4,358 results match your criteria: "G.W.; and Helmsley Medical Centre[Affiliation]"
Evaluation of e-Lung automated quantitative computed tomography biomarkers in idiopathic pulmonary fibrosis.
ERJ Open Res
November 2024
National Heart and Lung Institute, Imperial College, London, UK.
Article Synopsis
- The study aims to find biomarkers in idiopathic pulmonary fibrosis (IPF) that can predict adverse outcomes and help monitor disease progression over time.
- Researchers used data from two groups of IPF patients and analyzed CT imaging biomarkers to assess disease severity and their relationship with lung function and survival.
- The weighted reticulovascular score (WRVS) showed significant potential as a predictive tool, with a baseline score of ≥15% indicating a higher risk of mortality and an increase of 3% in WRVS correlating with reduced survival, surpassing traditional visual assessments of fibrosis.
Hepcidin is an essential regulator of systemic iron availability mediating both iron uptake from the diet and its release from body stores. Abnormally high hepcidin levels resulting from inflammation in chronic diseases cause iron restriction with the onset of anemia. Restoring physiological levels of hepcidin could contribute to ameliorating anemia in these patients.
View Article and Find Full Text PDFOutcomes of coronary intravascular lithotripsy for the treatment of calcified nodules: a pooled analysis of the Disrupt CAD studies.
EuroIntervention
December 2024
St. Francis Hospital, Roslyn, NY, USA.
Article Synopsis
- Coronary intravascular lithotripsy (IVL) is an effective method for stent implantation in severely calcified lesions, specifically those with calcified nodules (CNs).
- In a study of 155 patients, IVL demonstrated similar outcomes in terms of stent area and expansion, regardless of the presence of CNs, even though CNs had higher calcium volume and angle.
- The 2-year rate of target lesion failure was not significantly different between CN and non-CN lesions, suggesting that further research is needed to evaluate different treatment methods for these types of lesions.
Antibacterial -trachyloban-19-oic acid and other constituents from G.W. Hu, Ngumbau & Q.F. Wang.
Nat Prod Res
December 2024
School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston, UK.
Phytochemical analysis of the twigs and leaves of , endemic to Kenya, yielded known compounds 3-(3',4'-dimethoxyphenyl)-prop-1-ene (, 3-(3',4'-dimethoxyphenyl)-propenal (), lupeol () and -trachyloban-19-oic acid (), and a tentatively new -clerodane diterpenoid, crotokinondoenolide (). -Trachy-loban-19-oic acid () showed good activity against a panel of drug-resistant strains of and spp with MIC -values of 25 g/mL.
View Article and Find Full Text PDFFamilial Hypercholesterolemia and Cardiovascular Outcomes Amongst Younger Patients Undergoing Coronary Bypass Surgery.
Heart Lung Circ
January 2025
Royal Hobart Hospital, Hobart, Tas, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tas, Australia. Electronic address:
Background: Familial hypercholesterolemia (FH) is an under-recognised but common genetic condition resulting in elevated levels of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature coronary disease. The prevalence of FH among younger patients undergoing coronary bypass surgery is unknown, as is their post-surgical prognosis.
Method: This was a retrospective analysis of younger patients (aged <60 years) undergoing coronary bypass surgery at an Australian tertiary hospital between 2008 and 2022.
Background: The Minnesota Statewide Healthcare Coordination Center requested that the Minnesota Critical Care Working Group (CCWG) and Ethics Working Group (EWG), comprising interprofessional leaders from Minnesota's 9 largest health systems, plan and coordinate critical care operations during the COVID-19 pandemic, including the fall 2021 surge.
Research Question: Can a statewide working group collaboratively analyze real-time evidence to identify crisis conditions and to engage state leadership to implement care processes?
Study Design And Methods: The CCWG and EWG met via videoconferencing during the severe surge of fall 2021 to analyze evidence and plan for potential crisis care conditions. Five sources of evidence informed their actions: group consensus on operating conditions, federal teletracking data, the Medical Operations Coordination Center (MOCC) patient placement data, and 2 surveys created and distributed to hospitals and health care professionals.
