Development and validation of a prediction model for coronary heart disease risk in depressed patients aged 20 years and older using machine learning algorithms.

Background: Depression is being increasingly acknowledged as an important risk factor contributing to coronary heart disease (CHD). Currently, there is no predictive model specifically designed to evaluate the risk of coronary heart disease among individuals with depression. We aim to develop a machine learning (ML) model that will analyze risk factors and forecast the probability of coronary heart disease in individuals suffering from depression.

Genome-wide analysis of sugar transporter gene family in and , expression profiling and identification of transcription factors.

Sugar, the primary product of photosynthesis, is a vital requirement for cell activities. Allocation of sugar from source to sink tissues is facilitated by sugar transporters (ST). These STs belong to the Major Facilitator Superfamily (MFS), the largest family of STs in plants.

Different smoking processes with the special fuel rods: Impart a smoky aroma to Souchong black tea.

The smoky scent is the most distinctive feature for Souchong black tea. To reduce the dependence on pinewood in the smoking process of Souchong black tea, it is crucial to find an effective alternative smoking material. Five black tea samples were prepared via using specially designed fuel rods as the smoking material in this study.

Fat mass and obesity-associated protein expression in colorectal cancer and its influence on the biological behaviour of colorectal cancer cells.

Fat mass and obesity-associated protein (FTO) was the earliest discovered m6A RNA demethylase. Previous studies have indicated that m6A modifications significantly influence the development, progression, and prognosis of various cancers. This study aimed to explore the role of FTO overexpression in colorectal cancer development, as well as its biological functions.

Aroma analysis and biomarker screening of 27 tea cultivars based on four leaf color types.

Green is no longer the only color used to describe tea leaves. As tea plants with different leaf colors-white, yellow, and purple-yield significant economic benefits, scholars are growing increasingly curious about whether these differently colored leaves possess unique aromatic characteristics. Headspace solid-phase microextraction (HS-SPME) combined with GC-MS was used to analyze the volatile metabolites of buds and leaves from 7 white-leaf tea plants, 9 yellow-leaf tea plants, 4 purple-leaf tea plants, and 7 normal (green) tea plants.

ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2.

Background: Lung cancer, particularly non-small cell lung cancer (NSCLC), has high recurrence rates and remains a leading cause of cancer-related death, despite recent advances in its treatment. Emerging therapies, such as chimeric antigen receptor (CAR)-T cell therapy, have shown promise but face significant challenges in targeting solid tumors. This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy.

Evaluating the impact of ESICM 2023 guidelines and the new global definition of ARDS on clinical outcomes: insights from MIMIC-IV cohort data.

Background: In 2023, the European Society of Intensive Care Medicine (ESICM) recommended updated criteria for acute respiratory distress syndrome (ARDS). In 2024, Matthay et al. updated the global ARDS definition in AJRCCM, titled "A New Global Definition of Acute Respiratory Distress Syndrome.

Deep learning model targeting cancer surrounding tissues for accurate cancer diagnosis based on histopathological images.

Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. The remodeled microenvironment and field cancerization may enable the cancer-specific features in the image of non-cancer regions surrounding cancer, which may provide additional information not available in the cancer region to improve cancer diagnosis.

Risk factors and prognosis analysis of dysphagia after occipitocervical fusion surgery: a retrospective study of 43 cases.

Objectives: To analyze the risk factors for developing dysphagia after occipitocervical fusion (OCF) and investigate possible mechanisms and prognosis.

Methods: The case data of 43 patients who underwent OCF were retrospectively reviewed. Patients were divided into group A (dysphagia group) and group B (non-dysphagia group) based on Bazaz scoring criteria.

Associations between CAG repeat size, brain and spinal cord volume loss, and motor symptoms in spinocerebellar ataxia type 3: a cohort study.

Background: Spinocerebellar ataxia type 3 (SCA3) is a hereditary disease caused by abnormally expanded CAG repeats in the ATXN3 gene. The study aimed to identify potential biomarkers for assessing therapeutic efficacy by investigating the associations between expanded CAG repeat size, brain and spinal cord volume loss, and motor functions in patients with SCA3.

