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Serotonin and vasovagal syncope.

Clin Auton Res

August 2024

Department of Cardiac Sciences, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, GAA04 HRIC Building 3280 Hospital Drive Calgary, Calgary, AB, T2N 4Z6, Canada.

Purpose: The goal of this manuscript was to review the biological and clinical evidence that serotonin neurotransmission might play an important role in the  physiology and treatment of vasovagal syncope.

Methods: The authors reviewed PubMed and handsearches of secondary sources for papers related to the Bezold-Jarisch reflex and serotonin, the plausible involvement of the Bezold-Jarisch reflex in vasovagal syncope, and three lines of clinical evidence involving serotonin and the syncope.

Results: The Bezold-Jarisch reflex was first described following the infusion of veratrum alkaloids into animals in the 19th century.

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