometer and Its Temperature Dependence.

Micromachines (Basel)

October 2018

Department of Nano-Physics, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do 13120, Korea.

We present the plasmonic fiber based optical glucometer. A thin gold layer is coated on clad-free core of multimode optical fiber along 3 cm length to excite surface plasmons at 632.8 nm wavelength.

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We present the immunoassay of tau proteins (total tau and phosphorylated tau) in human sera using surface plasmon resonance (SPR) fiber sensors. This assay aimed at harvesting the advantages of using both SPR fiber sensors and a blood-based assay to demonstrate label-free point-of-care-testing (POCT) patient-friendly assay in a compact format for the early diagnosis of Alzheimer's disease (AD). For conducting the assay, we used human sera of 40 subjects divided into halves, which were grouped into AD patients and control groups according to a number of neuropsychological tests.

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Due to the rapid development of the Internet of Things (IoT), many feasible deployments of sensor monitoring networks have been made to capture the events in physical world, such as human diseases, weather disasters and traffic accidents, which generate large-scale temporal data. Generally, the certain time interval that results in the highest incidence of a severe event has significance for society. For example, there exists an interval that covers the maximum number of people who have the same unusual symptoms, and knowing this interval can help doctors to locate the reason behind this phenomenon.

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