Methods: In this prospective, cross-observational study, we analyzed 3D T1-weighted MRIs from 92 patients with SCA3 and 42 healthy controls using voxel-based morphometry and region of interest approaches.

Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at an advanced stage due to the lack of non-invasive early detection tools, which significantly impacts patient prognosis. Given that glycosylation alterations especially high sialylation and fucosylation, frequently occur during cellular malignant transformation, but their roles are not elucidated. We examined alterations in disease-specific glycosylated extracellular vesicles (EVs)-derived miRNAs in the serum of ESCC patients, evaluating their utility as diagnostic biomarkers.

Surgical treatment of anomalous aortic origin of the coronary artery in paediatric patients: a Chinese single-center experience.

Purpose: An anomalous aortic origin of the coronary artery (AAOCA) is a rare congenital heart disease. Some high-risk anatomical structures are at risk of inducing cardiogenic shock or even sudden death. This article summarizes our surgical experience with AAOCA in paediatric patients.

Application of metagenomic next-generation sequencing (mNGS) to describe the microbial characteristics of diabetic foot ulcers at a tertiary medical center in South China.

Background: Diabetic foot ulcers (DFUs) are characterized by dynamic wound microbiome, the timely and accurate identification of pathogens in the clinic is required to initiate precise and individualized treatment. Metagenomic next-generation sequencing (mNGS) has been a useful supplement to routine culture method for the etiological diagnosis of DFUs. In this study, we utilized a routine culture method and mNGS to analyze the same DFU wound samples and the results were compared.

Improved diagnosis of small cervical lymph node metastasis using postvascular phase perfluorobutane CEUS in cancer patients.

Background: Accurate identification of small metastatic lymph nodes (LNs) remains a significant challenge with conventional ultrasound (US) due to its limitations in sensitivity for smaller LNs. The use of contrast-enhanced ultrasound (CEUS), especially with perfluorobutane in the postvascular phase of CEUS, may improve the diagnosis of metastatic LNs in cancer patients. We sought to investigate the diagnostic accuracy of the postvascular phase of CEUS with perfluorobutane in identifying suspected small cervical LNs in cancer patients.

Construction and evaluation of a triage assessment model for patients with acute non-traumatic chest pain: mixed retrospective and prospective observational study.

Background: Acute non-traumatic chest pain is one of the common complaints in the emergency department and is closely associated with fatal disease. Triage assessment urgently requires the use of simple, rapid tools to screen patients with chest pain for high-risk condition to improve patient outcomes.

Methods: After data preprocessing and feature selection, univariate and multiple logistic regression analyses were performed to identify potential predictors associated with acute non-traumatic chest pain.

Masquelet technique combined with concentrated growth factors for the reconstruction of rabbit mandibular marginal bone defect.

Objective: Both the Masquelet technique (MT) and concentrated growth factors (CGF) reduce early graft loss and improve bone regeneration. This study aims to explore the efficacy of combining MT with CGF for mandibular defect repair by characterizing the induced membrane and assessing in vivo osteogenesis.

Materials And Methods: Three experimental groups were compared: negative control (NC), MT, and Masquelet combined with CGF (MTC).

Incidence trends and prognostic factors in head and neck MALT lymphoma.

Primary head and neck mucosa-associated lymphoid tissue lymphoma (HN-MALT) is a rare lymphoma with unknown incidence and prognosis. We allocated HN-MALT data from the Self-Surveillance, Epidemiology, and End Results database (2000-2021) into training and validation cohorts at a 7:3 ratio. A joinpoint regression analysis was used to examine sex-specific and age-group morbidities, and independent prognostic factors were identified through multivariate Cox analysis to construct a nomogram prediction model and verify the accuracy of prediction.

Colonoscopic administration of probiotics to treat irritable bowel syndrome with predominant diarrhea: a randomized placebo-controlled clinical trial.

