High Cryptococcal Antigenuria Prevalence in a Population of PLHIV with Neurological Symptoms Hospitalized in the Infectious Diseases Wards of the Centre Hospitalier Universitaire de Libreville, Gabon.

Cryptococcal meningitis is a major cause of death in HIV/AIDS patients due to the existence of in the central nervous system. Our objective was to evaluate the prevalence of Cryptococcus antigenuria in a population of HIV-infected patients in Libreville, Gabon. : This study was conducted from April to October 2021 at the Infectious Diseases ward of the Centre Hospitalier Universitaire de Libreville.

TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial Activity and a High Barrier to Resistance.

Malaria continues to pose a significant burden on populations in endemic areas and requires innovative treatment options. Here, we report the synthesis and preclinical evaluation of the novel 3-hydroxypropanamidine (HPA) , which shows excellent antiplasmodial activity against drug-sensitive and -resistant strains. Moreover, in various human cell lines, the compound shows no cytotoxicity and excellent parasite selectivity.

Metal accumulation in fish species of a vast hydrographic network in the Moyen-Ogooué and Haut-Ogooué Provinces of Gabon: Implications for human health.

With an obsolete livestock sector, Gabon relies on its huge hydrographic network rich in fish to supply its populations with animal proteins. This study aimed to conduct metal analyses in four fish species () frequently consumed by human populations in the Moyen-Ogooué and Haut-Ogooué Provinces of Gabon and infer the potential human health risks for those populations who rely on these freshwater produces as a source of proteins. Fish were sampled from Ezanga, Oguemoué, Onangué, Nguenè (Moyen-Ogooué) and Grand Poubara (Haut-Ogooué) Lakes during the high flow period (HF) and low flow period (LF) from 2021 to 2022, and analysed for seven heavy metals (HMs) using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) techniques.

Automated total nucleic acid extraction with magnetic beads for the detection of Plasmodium falciparum in large study cohorts.

Background: Molecular methods play an important role in clinical trials assessing anti-malarial drugs and vaccines, as well as in epidemiological studies aimed at detecting Plasmodium species, especially when dealing with large sample sizes. Molecular techniques are more sensitive and generally have a higher throughput compared to the gold standard microscopy. Further optimization can be achieved with automation of nucleic acid isolation, allowing for rapid and precise extraction.

The Development of Ebola Virus Outbreaks: A Review of Epidemiological Trends, Clinical Features, and Treatment Advances.

The Ebola virus, a filovirus that causes human Ebola virus disease (EVD), has caused multiple epidemics in the African continent for about 50 years. Wild animals were the source from which the virus was transmitted to humans, and it spread among people through direct contact. The majority of Ebola outbreaks occurred in African nations, particularly in Sudan, the Democratic Republic of the Congo (DRC), Uganda, and Gabon.

Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study.

Background: SARS-CoV-2 has been associated with a higher proportion of asymptomatic infections and lower mortality in sub-Saharan Africa than high-income countries. However, there is currently a lack of data on cellular immune responses to SARS-CoV-2 in people living in Africa compared with people in high-income regions of the world. We aimed to assess geographical variation in peripheral and mucosal immune responses.

Utility of colposcopy for the screening and management of cervical cancer in Africa: a cross-sectional analysis of providers' training and practices.

Introduction: Cervical cancer is a public health issue in Africa with devastating socioeconomic consequences due to the lack of organized screening programs. The success of screening programs depends on the appropriate investigation and management of women who test positive for screening. Colposcopic assessment following positive screening results is a noteworthy issue in Africa.

Phytochemical Analysis and Antidiarrheal Activity of Stem Bark Decoctions of Sabine (Clusiaceae).

is a medicinal plant of which bark decoctions are used in traditional medicine for the treatment of diarrhea symptoms in Gabon. The aim of the present work was to perform phytochemical and pharmacological analyses of decoctions of bark. In a principal approach, spectrophotometric analyses were used to quantify phenolic compounds, followed by liquid chromatography coupled to mass spectrometry analysis that allowed the identification of flavanone-flavone dimers as the main metabolites.

Architecting an enterprise financial management model: leveraging multi-head attention mechanism-transformer for user information transformation.

Financial management assumes a pivotal role as a fundamental information system contributing to enterprise development. Nonetheless, prevalent methodologies frequently encounter challenges in proficiently overseeing diverse information streams inherent to financial management. This study introduces an innovative paradigm for enterprise financial management centered on the transformation of user information signals.

Plasmodium knowlesi Infection Is Associated With Elevated Circulating Biomarkers of Brain Injury and Endothelial Activation.

