2 results match your criteria: "GATA Haydarpasa Training Hospital Department of Internal Medicine[Affiliation]"
Increased iron and oxidative stress are separately related to cognitive decline in elderly.
Geriatr Gerontol Int
October 2011
Divisions of Internal Medicine Hematology Biochemistry, GATA Haydarpasa Training Hospital Department of Internal Medicine, Yeditepe University Hospital, Istanbul, Turkey.
Article Synopsis
- The study investigates how body iron levels and oxidative stress relate to cognitive function in elderly nursing home residents, measuring their cognitive status using the Mini-Mental State Examination (MMSE).
- Among 87 participants, those with cognitive dysfunction had higher serum iron and malondialdehyde (MDA) levels, but lower glutathione peroxidase (GSH-Px) enzyme activity compared to their cognitively normal counterparts.
- The findings suggest that elevated iron markers and oxidative stress are linked to cognitive dysfunction, yet no direct correlation was found between iron deposition and oxidative stress, indicating a need for further research on potential treatments.
Introduction And Aim: Familial Mediterranean Fever (FMF) is an autosomal recessive disease with a defect in the pyrine gene and is manifested with short attacks of inflammatory serositis, fever, and erysipelas-like skin lesions. Secondary amyloidosis is the most serious complication of the disease, in which extracellular deposits of amyloid (an amorphous and eosinophilic protein) are seen in tissues. Glycosaminoglycans are mucopolysaccharide molecules that take place in amyloid deposits with fibrillar links to amyloid.
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