Intraperitoneal normal saline and bupivacaine infusion for reduction of postoperative pain after laparoscopic cholecystectomy.

After laparoscopic cholecystectomy, CO2 remains within the peritoneal cavity, commonly causing pain. This prospective randomized study was performed to determine the efficacy of intraperitoneal normal saline and bupivacaine infusion on postoperative pain after laparoscopic cholecystectomy. Three hundred patients were randomly assigned to one of six groups of 50 patients each.

Laparoscopic intraperitoneal onlay mesh repair of incisional hernia.

Improvements in laparoscopic techniques and equipment have engendered many new intraabdominal procedures. Laparoscopic hernioplasty was used in 11 patients with 12 incisional abdominal hernias. All repairs were made with an intraperitoneal onlay patch of expanded polytef Gore-Tex DualMesh Biomaterial.

Intraperitoneal normal saline infusion for postoperative pain after laparoscopic cholecystectomy.

After laparoscopic surgery carbon dioxide remains within the peritoneal cavity for a few days, commonly causing pain. This prospective randomized study was performed to determine the efficacy of intraperitoneal infusion of normal saline on postoperative pain after laparoscopic cholecystectomy. Altogether 300 patients were randomly assigned to one of five groups of 60 patients each.

Laparoscopic modified Sugiura procedure: experimental study on the pig.

Background: The Sugiura procedure is an alternative treatment for bleeding gastroesophageal varices. Laparoscopic Sugiura procedure has not previously been described. The aim of this study is to develop a laparoscopic oesophageal transection with an EEA stapler, as well as a complete laparoscopic modified Sugiura procedure.

Modified Sugiura's procedure may improve liver function in portal hypertension.

Background/aims: Sugiura procedure is an alternative in the treatment of the bleeding gastroesophageal varices. The postoperative alterations of CT and biochemical features versus pre-operative levels in patients operated on for haemorrhagic portal hypertension were studied.

Material And Methods: Eight patients with liver cirrhosis and portal hypertension who underwent emergency or elective modified Sugiura's operation, were included in this study.

Low-molecular-weight heparins and Daflon for prevention of postoperative thromboembolism.

The efficacy of low-molecular-weight heparins (LMWH) alone versus a combination of Daflon 500 mg with LMWH in preventing postoperative symptomatic thromboembolism was investigated. A total of 1372 patients aged 40 years or older undergoing major abdominal, pelvic, or abdominal wall surgery were randomized into four groups. Group A (n = 591) received enoxoparin 20 mg or fraxiparin 0.

Perioperative benzimidazole therapy in human hydatid liver disease.

Primary treatment of liver hydatidosis is surgical, but the recurrence rate is about 10%. To minimize the risk of recurrence, 67 consecutive patients with liver hydatidosis were prospectively treated by mebendazole or albendazole for 5 days before surgery. During the operation the viability of the protoscoleces was assessed.

Cholecystectomy and hernioplasty during the same laparoscopic procedure.

Cholelithiasis and inguinal or femoral hernia usually coexist in the same patient. The simultaneous laparoscopic approach to these diseases benefits the patients, who avoid two separate admissions to the hospital, two operations, and twice the cost, recuperation, and potential morbidity and mortality. The authors describe a technique that facilitates cholecystectomy and hernioplasty during the same laparoscopic approach, thus avoiding the use of two separate procedures.

Modified Nissen fundoplication in the treatment of gastroesophageal reflux disease.

Twenty-five consecutive patients underwent a primary modified Nissen fundoplication for gastroesophageal reflux disease. According to this procedure, an increase of the diameter of the gastric wrap to a comfortable passage of the surgeon's index finger between oesophagus and gastric wrap was obtained, while the length of the gastric wrap was 1.0 cm.

Trimetazidine for prevention of hepatic injury induced by ischaemia and reperfusion in rats.

Objective: To assess the effect of trimetazidine (an anti-anginal drug that acts as a scavenger of oxygen free radicals) in the protection of hepatocytes after a 90 minute period of warm ischaemia followed by reperfusion in rats.

Design: Prospective study.

Material: 80 Wistar rats.

Short-term antibiotic prophylaxis in elective colorectal surgery.

In the last 2 years, 50 patients who underwent elective colorectal surgery were prospectively studied about antibiotic prophylaxis. Two groups of 25 patients each were randomly selected. Both received: (a) a colic preparation: hypactic drugs and two enemas during the day before surgery and (b) metronidazole 0.

Prevention of peritoneal adhesions in rats with trimetazidine.

The effect of trimetazidine (an antianginal drug that acts as a scavenger of oxygen radicals) in the prevention of peritoneal adhesions induced by complete vascular obstruction of an ileal segment for 30 minutes followed by reperfusion was investigated in rats. Group A (n = 20) acted as controls. Group B (n = 20) received trimetazidine intravenously in a dose of 2.

Pituitary adrenal responsiveness to corticotropin-releasing hormone in chronic uremic patients.

We investigated the effect of exogenous ovine corticotropin-releasing hormone (oCRH) on plasma levels of adrenocorticotropic hormone (ACTH) and cortisol in 24 chronic renal failure patients: 8 nondialysis (NDCRF), 8 on hemodialysis (HD), and 8 on continuous ambulatory peritoneal dialysis (CAPD). In all groups the acute administration of oCRH caused a further increase (less pronounced in NDCRF patients) in the already elevated levels of cortisol. Following oCRH administration, plasma ACTH rose significantly in CAPD patients, but there was a blunted response of the hormone in the NDCRF and HD groups.

Survival after severe iatrogenic hypernatremia.

The case of a 24-year-old woman who survived without subsequent neurological damage after severe iatrogenic hypernatremia is presented. This previously healthy woman who had given birth with an uncomplicated delivery developed hypernatremia (serum sodium, 178 mmol/L) after erroneous infusion of hypertonic sodium solution.

The role of oxygen-derived free radicals in peritoneal adhesion formation induced by ileal ischaemia/reperfusion.

The effectiveness of superoxide dismutase (SOD), catalase (CAT), dimethyl sulphoxide (DMSO) and allopurinol in prevention of peritoneal adhesion formation induced by complete vascular obstruction and reperfusion of an ileal segment was investigated in rats. The ischaemic period was 30 min. Group A (n = 20) were controls, group B (n = 15) received SOD 15,000 U/kg i.

Ovine corticotropin-releasing hormone stimulation test in patients with chronic renal failure: pharmacokinetic properties, and plasma adrenocorticotropic hormone and serum cortisol responses.

The data on the status of the hypothalamic-pituitary-adrenal (HPA) axis in haemodialysis (HD) patients are conflicting. Moreover, a state reminiscent of Cushing's syndrome has been reported in this group of patients. Corticotropin-releasing hormone (CRH), that is produced by the hypothalamus and modulates the secretion of adrenocorticotropic hormone (ACTH), has been shown to be useful as a provocative test of the HPA axis.