Declining Trend of Sudden Cardiac Death in Younger Individuals: A 20-Year Nationwide Study.
Circulation
November 2024
Department of Cardiology, Copenhagen University Hospital-Rigshospitalet, Denmark (C.J.H., J.S., P.E.W., T.H.L., R.G., B.G.W., J.T.-H.).
Article Synopsis
- The study analyzes sudden cardiac death (SCD) trends in young people (1-35 years) in Denmark from 2000 to 2019, finding a significant overall decline in SCD incidence, decreasing by 3.31% annually.
- It highlights that while witnessed SCD rates dropped significantly, unwitnessed cases remained stable, leading to a 79% increase in the proportion of unwitnessed SCDs.
- Additionally, survival rates after out-of-hospital cardiac arrest (OHCA) improved from 3.9% to 28% primarily due to more bystander CPR and defibrillator use.
Metabolomics analysis reveals resembling metabolites between humanized γδ TCR mice and human plasma.
Sci Rep
November 2024
InGenious Targeting Laboratory, 2200 Smithtown Avenue Ronkonkoma, Ronkonkoma, NY, 11779, United States of America.
Gamma delta (γδ) T cells, which reside in mucosal and epithelial tissues, are integral to immune responses and are involved in various cancers, autoimmune, and infectious diseases. To study human γδ T cells to a translational level, we developed γδ humanized TCR-T1 (HuTCR-T1) mice using our TruHumanization platform. We compared the metabolomic profiles from plasma samples of wild-type (WT), γδ HuTCR-T1 mice, and humans using UHPLC-MS/MS.
View Article and Find Full Text PDFProlonged Venous Transit on Perfusion Imaging is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions.
AJNR Am J Neuroradiol
November 2024
From the Department of Radiology (M.K.), Cooper Medical School of Rowan University, Camden, NJ, USA; Department of Radiology (J.Y.M., H.A.S., M.S., H.L., V.S.Y), Department of Neurosurgery (R.X.), and Department of Neurology (V.C.U., E.B.M., R.L., M.B., R.H.L, A.E.H), Johns Hopkins Hospital, Baltimore, MD, USA; Department of Radiology (D.A.L.), West Virginia University Medicine, Morgantown, WV, USA; Department of Neuroradiology (A.A.D.), Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA; Department of Radiology (A.G.), Universite Libre De Bruxelles Hospital, Erasme, Belgium; Department of Radiology (J.J.H., B.P.), Department of Neurology (G.W.A.), Stanford University School of Medicine, Stanford, CA, USA; Department of Radiology (D.W.), Brown University/Rhode Island Hospital, Providence, RI, USA; Department of Radiology (T.D.F.), University Medical Center Munster, Munster, Germany; Department of Radiology (V.V.), Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; Department of Radiology (A.S.), Department of Neurology (Y.A.), University of Cincinnati, Cincinnati, OH, USA; Department of Radiology and Biomedical Imaging (K.N.), University of California San Francisco, San Francisco, CA, USA.
Background And Purpose: Prolonged venous transit (PVT+) is a marker of venous outflow; it is defined as the presence or absence of time-to-maximum ≥10 seconds timing in either the superior sagittal sinus or torcula. This novel perfusion imaging-based metric has been associated with higher odds of mortality and lower odds of functional recovery. This study aims to assess the relationship between PVT on admission perfusion imaging and length of hospital stay in large vessel occlusion strokes successfully reperfused with mechanical thrombectomy.
View Article and Find Full Text PDFDetermining Line of Therapy from Real-World Data in Non-Small Cell Lung Cancer.
Pharmacoepidemiol Drug Saf
December 2024
Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
Cerebral amyloid angiopathy impacts neurofibrillary tangle burden and cognition.
