Evidence of Coronavirus (CoV) Pathogenesis and Emerging Pathogen SARS-CoV-2 in the Nervous System: A Review on Neurological Impairments and Manifestations.

The coronavirus disease 2019 (COVID-19) pandemic is an issue of global significance that has taken the lives of many across the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for its pathogenesis. The pulmonary manifestations of COVID-19 have been well described in the literature.

Probing the electronic structure of [Ru(L)] ( = 0, 1+ and 2+) (HL: a tridentate 2-aminophenol derivative) complexes in three ligand redox levels.

Aerobic reaction between [RuII(DMSO)4Cl2], a redox-active 2-aminophenol-based ligand (H2L1: 2-[2-(benzylthio)phenylamino]-4,6-di-tert-butylphenol) and Et3N in MeOH under refluxing conditions afforded a purple complex [Ru(L1)2] (S = 0). Structural analysis reveals that the tridentate ligand coordinates in a mer conformation providing a distorted octahedral RuN2O2S2 coordination. Cyclic voltammetry on 1 in CH2Cl2 reveals the accessability of the monocation, dication and monoanion forms.

Advances in Synthesis, Derivatization and Bioactivity of Isatin: A Review.

Background: Isatin (IST) is a crucial pharmacologically active compound, chemically known as indole- 1H-2,3-dione. Development of different IST based analogues acquired significant awareness because of its pronounced therapeutic importance such as analgesic, anticancer, anti-inflammatory, antitubercular, antimicrobial, antifungal, antiviral (effective against SARS coronavirus 3C protease) and many other activities, and represents an important class of heterocyclic compounds that can be used as a precursor for the synthesis of many useful drugs.

Objective: Previously, many articles were reported on IST synthesis and its different pharmacological activities but herein, we mentioned 59 different synthesis schemes of several IST derivatives/hybrids derived from the substitution of the nitrogen, aromatic ring, the second and third position of IST along with most potent molecule among each of synthesized libraries with their structural activity relationship (SAR).

Unwinding Complexities of Diabetic Alzheimer by Potent Novel Molecules.

Diabetes mellitus is one of the aggressive disorders in global society. No pharmacotherapy is available for permanent diabetes cure, although management is possible with drugs and physical activities. One of the recent complications noticed in type 2 diabetes mellitus includes diabetes-induced Alzheimer.

Design, Synthesis and Studies on Novel Polymeric Prodrugs of Erlotinib for Colon Drug Delivery.

Aims: In the present study, polymer-drug conjugates were synthesized based on azo-bond cleavage drug delivery approach for targeting erlotinib as an anticancer drug specifically to the colon for the proficient treatment of colon cancer.

Background: Colon Cancer (CC) is the third commonly detected tumor worldwide and makes up about 10% of all cases of cancers. Most of the chemotherapeutic drugs available for treating colon cancer are not only toxic to cancerous cells but also to the normal healthy cells.

Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide.

The implimentation of newer technologies in drug delivery system have always been the focus of pharmaceutical scientists with advancement of technologies. In this investigation, a novel controlled-release drug-resin combination device (DRC) was designed using dental resin to control the release of dextromethorphan hydrobromide (DH). The influence of different factors on in-vitro drug release were investigated.

[Cu{(L)˙}] (HL: thioether-appended o-aminophenol ligand) monocation triggers change in donor site from NO to NOS and valence-tautomerism.

Using a potentially tridentate o-aminophenol-based redox-active ligand HL (2-[2-(benzylthio)phenylamino]-4,6-di-tert-butylphenol) in its deprotonated form, [Cu(L)] has been synthesized and crystallized as [Cu(L)]·CHCl (1·CHCl). A cyclic voltammetry experiment (in CHCl; V vs. SCE (saturated calomel electrode)) on 1·CHCl exhibits two oxidative (E = 0.

Phytochemicals in Anticancer Drug Development.

Background: In spite of major technological advances in conventional therapies, cancer continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually emerging as a rich source of effective but safer agents against many life-threatening diseases.

Methods: Various phytochemicals with reported anticancer activity have been simply categorized into major phytoconstituents- alkaloids, polyphenols, saponins, tannins and terpenoids.