Background: To investigate the effects of colonoscopic administration of probiotics on patients with irritable bowel syndrome with predominant diarrhea (IBS-D) by a single-center, randomized-controlled trial.

Methods: Consecutive outpatients at the First Affiliated Hospital of Fujian Medical University who met the Rome IV diagnostic criteria for IBS-D (n = 22) and healthy subjects (n = 10) from January 2017 to January 2018 were enrolled. IBS-D patients were randomly divided into either the probiotics or the placebo group.

A Markov decision optimization of medical service resources for two-class patient queues in emergency departments via particle swarm optimization algorithm.

In the modern healthcare system, the rational allocation of emergency department (ED) resources is crucial for enhancing emergency response efficiency, ensuring patient safety, and improving the quality of medical services. This paper focuses on the issue of ED resource allocation and designs a priority sorting system for ED patients. The system classifies patients into two queues: urgent and routine.

Beyond Polymerization: In Situ Coupled Fluorination Enables More Stable Interfaces for Solid-State Lithium Batteries.

In situ polymerization strategies hold great promise for enhancing the physical interfacial stability in solid-state batteries, yet (electro)chemical degradation of polymerized interfaces, especially at high voltages, remains a critical challenge. Herein, we find interphase engineering is crucial for the polymerization process and polymer stability and pioneer an in situ polymerization-fluorination (Poly-FR) strategy to create durable interfaces with excellent physical and (electro)chemical stabilities, achieved by designing a bifunctional initiator for both polymerization and on-surface lithium donor reactions. The integrated in situ fluorination converts LiCO impurities on LiNiCoMnO (NCM811) surfaces into LiF-rich interphases, effectively inhibiting the aggressive (de)lithiation intermediates and protecting the interface from underlying chemical degradation, thereby surpassing the stability limitations of polymerization alone.

Poly(lactic acid)-based materials with enhanced gas permeability for modified atmosphere packaging of Chinese bayberry.

Biodegradable plastics are increasingly utilized in packaging, driven by green chemistry and environmental responsibility. Among them, poly(L-lactic acid) (PLLA) stands out due to its biodegradability and biocompatibility. However, its limited gas permeability and selectivity hinder its application in produce preservation.

Percutaneous Magnetic Resonance Imaging-Guided Microwave Ablation for Patients with Cirrhosis Complicated by Small Hepatocellular Carcinoma.

Objective: To assess the technical effectiveness and therapeutic outcomes of percutaneous magnetic resonance (MR)-guided microwave ablation (MWA) in the treatment of patients with cirrhosis complicated by small hepatocellular carcinoma (HCC).

Materials And Methods: A single center retrospective analysis of consecutive cases involving 1.5T MR-guided MWA for hepatocellular carcinoma was performed.

Can green finance exorcize the resource curse in China's resource-based cities? A geographically and temporally weighted regression (GTWR) analysis.

Resource-dependent regions often face the challenge of the resource curse, which hinders sustainable development. This study investigates how green finance can address this issue, using panel data from 115 resource-based cities in China and employing a two-way fixed effects model and a Geographically and Temporally Weighted Regression (GTWR) model. The findings reveal that: First, resource-based cities in China exhibit the resource curse, characterized by significant spatiotemporal non-stationarity.

Mogroside V ameliorates astrocyte inflammation induced by cerebral ischemia through suppressing TLR4/TRADD pathway.

Inflammation and oxidative stress are pivotal factors in the onset and progression of secondary injury following cerebral ischemia-reperfusion (I/R). Mogroside V (MV), a primary active compound of Siraitia grosvenorii, exhibits significant anti-inflammatory and antioxidant properties. However, its specific effects in cerebral ischemia remain unclear.

Regulating gypsum scaling-induced wetting in membrane distillation by heterogeneous crystallization: Role of filter media.

Mineral scaling and scaling-induced wetting are critical issues in membrane distillation (MD) during treatment of saline wastewaters. Gypsum scaling and scaling-induced wetting in MD were successfully regulated by heterogeneous crystallization with in-line granular filtration in this study. Stable water recovery increased from 32.