Brain Commun
November 2024
Dr. John T Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Cerebral amyloid angiopathy commonly co-occurs with amyloid β plaques and neurofibrillary degeneration and is proposed to contribute to cognitive impairment. However, the interplay among these pathologic changes of Alzheimer disease is not well understood. Here we replicate and extend findings of a recent study that suggested the association of cerebral amyloid angiopathy and cognitive impairment is mediated by neurofibrillary degeneration.
View Article and Find Full Text PDFMelatonin treatment increases skin microbiota-derived propionic acid to alleviate atopic dermatitis.
J Allergy Clin Immunol
November 2024
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:
Background: Melatonin has been reported to relieve the inflammatory symptoms and improve sleep disturbance in patients with atopic dermatitis (AD). Recent studies showed that melatonin produced beneficial effects by remodeling intestinal microbiota composition; however, whether the beneficial effects of melatonin in AD were mediated by the modulation of skin microbiota remains unclear.
Objective: We sought to investigate the mechanism by which melatonin treatment-induced changes in the skin microbiota composition further alleviated AD.
The cortical vein opacification score (COVES) is independently associated with DSA ASITN collateral score.
AJNR Am J Neuroradiol
November 2024
From the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.Y.), and Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD, USA; Department of Neuroradiology (D.A.L., S.A., M.K., A.T.R.), and Department of Biostatistics (S.W.), West Virginia University, Morgantown, WV, USA; Cooper Medical School of Rowan University (M.K.), Camden, NJ, USA; Department of Neurology (J.J.H., G.W.A.), Stanford University, Stanford, CA, USA; Department of Radiology (A.A.D.), Harvard Medical School, Boston, MA, USA; Department of Radiology, Neuroendovascular Division (T.D.F.), University Medical Center Münster, Germany; Department of Neuroradiology (M.W.), MD Anderson Medical Center, Houston, TX, USA; Department of Radiology (K.N.), University of California San Francisco, CA, USA.
: Pretreatment CTA-based Cortical Vein Opacification Score (COVES) has been shown to predict good functional outcomes at 90 days in patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO). This is thought to be related to its ability to measure collateral status (CS). However, its association with the reference standard test, the DSA-based American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score, has yet to be established.
View Article and Find Full Text PDFMutation burden and anti-PD-1 outcomes are not universally associated with immune cell infiltration or lymphoid activation.
Cancer Cell
December 2024
Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
Contemporary Outcomes of TAVR Using a Balloon-Expandable Valve in Patients With Severe Mitral Stenosis: Insights From the Transcatheter Valve Therapies Registry.
Circ Cardiovasc Interv
December 2024
Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (G.W.R., R.P., A.K., S.R.K.).
Article Synopsis
- This study investigated the effect of mitral stenosis (MS) on outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) with modern balloon-expandable valves, using data from over 327,000 patients across multiple centers.
- It was found that while patients with severe MS initially had worse outcomes, when matched for similar characteristics, their 30-day outcomes were similar to those with mild or less MS, except for a higher rate of pacemaker implantation.
- However, by three years post-TAVR, patients with severe MS showed a significantly higher mortality rate compared to those with mild or less MS, suggesting long-term risks associated with severe MS.
Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.
