559 results match your criteria: "G. Papanikolaou General Hospital[Affiliation]"

Fibrolipomatous hamartomas of the median nerve are rare, benign tumors characterized by the overgrowth of fibro-fatty tissue within the nerve sheath, often leading to nerve compression. This report presents 2 cases: a 33-year-old man with a gradually enlarging wrist mass and a 48-year-old woman, initially diagnosed with De Quervain's tenosynovitis for radial pain, who was found to have an incidental fibrolipomatous hamartoma on MRI. In both cases, MRI played a pivotal role in diagnosis, revealing characteristic features that enabled a definitive, noninvasive diagnosis.

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Article Synopsis
  • Aging affects how driving pressure impacts mortality in patients with ARDS, particularly highlighting that this relationship may be stronger in older individuals, especially those aged 80 and above.!* -
  • A study analyzed data from over 4,500 ARDS patients and found that the difference in driving pressure between those who survived and those who did not varied significantly with age, indicating a critical age-related factor in mortality risk.!* -
  • The results suggest that a personalized approach to mechanical ventilation based on a patient's age could be beneficial for managing ARDS, as certain thresholds for driving pressure may have different implications for older populations.!*
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Presepsin Levels in Infection-Free Subjects with Diabetes Mellitus: An Exploratory Study.

Biomedicines

August 2024

Second Propedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 546 42 Thessaloniki, Greece.

Article Synopsis
  • * A study with 75 individuals highlighted that the duration of diabetes affected presepsin levels, with type 1 diabetes patients showing higher levels compared to type 2 diabetes patients, especially in well-controlled groups.
  • * After considering other factors like age and body mass index, the difference in presepsin levels remained significant, indicating its possible role as a marker for inflammation in diabetes management.
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This case report outlines the diagnostic and therapeutic challenges encountered in a man in his 70s suffering from knee septic arthritis caused by It is the second published case in the literature with osteoarticular infection from and the first one in the last 40 years. Following knee arthroscopy, the patient experienced persistent pain, swelling and discomfort, prompting further investigation. Postoperative knee cultures were negative for infection, but symptoms were not ameliorated.

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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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Two Cases of Testicular Tuberculosis and Review of the Recent Literature.

Int J Mycobacteriol

July 2024

Pulmonary Department, Respiratory Infections Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

In this review, two cases of testicular tuberculosis (TB) are presented, and another 58 cases published in PubMed between January 1, 2012, and July 31, 2023, are reviewed. Testicular TB remains a disease mainly of the developing world, with one notable exception - the infections caused as a result of Bacillus Calmette-Guérin infusion immunotherapy for bladder cancer. Its clinical course is subacute; however, it might get disseminated and become life-threatening; therefore, prompt diagnosis is very important.

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Osteoid osteomas are benign bone tumors characterized by severe localized pain, often challenging the daily lives of young patients. While these tumors are typically solitary, rare cases of multiple osteoid osteomas have been reported. This research paper presents a case series of 2 young patients with multiple osteoid osteomas, highlighting their clinical presentation, diagnostic workup, treatment with cryoablation, and follow-up.

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Echinococcosis presents diverse clinical manifestations, including pulmonary hydatidosis, often asymptomatic but complicated by rare yet dramatic occurrences like hydatoptysis. Here, we report a unique case of recurrent pulmonary and abdominal hydatidosis in a 59-year-old female with bronchial fistulization and hydatoptysis, despite previous surgical interventions. Imaging revealed characteristic features aiding in diagnosis and management decisions.

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Background: The extrafine single inhaler triple therapy (efSITT) containing beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg has proved to be efficacious in patients with chronic obstructive pulmonary disease (COPD) in randomized control trials.

Objective: TRIWIN study evaluated the effectiveness of efSITT delivering beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg in COPD patients previously treated with multiple-inhaler triple therapy (MITT) in a real-world study in Greece.

Design: Prospective, multicenter, observational, non-interventional study was conducted over 24 weeks.

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Small airways disease in chronic obstructive pulmonary disease.

