Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs.

Non-viral nanoparticles (NPs) have seen heightened interest as a delivery method for a variety of clinically relevant nucleic acid cargoes in recent years. While much of the focus has been on lipid NPs, non-lipid NPs, including polymeric NPs, have the possibility of improved efficacy, safety, and targeting, especially to non-liver organs following systemic administration. A safe and effective systemic approach for intracellular delivery to the lungs could overcome limitations to intratracheal/intranasal delivery of NPs and improve clinical benefit for a range of diseases including cystic fibrosis.

Ethyl cellulose matrixed poly(sulfur-co-sorbic acid) composite films: Regulation of properties and application for food preservation.

Developing non-toxic and sustainable materials with versatile and diverse functions has always been a crucial issue in food preservation packaging. Recently, inverse vulcanization has emerged as a precise and eco-friendly solution, attributed to the versatility of resulting polysulfides. In this study, a polysulfide crosslinked with sorbic acid was prepared by inverse vulcanization, and further combined with bio-macromolecular ethyl cellulose to form composite films via a casting method.

Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions.

Background And Objectives: Myelin and iron play essential roles in remyelination processes of multiple sclerosis (MS) lesions. χ-separation, a novel biophysical model applied to multiecho T2*-data and T2-data, estimates the contribution of myelin and iron to the obtained susceptibility signal. We used this method to investigate myelin and iron levels in lesion and nonlesion brain areas in patients with MS and healthy individuals.

Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastoris.

Protective vaccines are crucial for preventing and controlling coronavirus disease 2019 (COVID-19). Updated vaccines are needed to confront the continuously evolving and circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. These vaccines should be safe, effective, amenable to easily scalable production, and affordable.

Research on new magnetic epoxy resin composite slurry materials and localization grouting diffusion mechanism.

A significant number of steep cracks are frequently encountered in underground engineering, posing a threat to operation. The high-pressure grouting method is a commonly utilized repair technique. Nevertheless, conventional grout is prone to displacement due to its weight, making it challenging to ensure adequate filling of the cracks.

Layer-by-layer self-assembly coatings on strontium titanate nanotubes with antimicrobial and anti-inflammatory properties to prevent implant-related infections.

One way to effectively address endophyte infection and loosening is the creation of multifunctional coatings that combine anti-inflammatory, antibacterial, and vascularized osteogenesis. This study started with the preparation of strontium-doped titanium dioxide nanotubes (STN) on the titanium surface. Next, tannic acid (TA), gentamicin sulfate (GS), and pluronic F127 (PF127) were successfully loaded into the STN via layer-by-layer self-assembly, resulting in the STN@TA-GS/PF composite coatings.

CavitOmiX Drug Discovery: Engineering Antivirals with Enhanced Spectrum and Reduced Side Effects for Arboviral Diseases.

Advancing climate change increases the risk of future infectious disease outbreaks, particularly of zoonotic diseases, by affecting the abundance and spread of viral vectors. Concerningly, there are currently no approved drugs for some relevant diseases, such as the arboviral diseases chikungunya, dengue or zika. The development of novel inhibitors takes 10-15 years to reach the market and faces critical challenges in preclinical and clinical trials, with approximately 30% of trials failing due to side effects.

A Theoretical Exploration of the Photoinduced Breaking Mechanism of the Glycosidic Bond in Thymine Nucleotide.

DNA glycosidic bond cleavage may induce cancer under the ultraviolet (UV) effect. Yet, the mechanism of glycosidic bond cleavage remains unclear and requires more detailed clarification. Herein, quantum chemical studies on its photoinduced mechanism are performed using a 5'-thymidine monophosphate (5'-dTMPH) model.

Restriction Spectrum Imaging and Diffusion Kurtosis Imaging for Assessing Proliferation Status in Rectal Carcinoma.

Objectives: To investigate the application of the three-compartment restriction spectrum imaging (RSI) model, diffusion kurtosis imaging (DKI), and diffusion-weighted imaging (DWI) in predicting Ki-67 status in rectal carcinoma.

Methods: A total of 80 rectal carcinoma patients, including 47 high-proliferation (Ki-67 > 50%) cases and 33 low-proliferation (Ki-67 ≤ 50%) cases, underwent pelvic MRI were enrolled. Parameters derived from RSI (f, f, and f), DKI (MD and MK), and DWI (ADC) were calculated and compared between the two groups.

Expression of heterosis in photosynthetic traits in F1 generation of sorghum () hybrids and relationship with yield traits.

Heterosis is a crucial factor in enhancing crop yield, particularly in sorghum (Sorghum bicolor ). This research utilised six sorghum restorer lines, six sorghum sterile lines, and 36 hybrid combinations created through the NCII incomplete double-row hybridisation method. We evaluated the performance of F1 generation hybrids for leaf photosynthesis-related parameters, carbon metabolism-related enzymes, and their correlation with yield traits during the flowering stage.

A novel development of hybrid maximum power point tracking controller for solar pv systems with wide voltage gain DC-DC converter.

