6 results match your criteria: "GZO-Zurich Regional Health Centre[Affiliation]"
The inflammatory spectrum of cardiomyopathies.
Front Cardiovasc Med
February 2024
Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Berlin, Germany.
Infiltration of the myocardium with various cell types, cytokines and chemokines plays a crucial role in the pathogenesis of cardiomyopathies including inflammatory cardiomyopathies and myocarditis. A more comprehensive understanding of the precise immune mechanisms involved in acute and chronic myocarditis is essential to develop novel therapeutic approaches. This review offers a comprehensive overview of the current knowledge of the immune landscape in cardiomyopathies based on etiology.
View Article and Find Full Text PDFBackground: There is an ongoing debate on how cardiac resynchronization therapy (CRT) in the presence of total AV block affects atrial fibrillation (AF) episodes and symptoms in patients with AF.
Methods: Seventy-five patients with symptomatic, drug and ablation refractory AF received, irrespective of their left ventricular ejection fraction (EF), either a CRT device and underwent subsequent atrioventricular node (AVN) ablation or already had a total AV block and underwent CRT upgrade. Long-lasting AF episodes (>48 h), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left atrial diameter (LAD), NTproBNP levels, EHRA score, and NYHA class had been monitored on the follow-up.
Diagnosis and treatment of cardiac amyloidosis. A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.
Eur J Heart Fail
April 2021
2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic.
Article Synopsis
- Cardiac amyloidosis is a serious disease caused by amyloid fibril deposits in the heart, which can arise from genetic variants or acquired conditions.
- Advances in imaging and non-invasive diagnosis show that cardiac amyloidosis is more common than previously thought.
- The paper outlines definitions of the disease, scenarios for suspicion, a diagnostic algorithm, and strategies for monitoring and treatment to improve clinical practice.
Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.
Eur Heart J
April 2021
2nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic.
Article Synopsis
- - Cardiac amyloidosis is a serious disease caused by amyloid fibril deposits in the heart, which can be linked to genetic factors or acquired conditions.
- - Recent imaging advancements have revealed that cardiac amyloidosis is more common than previously thought, leading to the need for clearer diagnostic criteria.
- - The paper outlines a diagnostic algorithm, discusses clinical scenarios for suspicion, and reviews monitoring and treatment approaches to connect recent research with clinical practice.
Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production.
Circulation
October 2013
Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada (A.V., M.N., Y.L., K.N., M.C., L.Z., P.P.L.); University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada (L.Z., G.A.W., P.P.L.); Department of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany (C.S., H.S.); and Division of Cardioimmunology, Cardiovascular Research, Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, and Department of Medicine, GZO-Zurich Regional Health Centre, Wetzikon, Switzerland (U.E.).
Background: Viral myocarditis follows a fatal course in ≈30% of patients. Interleukin-1 receptor-associated kinase 4 (IRAK4), a major nodal signal transducer in innate immunity, can play a pivotal role in host inflammatory response. We sought to determine how IRAK4 modulates inflammation and outcome in a mouse model of viral myocarditis.
View Article and Find Full Text PDFIsolated persistent left superior vena cava draining into the left atrium of an otherwise normal heart.
Eur Heart J
May 2013
Department of Medicine, GZO - Zurich Regional Health Centre, Wetzikon, Switzerland.