Expert Rev Respir Med

July 2024

Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Introduction: Small airway disease (SAD) represents a common and critical feature of Chronic Obstructive Pulmonary Disease (COPD). Introduced in the '60s, SAD has gradually gained increasing interest as assessment methodologies have improved. Chronic exposure to smoking and noxious particles or gases induces inflammation and remodeling, leading to airway obstruction and SAD, eventually resulting in complete airway loss.

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Article Synopsis
  • Tracheostomy is a procedure often used for patients in ICUs who need long-term ventilation or have airway obstructions, but conflicting studies exist on its timing and benefits.
  • This study analyzed data from 660 critically ill patients over two years, examining various factors like demographics, illness severity, tracheostomy timing, and outcomes.
  • Results indicated that patients who had early tracheostomies experienced significantly shorter durations on mechanical ventilation and in the ICU compared to those with late procedures, along with preferences for specific techniques based on patient conditions.
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Key Clinical Message: In cases adjacent to critical structures, such as the internal carotid artery, surgeons should meticulously explore the feasibility of surgery before declaring the neoplasm unresectable.

Abstract: Salvage treatment for locally recurrent carcinoma of the nasopharynx constitutes a unique challenge. Surgery remains the gold standard treatment modality.

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The future of drug delivery offers immense potential for the creation of nanoplatforms based on nanogels. Nanogels present a significant possibility for pharmaceutical advancements because of their excellent stability and effective drug-loading capability for both hydrophobic and hydrophilic agents. As multifunctional systems, composite nanogels demonstrate the capacity to carry genes, drugs, and diagnostic agents while offering a perfect platform for theranostic multimodal applications.

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Candida auris is an emerging fungal pathogen associated with multi-drug resistance rates and widespread outbreaks in hospitals and healthcare units worldwide. Sequencing studies have revealed that different clonal lineages of the fungus seem to be prevalent among distinct geographical sites. The first case of C.

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  • The Covid-19 pandemic made it hard for hospitals to care for patients with severe lung problems, especially in Intensive Care Units (ICUs).
  • This study looked at how sounds from patients’ lungs could help doctors understand their lung damage and predict how long they would stay in the ICU and their chances of survival.
  • The researchers found that certain lung sounds, like “squawks” and “crackles,” were important because they related to how patients were doing and could help doctors make better decisions about their care.
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Introduction: Anatomical preservation and functional integrity of the facial nerve (FN) are the main concerns of parotid surgery. Even though a variety of anatomical landmarks have been proposed and widely utilized, temporal or permanent postoperative FN palsy is still a significant comorbidity of parotid surgery. Therefore, the literature must fully elucidate the consistency of the anatomical relationship between the FN and the retromandibular vein (RMV).

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Dysphagia is a common symptom with various underlying etiologies, making its management challenging even for experienced physicians. The presence of osteophytes in the cervical spine may often impede swallowing, displace the larynx, and cause a sore throat. We describe a case of an 85-year-old male who presented with a two-year history of progressive dysphagia, exacerbated over the last two months, especially with solid foods and liquids, prompting an ENT evaluation.

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  • The study explored how the KRAS biomarker can predict treatment outcomes for patients with advanced non-small cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs) and chemotherapy.
  • It included 100 male patients, mostly with adenocarcinoma; KRAS G12C mutations were found in 73% of samples, and overall survival was significantly better for patients with negative KRAS results.
  • Findings suggest that KRAS mutations are linked to poorer survival rates in NSCLC patients after immunotherapy, regardless of PDL1 expression levels.
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Sickle cell disease is the most common genetic hemoglobinopathy worldwide, characterized by a single-nucleotide mutation that predisposes to hemoglobin polymerization and erythrocyte sickling in hypoxic states. This report describes a 62-year-old male obese patient with a history of sickle cell disease, who presented with worsening nocturnal pain crises without any apparent triggering factor. A thorough evaluation at the outpatient department revealed obstructive sleep apnea.

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Objective: Transoral robotic surgery total laryngectomy is a promising procedure. We conducted a systematic review to study the indications, surgical techniques and complications of this procedure.

Methods: We followed the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement.

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: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease associated with increased cardiovascular (CV) burden. Besides increased arterial stiffness and subclinical atherosclerosis, microvascular dysfunction is considered an important component in the pathophysiology of CV disease. However, there is a lack of data regarding the effect of multiple target organ damage (TOD) on CV health.

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