2 results match your criteria: "GLP Center 1[Affiliation]"
Age and Gender Effects on Genotoxicity in Diesel Exhaust Particles Exposed C57BL/6 Mice.
Biomolecules
March 2021
Department of Chronic Disease Convergence Research, Division of Allergy and Respiratory Disease Research, Korea National Institute of Health, Chungju 28159, Korea.
There is growing evidence that the accumulation of DNA damage induced by fine particulate matter (PM) exposure is an underlying mechanism of pulmonary disease onset and progression. However, there is a lack of experimental evidence on whether common factors (age, gender) affect PM induced genomic damage. Here, we assessed the DNA damage potency of PM using conventional genotoxicity testing in old male and female mice aged 8 and 40 weeks.
View Article and Find Full Text PDFDetermination of Genotoxicity Attributed to Diesel Exhaust Particles in Normal Human Embryonic Lung Cell (WI-38) Line.
Biomolecules
February 2021
GLP Center 1, Korea Conformity Laboratories, Bio Division, Incheon 21999, Korea.
Article Synopsis
- - Several studies indicate that inhaling diesel exhaust particles (DEP) raises the risk of lung cancer, prompting research into the genetic damage caused by DEP exposure.
- - Most previous studies focused on cancerous cell models, while this research examines the impact of DEP on normal embryonic human lung fibroblast cells.
- - The findings revealed that DEP exposure leads to significant DNA damage and changes in gene expression, particularly in pathways related to responding to harmful substances and DNA repair.