N Engl J Med
November 2024
From the Neurovascular Center (J. Liu, Q.Z., P.Z., L.C., Yongxin Zhang, F.S., Y. Wu, G.D., N.L., X.X., Zifu Li, Y. Zhou, L.Z., D.D., Yongwei Zhang, R.Z., Y.X., Q.L., P.Y.), Trauma Center (J. Liu, Q.Z.), and Department of Radiology (B.T.), Naval Medical University Changhai Hospital, the Key Laboratory of Molecular Neurobiology of the Ministry of Education, Naval Medical University (J. Liu, P.Y.), the Oriental PanVascular Devices Innovations College, University of Shanghai for Science and Technology (J. Liu, H.Z., P.Y.), the Departments of Neurosurgery (W.N., H.Y., J.Y., Z.D., J.H., Q.Y., G.W., C.G., X.W., H.J., J.S., Y.G., Y.M.) and Neurology (X.C., Z.W.), and the National Center for Neurological Disorders (Y.G., Y.M.), Fudan University Huashan Hospital, the Department of Neurosurgery, Fudan University Huashan Hospital North (Y. Lei, Yanjiang Li, L.X.), Neurosurgical Institute Fudan University and Shanghai Clinical Medical Center of Neurosurgery (Y.G., Y.M.), the Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (X.H.), the Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (J. Wan), the Department of Neurosurgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Yi Li), and the Department of Neurosurgery, Shanghai Tenth People's Hospital (L.G.), Shanghai, the Department of Neurosurgery, First People's Hospital of Changzhou, Changzhou (Y.P.), the Department of Neurosurgery, First Affiliated Hospital of Ningbo University, Ningbo (Z. Lin), the Department of Neurosurgery, Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu (Zhenbao Li), the Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng (J. Wang), the Department of Neurosurgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou (Y. Zhen), the Department of Neurosurgery, First Affiliated Hospital of Anhui Medical University, Hefei (J. Luo), the Department of Neurosurgery, First Affiliated Hospital of Fujian Medical University, Fuzhou (Y. Lin), the Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong (J.C.), the Department of Neurosurgery, Jiangsu Provincial Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing (H.L.), the Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou (M.Z.), the Department of Neurosurgery, Shantou Central Hospital, Shantou (M.L.), the Department of Neurosurgery, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou (J.Z.), the Department of Neurosurgery, Capital Medical University Beijing Chaoyang Hospital, Beijing (Y. Wang), the Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou (T.L.), the Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang (G.M.), the Department of Neurosurgery, Zhongnan Hospital Wuhan University, Wuhan (W.Z.), the Department of Neurosurgery, the First Hospital of Hebei Medical University, Shijiazhuang (C.L.), and the Department of Neurosurgery, Zhongshan Hospital Xiamen University, Xiamen (E.C.) - all in China; the Departments of Diagnostic Imaging (J.M.O.), Radiology (M.G.), and Clinical Neurosciences (M.G.), University of Calgary, Calgary, AB, Canada; and the Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam (C.B.L.M.M.).
Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.
Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.
"Scientists are People too": Biology Students Relate More to Scientists When They are Humanized in Course Materials.
CBE Life Sci Educ
December 2024
Department of Biological Sciences, Auburn University, Auburn, AL 36849.
Featuring scientists in classroom materials provides opportunities for students to relate to scientists as role models and see themselves in science. However, it is unclear what information students find most relatable when encountering scientists throughout their education. In this study, we manipulated the amount and type of information provided about scientists featured in biology courses.
View Article and Find Full Text PDFAntibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.
N Engl J Med
November 2024
