Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease.

Background: No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease.

Patients And Methods: We genotyped a tetranucleotide repeat mapped in the 3'UTR of the LEP gene (LEP-tet) in 109 subjects with cardiovascular events and in 109 control subjects.

Results: Univariate analysis and multivariate logistic regression analysis adjusted for age, gender, smoking status, history of hyperlipidemia, hypertension or diabetes showed not significant association between the genotype of the LEP-tet and cardiovascular diseases.