Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.

In multiple sclerosis (MS), Th17 cells are critical drivers of autoimmune central nervous system (CNS) inflammation and demyelination. Th17 cells exhibit functional heterogeneity fostering both pathogenic and nonpathogenic, tissue-protective functions. Still, the factors that control Th17 pathogenicity remain incompletely defined.

Ruptured tubo-ovarian abscess as a complication of IVF treatment: clinical, ultrasonographic and histopathologic findings. A case report.

Tuboovarian abscess is a rare complication of IVF treatment, which can be lethal on rupture. Hereby, we present a case of a ruptured tubo-ovarian abscess, following transvaginal ultrasound-guided oocyte retrieval for IVF and transcervical embryo trasfer in a 38-year-old white female patient with five years of primary infertility who underwent aspiration of bilateral hydrosalpinges at the time of oocyte retrieval. This case suggests that the reactivation of latent pelvic infection due to a previous pelvic inflammatory disease (PID) was the possible route of infection after transvaginal ultrasound-directed follicle aspiration--transcervical embryo transfer.

Torsion of a non-gravid leiomyomatous uterus in a patient with myotonic dystrophy complaining of acute urinary retention: anaesthetic management for total abdominal hysterectomy.

Torsion of a pregnant uterus is rare, but torsion of a non-pregnant uterus is extremely rare. Abdominal pain is the major symptom. Other symptoms include vaginal bleeding, urinary tract symptoms and gastro-intestinal manifestations.

Clinical considerations and sonographic findings of a large nonpedunculated primary cervical leiomyoma complicated by heavy vaginal haemorrhage: a case report and review of the literature.

Leiomyomas of the uterine cervix are uncommon. Cervical leiomyomas in non-pregnant women rarely are of clinical significance and their complications include pressure effects on the bladder or urethra, degenerative phenomema and menorrhagia. We present a case of 46-year-old female, gravida 2, para 1 who was presented in the gynaecological emergency room with the chief complaint of profound vaginal bleeding over the previous three weeks with recent passage of clots.

Uncemented total hip arthroplasty in the elderly.

Between January 1991 and December 1994, 132 uncemented total hip arthroplasties (THA) were performed on 125 patients over 65 years of age; of which 102 arthroplasties, performed in 90 patients, were followed for at least 4 years. One revision was necessary following fracture of an acetabular component secondary to trauma. The post-operative Harris hip score (HHS) ranged from 87 to 99.