From the Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (N.D.), Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (A.R.), the Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (R. Pinto); the Department of Infectious Diseases, Monash University, Clayton, Melbourne, VIC, Australia (B.A.R.), the Department of Intensive Care, Monash Medical Centre, Melbourne, VIC, Australia (Y.S.); the Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand (R. Parke); the Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada (D.C.); the Intensive Care Department, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (Y.A.); the Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada (J. Muscedere), the Department of Critical Care Medicine, Royal Columbian Hospital, Vancouver, BC, Canada (S. Reynolds), Critical Care Medicine, Capital District Health Authority, Dalhousie University, Halifax, NS, Canada (R.H.); Monash Medical Centre, Clayton, VIC, Australia (D.B.D.); Critical Care Medicine, Auckland City Hospital, New Zealand (C. McArthur), the Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand. (S. McGuinness); the Infectious Diseases Unit, Sheba Medical Center, Ramat-Gan, and Faculty of medicine, Ramat-Aviv, Tel-Aviv, Israel (D.Y.); Infectious Diseases, University Health Network, University of Toronto, Toronto (B.C.); Critical Care Medicine, North York General Hospital, Toronto (A.G., P.S.), Infectious Diseases, North York General Hospital, Toronto (P. Das), Critical Care Medicine, Mount Sinai Hospital, Unity Health Toronto, Toronto (M. Detsky), the Department of Medicine, University of Toronto, Toronto (A.M.); Sinai Health, Division of General Internal Medicine, Toronto, Toronto (M.F.), Infectious Diseases, Michael Garron Hospital, University of Toronto, Toronto (J.E.P.), Infectious Diseases, Michael Garron Hospital, Toronto (C. Kandel), Critical Care Medicine and Infectious Diseases, University of Alberta, Edmonton, Canada (W.S.), Department of Critical Care Medicine, University of Alberta and Alberta Health Services, Edmonton, Canada (S.M.B.), the Department of Medicine, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada (N.S.), the Department of Anaesthesia, Hamilton General Hospital, McMaster University, Hamilton, ON, Canada (E.B.-C.), the Faculty of Health Sciences, Hamilton General Hospital, McMaster University, Hamilton, ON, Canada (R.W.), the Departments of Surgery and Critical Care, McGill University Health Center, Montreal (K.K.); the Departments of Infectious Diseases and Pathology, Middlemore hospital, University of Auckland, New Zealand (S. Morpeth), Organ Donation New Zealand, New Zealand Blood Service, Auckland, New Zealand (A. Kazemi), Intensive Care Medicine, Middlemore Hospital, Auckland, New Zealand (A.W.); the Division of Infectious Diseases, Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa (D.R.M.), the Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa (L.M.), Niagara Health Knowledge Institute, Niagara Health, St. Catharines, ON, Canada (J.T.), the Department of Medicine, Université de Sherbrooke, QC, Canada (F. Lamontagne); the Department of Microbiology and Infectious Diseases, Université de Sherbrooke, QC, Canada (A.C.), Surgery and Critical Care Medicine, Unity Health Toronto, University of Toronto, Toronto (J. Marshall); Critical Care and Medicine, Unity Health Toronto-St. Michael's Hospital, University of Toronto, Toronto (J.O.F.), Critical Care Medicine, Unity Health Toronto, Toronto (R.C.), the Department of Medicine, Unity Health Toronto, Toronto (M. Downing), the Department of Medicine, Infectious Diseases, Trillium Health Partners, University of Toronto, Toronto (C.G.); the School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia (J.D.); the Division of Critical Care, Department of Medicine, McMaster University, Hamilton, ON, Canada (E.D.), St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, ON, Canada (J.N.), the Department of Medicine (Infectious Diseases), Queen's University, Kingston, ON, Canada (G.E.); the Department of Medicine, King Faisal Specialist Hospital and Research Center, Al Faisal University, Jeddah, Saudi Arabia (B.A.), the Department of Pathology and Laboratory Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (S.A.); the Department of Medicine, University of Western Ontario, London, Canada (C. Martin); the Department of Medicine, London Health Sciences Centre, London, ON, Canada (S.E.), the Department of Medicine, Western University, London, ON, Canada (I.B.), the Department of Medicine, Université Laval, Quebec, QC, Canada (F. Lauzier), the Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Université Laval, Quebec, QC, Canada (A.T.), the Population Health and Optimal Health Practice Research Unit, Centre Hospitalier Universitaire de Québec-Université Laval Research Center, Québec, QC, Canada (A.T.), the Department of Critical Care, University of Calgary Cumming School of Medicine, Calgary, AB, Canada (H.T.S.), the Department of Medicine, University of Calgary and Alberta Health Services (Calgary), Calgary, AB, Canada (J.C.), the Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal (E.G.M.), the Division