Now, the present power generation and distribution companies are working on renewable energy systems because their features are low-level atmospheric pollution, producing less greenhouse pollutants, more reliability, good static performance, and high robustness. In this work, the sunlight Photovoltaic (PV) system is selected because of its advantages are easily available in the atmosphere, high flexibility, zero carbon footprint, easy to maintain, and less transportation cost. However, solar networks produce nonlinear I-V characteristics.

Ginsenoside Re Prevents Depression-like Behaviors via Inhibition of Inflammation, Oxidative Stress, and Activating BDNF/TrkB/ERK/CREB Signaling: An In Vivo and In Vitro Study.

Depression is a widespread disease, with high mortality and recurrence rates. Recent studies have shown that elevated cytokine levels are implicated in the molecular mechanisms of depression. Oxidative stress contributes to the stimulation of cytokine production.

Selective hydrogenation of nitro compounds to amines by coupled redox reactions over a heterogeneous biocatalyst.

Cleaner synthesis of amines remains a key challenge in organic chemistry because of their prevalence in pharmaceuticals, agrochemicals and synthetic building blocks. Here, we report a different paradigm for chemoselective hydrogenation of nitro compounds to amines, under mild, aqueous conditions. The hydrogenase enzyme releases electrons from H to a carbon black support which facilitates nitro-group reduction.

Aromatic Polymethacrylates from Lignin-Based Feedstock: Synthesis, Thermal Properties, Life-Cycle Assessment and Toxicity.

There is currently a great need for rigid, high-performance and processable bio-based polymers and plastics as alternatives to the fossil-based materials used today. Here, we report on the straightforward synthesis and polymerization of lignin-derived methacrylate monomers based on the methyl esters of 4-hydroxybenzoic, vanillic, and syringic acid, respectively. The corresponding homopolymethacrylates exhibit high glass transition temperatures (Ts) at 106, 128, and 197 °C, respectively.

Improving hydrological modeling to close the gap between elevated CO concentration and crop response: Implications for water resources.

Rising atmospheric carbon dioxide concentrations ([CO]) affect crop growth and the associated hydrological cycle through physiological forcing, which is mainly regulated by reducing stomatal conductance (g) and increasing leaf area index (LAI). However, reduced g and increased LAI can affect crop water consumption, and the overall effects need to be quantified under elevated [CO]. Here we develop a SWAT-g-LAI model by incorporating a nonlinear g-CO equation and a missing LAI-CO relationship to investigate the responses of water consumption of grain maize, maize yield, and losses of water and soil to elevated [CO] in the Upper Mississippi River Basin (UMRB; 492,000 km).

Correlation between the Atherogenic Index of Plasma and Progression of Non-target Lesion Vascular Disease Following Percutaneous Coronary Intervention using Drug-eluting Stents.

Objective: To examine the correlation between Atherogenic Index of Plasma (AIP) levels and the progression of non-target lesion vascular disease following the deployment of Drug-eluting Stents (DES).

Methods: We retrospectively enrolled patients who had undergone successful treatment for CAD with DES and subsequently underwent a coronary angiography follow-up at the Cardiology Department of Tianjin Third Central Hospital from January 2017 to July 2022. The annual change in Gensini Score (GS) was calculated according to two angiographic evaluations in order to assess the progression of non-target lesion vascular disease; a change greater than 1 indicated progression, while a change of 1 or less indicated stability.

Irida-graphene phonon thermal transport non-equilibrium molecular dynamics simulations.

Recently, a new 2D carbon allotrope called Irida-Graphene (Irida-G) was proposed, and its reliable stability has been previously predicted. Irida-G is a flat sheet topologically arranged into 3-6-8 carbon rings exhibiting metallic and non-magnetic properties. In this study, we investigated the thermal transport properties of Irida-G using classical reactive molecular dynamics simulations.

A hybrid deep learning approach to solve optimal power flow problem in hybrid renewable energy systems.

The reliable operation of power systems while integrating renewable energy systems depends on Optimal Power Flow (OPF). Power systems meet the operational demands by efficiently managing the OPF. Identifying the optimal solution for the OPF problem is essential to ensure voltage stability, and minimize power loss and fuel cost when the power system is integrated with renewable energy resources.

An experimental investigation on copper square electrode wear in electric discharge machining of Hastelloy B2.

Hastelloy B2 is a high-performance nickel-molybdenum alloy and has been used in micro reactor, pump, pipe, and corrosion-resistant equipment. Square holes are required in the above application components. Although square holes are easily produced by spending more electrodes wear in Electrical Discharge Machining (EDM).

Event-triggered adaptive neural prescribed performance admittance control for constrained robotic systems without velocity measurements.

In this paper, an event-triggered adaptive neural prescribed performance admittance control (ETANPPAC) scheme is proposed to control the constrained robotic systems without velocity sensors. To ensure compliance during human-robot interaction, the reference trajectory is obtained by reshaping the desired trajectory for the robotic systems based on the admittance relationship, where a saturation function is used to constrain the reference trajectory, avoiding excessive contact forces that could render the trajectory inexecutable. Moreover, a barrier Lyapunov function is used to constrain the tracking errors for prescribed performance, where a velocity observer and a radial basis function neural network are designed to estimate the velocity and the uncertainty of the robotic systems, respectively, to enhance control performance.