Background: Malaria remains a major public health concern with substantial morbidity and mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge in zoonotic malaria cases and deaths in recent years. Signs of cerebral involvement have been observed in a noncomatose, fatal case of knowlesi infection, but the potential impact of this malaria species on the brain remains unexplored.

The Influence of Age, Sex, and Season on Hematological Parameters in a Captive Population of Former Laboratory Chimpanzees (Pan troglodytes).

This study aimed to establish a baseline hematological profile and examine the influence of age, sex, and season on hematological parameters in captive chimpanzees (Pan troglodytes) living in a humid tropical climate. Hematological parameters are a useful tool for assessing health status and diagnosing diseases in animals. We analyzed 473 blood samples collected from 84 chimpanzees (43 females and 41 males) during annual health checks, conducted under anesthesia for a routine physical examination.

Scratching the surface of Afrotropical Dissomphalus (Hymenoptera, Bethylidae): a revision uncovering 114 new species.

The main goal of this paper is to revise the Dissomphalus genus within the Afrotropical region. Specimens were collected across seventeen countries: Benin, Botswana, Cameroon, Central African Republic, Democratic Republic of Congo, Gabon, Guinea, Kenya, Mozambique, Namibia, Nigeria, Rwanda, South Africa, Tanzania, Uganda, Zambia and Zimbabwe. A total of 127 species have been identified in the Afrotropical region.

New records, diagnostics and preliminary checklist of the superfamily Pentatomoidea (Hemiptera: Heteroptera) from the Comoro Islands.

The following species are recorded from the Comoro Islands for the first time: 12 species of Pentatomidae: Pentatominae-Anoano pronotalis Cachan, 1952 (from Mayotte), Antestiopsis clymeneis cf. galtiei (Frappa, 1934) (Mayotte), Bagrada hilaris (Burmeister, 1835) (Mayotte), Bathycoelia rodhaini Schouteden, 1913 (Mayotte), Coquerelia ventralis Horváth, 1904 (Mayotte), Eurysaspis transversalis Signoret, 1851 (Anjouan, Grande Comore, Mayotte), Gadarscama ebenaui Reuter, 1887 (Anjouan, Grande Comore, Mohéli, Mayotte), Lerida annulicornis (Signoret, 1861) (Anjouan, Mayotte), Neoacrosternum validum (Horváth, 1904) (Grand Comore, Mayotte), Nezara viridula (Linnaeus, 1758) (Mayotte), Piezodorus hybneri (Gmelin, 1790) (Mayotte), and Stenozygum mirabile (Signoret, 1861) (Mayotte); two species of Plataspidae-Brachyplatys hemisphaerica (Westwood, 1837) (Mayotte) and Coptosoma maculatum Westwood, 1837 (Mayotte); and one species of Scutelleridae-Hotea denticulata Stål, 1865 (Mayotte). The endemic pentatomine species Bathycoelia cuneifera Bergroth, 1893, syn.

World Health Organization African Region national heads of units of diagnostics and laboratory services meetings proceedings.

Background: In the World Health Organization (WHO) African Region, many cases of serious and preventable diseases remain unmanaged because appropriate and good quality diagnostic support is not available at all levels within countries' health systems. Diagnostic and laboratory services influence the efficiency and effectiveness of both clinical and public health functions, including diagnosis, treatment, health promotion, disease prevention, surveillance and response, and research. Essential to global health security, these services are vital to decision-making processes by clinicians, epidemiologists, public health specialists, and health policymakers.

Homophily in social and demographic traits predict association patterns in female western and mountain gorillas.

Affiliative relationships are a hallmark of social relationships in gregarious mammals, but what drives variation of association patterns when kin are absent remains unknown. Gorillas, where females may disperse multiple times in their lives, provide an interesting counterpoint to female philopatric species to examine the factors influencing variation in association patterns. We examined demographic and social factors that may predict association patterns of female western (; Loango, Gabon) and mountain gorillas (; Bwindi, Uganda).

2025 Roadmap on 3D Nano-magnetism.

The transition from planar (2D) to three-dimensional (3D) magnetic nanostructures represents a significant advancement in both fundamental research and practical applications, offering vast potential for next-generation technologies like ultrahigh-density storage, memory, logic, and neuromorphic computing. Despite being a relatively new field, the emergence of 3D nanomagnetism presents numerous opportunities for innovation, prompting the creation of a comprehensive roadmap by leading international researchers. This roadmap aims to facilitate collaboration and interdisciplinary dialogue to address challenges in materials science, physics, engineering, and computing.