of Infectious Diseases, Department of Medicine, McGill University, Montreal (T.C.L.); the Department Infectious Diseases, St. George Hospital, UNSW Medicine and Health, Sydney (R.S.); the Divisions of Infectious Diseases and Medical Microbiology, University of British Columbia, Vancouver, Canada (J.G.); the Intensive Care Unit, Rabin Medical Centers, Tel Aviv University, Tel Aviv, Israel (I.K.); the Intensive Care Research Programme, Medical Research Institute of New Zealand, Wellington, New Zealand (P.Y.), Medical Research Institute of New Zealand, Wellington, New Zealand. (C.L.); the Department of Infectious Diseases, Redcliffe Hospital, Redcliffe, QLD, Australia (K.O.), Infectious Diseases, Redcliffe Hospital, University of Queensland, Redcliffe, Australia (M.E.), Infectious Diseases, Sunshine Coast University Hospital, Sunshine Coast University Hospital, Birtinya, QLD, Australia (K.C.); Medicine, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montreal (P.A.); the Department of Anaesthesia, Rotorua Hospital, Rotorua, New Zealand (U.B.); Infectious Diseases, William Osler Health System, Brampton, ON, Canada (T. Havey), Critical Care Medicine, William Osler Health System, Brampton, ON, Canada (A.B.); the Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland (J.P.); Brantford General Hospital, McMaster University, Brantford, ON, Canada (B.R.); the Intensive Care Unit, Fiona Stanley Hospital, University of Western Australia, Murdoch, WA, Australia (E.L.); the Department of Medicine, University of Manitoba, Winnipeg, Canada (S.L.), the Division of Critical Care Medicine and Infectious Diseases, Health Sciences Centre, University of Manitoba, Winnipeg, Canada (A. Kumar), the Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada (R.Z.); the Infectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel (T. Hoffman); the Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia. (D.P.); Infectious Diseases, Memorial University, St. John's, NL, Canada (P. Daley); General and Subspecialty Medicine, Grampians Health Ballarat, Ballarat, VIC, Australia (R.J.C.); Service des soins intensifs, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal (E.C.), Critical Care Medicine, CIUSSS MCQ CHAUR, University of Montreal, Montreal (J.-F.N.); Clinical Microbiology and Infection Prevention and Control, Auckland Hospital, Auckland, New Zealand (S. Roberts); the Department of Intensive Care Medicine, Frankston Hospital, Frankston, VIC, Australia (R.T.), the Department of Intensive Care Medicine, Monash University, Melbourne, VIC, Australia (S.G.); the Department of Critical Care, Island Health Authority, Royal Jubilee Hospital, British Columbia, Victoria, Canada (G.W.); Infectious Diseases, Wollongong Hospital, Wollongong, NSW, Australia (O.S.), Infectious Diseases, Wollongong Hospital, University of Wollongong, Wollongong, NSW, Australia (S. Miyakis); the Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada (P. Dodek), Infectious Diseases, Richmond Hospital, Richmond, BC, Canada (C. Kwok), and the Interdepartmental Division of Critical Care Medicine, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto (R.A.F.).
Background: Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain.
Methods: In a multicenter, noninferiority trial, we randomly assigned hospitalized patients (including patients in the intensive care unit [ICU]) who had bloodstream infection to receive antibiotic treatment for 7 days or 14 days.
Clinical and Genetic Analysis of 8 Children With Ornithine Transcarbamylase Deficiency: Two Novel Mutations.
Neurol Genet
December 2024
From the Department of Pediatrics (C.Z., J. Shan, J. Su, G.W., R.X., M.D.), Qilu Hospital of Shandong University; Department of Respiratory Disease (J. Su), Children's Hospital affiliated to Shandong University, Jinan; and Department of General Practice (Q.H.), Fourth People's Hospital of Jinan, China.
Background And Objectives: Cases and studies of neurologic symptoms in children caused by genetic metabolic diseases have been widely reported. Ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle disorder, which is due to mutations in the OTC gene located on chromosome Xp21.1.
View Article and Find Full Text PDFLow-Density Lipoprotein Cholesterol Level Distributions Across Different Ages: Implications for Screening Children for Severe and Familial Hypercholesterolemia.
Circulation
November 2024
Division of General Medicine, Columbia University Irving Medical Center, New York, NY (B.K.B., A.E.M., Y.Z.).
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.
