1 results match your criteria: "Gaborone University of British Columbia[Affiliation]"
Effectiveness of Monovalent Rotavirus Vaccine After Programmatic Implementation in Botswana: A Multisite Prospective Case-Control Study.
Clin Infect Dis
May 2016
Department of Paediatrics and Adolescent Health, University of Botswana Botswana-UPenn Partnership, Gaborone University of British Columbia, Vancouver, Canada.
Article Synopsis
- Botswana introduced the RV1 rotavirus vaccine in July 2012, providing an opportunity to evaluate its effectiveness against rotavirus diarrhea hospitalizations in children under 5.
- A case-control study compared vaccinated children admitted for diarrhea (case patients) and non-rotavirus diarrhea controls, finding that full vaccination (2 doses) had a 54% effectiveness rate.
- The effectiveness varied by nutritional status, showing higher efficacy in well-nourished children (75%) compared to those with undernutrition (-28%), suggesting that undernutrition may affect vaccine effectiveness in low-income settings.