3 results match your criteria: "G. Oppenheimer Center for the Neurobiology of Stress and Resilience[Affiliation]"
Genome-Wide DNA Methylation Identifies Potential Disease-Specific Biomarkers and Pathophysiologic Mechanisms in Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Celiac Disease.
Neurogastroenterol Motil
December 2024
G. Oppenheimer Center for the Neurobiology of Stress and Resilience, Los Angeles, California, USA.
Article Synopsis
- The study investigates DNA methylation profiles of irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), celiac disease (CeD), and healthy controls (HC) to develop classifiers that can distinguish these GI disorders.
- Researchers analyzed blood samples from 315 participants and found significant differences in DNA methylation between disorders, especially between IBS & IBD and IBD & CeD.
- The classification models showed promising accuracy (AUC values ranging from 0.73 to 0.80), suggesting that blood-based DNA methylation biomarkers might effectively differentiate between these chronic gastrointestinal conditions.
Negative Events During Adulthood Are Associated With Symptom Severity and Altered Stress Response in Patients With Irritable Bowel Syndrome.
Clin Gastroenterol Hepatol
October 2019
G. Oppenheimer Center for the Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address:
Background & Aims: Irritable bowel syndrome (IBS) is a stress-sensitive disorder associated with dysregulation of the hypothalamic-pituitary-adrenal axis. We studied the cumulative effect of events during adulthood on this pathway in patients with IBS.
Methods: We studied 129 patients with IBS, based on Rome III criteria (mean age 28.
Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study.
PLoS One
April 2019
Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, United States of America.
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has yielded neuroimaging and urinary biomarker findings that highlight unique alterations in brain structure and in urinary proteins related to tissue remodeling and vascular structure in patients with Urological Chronic Pelvic Pain Syndrome (UCPPS). We hypothesized that localized changes in diffusion tensor imaging (DTI) measurements might be associated with corresponding changes in urinary protein levels in UCPPS. To test this hypothesis, we created statistical parameter maps depicting the linear correlation between DTI measurements (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)) and urinary protein quantification (MMP2, MMP9, NGAL, MMP9/NGAL complex, and VEGF) in 30 UCPPS patients from the MAPP Research Network, after accounting for clinical covariates.
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