N Engl J Med
November 2024
From the Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, and the National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of China, National Research Center for Translational Medicine, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics (Y.B., M.L., J.L., T.W., R.Z., Y.C., M.X., S.W., J.N., Z.Z., J.D., G.N., Y.X., W.W.), the Lifecycle Health Management Center (Jingya Wang), and the Ruijin-Junshi Clinical Research Center (L.L.), Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, and the School of Clinical Medicine, Shanghai University of Medicine and Health Sciences (J.N.), Shanghai, the Department of Endocrine and Metabolic Diseases, Third People's Hospital of Datong (Y.L.), and the Department of Endocrine and Metabolic Diseases, Heji Hospital Affiliated to Changzhi Medical College (X.N.), Shanxi, the Department of Endocrine and Metabolic Diseases, First People's Hospital of Loudi (T.L.), and the Department of Endocrine and Metabolic Diseases, People's Hospital of Liuyang (X.Q.), Hunan, the Department of Endocrine and Metabolic Diseases, Third Hospital of Nanchang, Jiangxi (P.D.), the Department of Endocrine and Metabolic Diseases, General Hospital of Hebi Coal Industry Group (F.X.), the Department of Endocrine and Metabolic Diseases, People's Hospital of Zhengzhou (Q.D.), the Department of Endocrine and Metabolic Diseases, People's Hospital of Anyang City (X.W.), the Department of Endocrine and Metabolic Diseases, Zhengzhou Central Hospital (Z.K.), and the Department of Endocrine and Metabolic Diseases, General Hospital of Pingmei Shenma Group (H.Z.), Henan, the Department of Endocrine and Metabolic Diseases, Yankuang New Journey General Hospital (Ailiang Wang), the Department of Endocrinology, Second Affiliated Hospital of Shandong First Medical University (Xinhuan Zhang), the Department of Endocrine and Metabolic Diseases, Weifang Municipal Official Hospital (Jing Wang), the Department of Endocrine and Metabolic Diseases, Jinan Central Hospital Affiliated to Shandong First Medical University (S.P.), the Department of Endocrine and Metabolic Diseases, Weifang Hi-tech Zone People's Hospital (Xiaoliang Zhang), the Department of Endocrine and Metabolic Diseases, Second Hospital of Shandong University (S.C.), and the Department of Endocrine and Metabolic Diseases, Shanghe County People's Hospital (Z.G.), Shandong, the Department of Endocrine and Metabolic Diseases, Tieli People's Hospital (Y.N.), the Department of Endocrine and Metabolic Diseases, Yian County Hospital of Traditional Chinese Medicine (C.L.), and the Department of Endocrine and Metabolic Diseases, Wuchang People's Hospital (W.T.), Heilongjiang, the Department of Endocrine and Metabolic Diseases, Anqing Shihua Hospital of Nanjing Drum Tower Hospital Group (An Wang), and the Department of Endocrine and Metabolic Diseases, Lai'an Jia Ning Hospital (S.D.), Anhui, the Department of Cardiology, Zhongshan Hospital, Fudan University (Xiamen branch), Fujian (S.W.), the Department of Endocrine and Metabolic Diseases, Jilin Municipal People's Hospital (H.P.), and the Department of Endocrine and Metabolic Diseases, First Hospital of Jilin University (G.W.), Jilin, the Department of Endocrine and Metabolic Diseases, Hai'an People's Hospital (X.Y.), and the Department of Endocrine and Metabolic Diseases, Sheyang County Diabetes Hospital (Y.D.), Jiangsu, the Department of Endocrine and Metabolic Diseases, Affiliated Hospital of Southwest Medical University, Sichuan (Q.W.), the Department of Endocrine and Metabolic Diseases, Yuhuan Second People's Hospital, Zhejiang (Q.Z.), and the Department of Endocrine and Metabolic Diseases, Second Hospital of Dalian Medical University, Liaoning (H.L.) - all in China; and the O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas (J.H.).
Article Synopsis
- A study was conducted to find out the best systolic blood pressure targets for patients over 50 with type 2 diabetes and high cardiovascular risk, comparing intensive treatment (target <120 mm Hg) to standard treatment (target <140 mm Hg) over 5 years.
- Out of 12,821 patients, the intensive treatment group had a lower average systolic blood pressure after one year (121.6 mm Hg) compared to the standard group (133.2 mm Hg), resulting in significantly fewer major cardiovascular events.
- Despite the lower overall events in the intensive group, there were more cases of symptomatic hypotension and hyperkalemia, but the rates of serious adverse events were similar in both groups.
TRPM8 Mutations Associated With Persistent Pain After Surgical Injury of Corneal Trigeminal Axons.
Neurol Genet
December 2024
From the Department of Neurology (M.-R.G., S.T., A.M.A., X.C., J.-H.Y., B.R.S., S.D.D.-H., S.G.W.), Yale University School of Medicine, New Haven; Center for Neuroscience and Regeneration Research (M.-R.G., P.R.E., S.T., A.M.A., X.C., J.-H.Y., B.R.S., S.D.D.-H., S.G.W.), Yale University, New Haven; Neuro-Rehabilitation Research Center (M.-R.G., P.R.E., S.T., A.M.A., X.C., J.-H.Y., B.R.S., S.D.D.-H., S.G.W.), Veterans Affairs Connecticut Healthcare System, West Haven; Department of Anesthesiology (P.R.E.), Yale University School of Medicine, New Haven, CT; and Department of Ophthalmology (D.S.J.), Massachusetts Eye and Ear, Harvard Medical School, Boston.
Background And Objectives: Despite extensive efforts, the mechanisms underlying pain after axonal injury remain incompletely understood. Pain following corneal refractive surgery offers a valuable human model for investigating trigeminal axonal injury because laser-assisted in situ keratomileusis (LASIK) severs axons of trigeminal ganglion neurons innervating the cornea. While the majority of patients are pain-free shortly after surgery, a minority endure persistent postoperative ocular pain.
View Article and Find Full Text PDFMismatch Vs No Mismatch in Large Core-A Matter of Definition.
Clin Neuroradiol
November 2024
Department of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Article Synopsis
Association of Pretreatment Perfusion Imaging Parameters With 90-Day Excellent Functional Outcomes in Anterior Circulation Distal Medium Vessel Occlusion Stroke.
AJNR Am J Neuroradiol
November 2024
From the Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA (H.A.S., J.M., L.L., V.C.U., E.B.M., R.L., A.E.H., H.L., R.X., V.Y.); Department of Neuroradiology, MD Anderson Medical Center, Houston, TX 77030, USA (H.A.S., M.W.); Renaissance School of Medicine at Stony Brook University (V.V.); Department of Radiology, West Virginia University, Morgantown, WV, USA (D.A.L., A.B.); Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH (Y.A.); Neuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA (A.A.D.); Neurovascular Centre, Departments of Medical Imaging and Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada (A.A.D.); Department of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium (A.G.); Department of Neurosurgery and Interventional Neuroradiology, Louisiana State University, LA (B.M., N.A.); Department of Radiology, Brown University, Providence, RI, USA (D.W.); Department of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, California, USA (B.P.); Department of Radiology & Biomedical Imaging, University of California, San Francisco, California, USA (K.N.); Department of Neuroimaging and Neurointervention, Stanford Medical Center, Palo Alto, California, USA (J.J.H., G.W.A.); Department of Radiology, Neuroendovascular Program, University Medical Center Münster, Germany (T.D.F.).
Article Synopsis
UK medical cannabis registry: A clinical outcome analysis of medical cannabis therapy in chronic pain patients with and without co-morbid sleep impairment.
Pain Pract
January 2025
Department of Surgery and Cancer, Medical Cannabis Research Group, Imperial College London, London, UK.
Introduction: Chronic pain (CP) affects 35.0%-51.3% of the UK population, with 67%-88% reporting sleep disturbances.
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