An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation.

Myocarditis, a leading cause of sudden cardiac death and heart transplantation, poses significant treatment challenges. The study of clinical samples from myocarditis patients reveals a correlation between the pathogenesis of myocarditis and cardiomyocyte mitochondrial DNA (mtDNA). During inflammation, the concentration of mtDNA in cardiomyocytes increases.

Prevalence and Prognostic Significance of Malnutrition Risk in Patients With Valvular Heart Disease.

Background: Previous studies on the prevalence and prognosis of nutritional status in valvular heart disease (VHD) were primarily limited to aortic stenosis. The nutritional status of other types of VHDs remained an underexplored area.

Objectives: This study aimed to evaluate the prevalence of malnutrition risk in different types of VHD and investigate the association between malnutrition risk and adverse clinical events.

Causal relationships between uremic metabolites or toxins and heart failure: Univariate and multivariate Mendelian randomization.

Studies have shown that uremia, renal failure and heart failure (HF) are closely related. However, whether this association reflects a causal effect is still unclear. The aim of this study was to evaluate the causal effect of uremic metabolites or toxins on HF.

Causal associations between telomere length and pulmonary arterial hypertension: A two-sample Mendelian randomization study.

Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by elevated pulmonary artery pressure, leading to right heart failure, and mortality. The role of telomere length, a marker of biological aging, in PAH remains unclear. We utilized summary-level data from genome-wide association studies for various measures of telomere length and PAH.

Rapid Preparation of Collagen/Red Blood Cell Membrane Tubes for Stenosis-Free Vascular Regeneration.

Extracellular matrix (ECM)-based small-diameter vascular grafts (SDVGs, inner diameter (ID) < 6 mm) hold great promise for clinical applications. However, existing ECM-based SDVGs suffer from limited donor availability, complex purification, high cost, and insufficient mechanical properties. SDVGs with ECM-like structure and function, and good mechanical properties were rapidly prepared by optimizing common materials and preparation, which can improve their clinical prospects.

Association Between Short-Term Exposure to Ambient PM and Its Components with Hospital Admissions for Patients with Coronary Heart Disease and Comorbid Diabetes Mellitus in Beijing, China.

Existing researches had primarily investigated the associations between various air pollutants and the risk of coronary heart disease (CHD) or diabetes mellitus (DM) separately. However, the significance and effects of PM and its components in patients with CHD and comorbid DM (CHD-DM) remain unclear. Patient data was sourced from the Beijing Municipal Health Commission Information Centre between January 1, 2014, and December 31, 2018.

Numerical simulation of fluid-structure interaction analysis for the performance of leaflet reimplantation with different types of artificial graft.

Background And Objective: In clinical practice, valve-sparing aortic root replacement surgery primarily addresses left ventricular dysfunction in patients due to severe aortic regurgitation, but there is controversy regarding the choice of surgical technique. In order to investigate which type of valve-sparing aortic root replacement surgeries can achieve better blood flow conditions, this study examines the impact of changes in the geometric morphology of the aortic root on the hemodynamic environment through numerical simulation.

Methods: An idealized model of the aortic root was established based on data obtained from clinical measurements, including using the model of the aortic root without significant lesions as the control group (Model C), while using surgical models of leaflet reimplantation with tubular graft (Model T), leaflet reimplantation with Valsalva graft (Model V), and the Florida sleeve procedure (Model F) as the experimental groups.

Myocardial Abnormalities Across the AHA/ACC Stages of Heart Failure in Patients With Diabetes.

Background: Cardiac magnetic resonance imaging (CMR) could serve as a robust tool for comprehensive evaluation of early changes across heart failure (HF) stages classified by the American Heart Association/American College of Cardiology guideline in diabetes mellitus (DM).

Objectives: The authors aimed to explore phenotypic imaging features characterizing DM participants at different HF stages by CMR.

Methods: DM participants with preserved ejection fraction who underwent CMR examination between January 2020 and December 2021 were evaluated.

Catheter Ablation for Ventricular Tachycardia in Patients With Biopsy-Proven Myocarditis.

Background: Catheter ablation (CA) is increasingly recognized as an effective treatment for ventricular tachycardia (VT) in myocarditis patients, although current evidence is based on less robust data.

Objectives: The purpose of this study was to confirm CA's efficacy in reducing VT recurrence and to identify arrhythmic risk factors in biopsy-proven myocarditis patients.

Methods: In this dual-center, retrospective study, we included 50 patients with biopsy-proven myocarditis and VT.

Bibliometric analysis of levosimendan.

Background: Levosimendan (LEVO), a calcium sensitizer and adenosine triphosphate-dependent potassium channel opener, has been widely used for decades in medical and surgical patients for advanced heart failure (HF), right ventricular failure, cardiogenic shock, takotsubo cardiomyopathy, pulmonary hypertension, and so on. Currently, as the limited scope and lack of comprehensive data in current LEVO publications, there is an increasing obstacle to conducting new studies that require integrated information and quantifiable results. Thus, the current study was performed to identify the research trends and hot spots in LEVO-related publications using bibliometric software.

Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels.

Decellularized artificial blood vessels prepared using physical and chemical methods often exhibit limitations, including poor mechanical performance, susceptibility to inflammation and calcification, and reduced patency. Cross-linking techniques can enhance the stiffness, as well as anti-inflammatory and anti-calcification properties of decellularized vessels. However, conventional cross-linking methods fail to effectively alleviate residual stress post-decellularization, which significantly impacts the patency and vascular remodeling following the implantation of artificial vessels.

Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.

Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel.

Surgical techniques and prognostic nomogram for patients with supravalvular aortic stenosis.

Background: An effective prognostic nomogram to predict the prognosis for supravalvular aortic stenosis (SVAS) patients is lacking.

Methods: A multi-center retrospective study of consecutive SVAS patients with surgery between 2002 and 2020 was conducted. Patients underwent McGoon repairs, Doty repairs, and other repairs.

MAFLD as a predictor of adverse cardiovascular events among CHD patients with LDL-C<1.8 mmol/L.

Background And Aims: Patients receiving statin therapy still suffer from adverse cardiovascular events. Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is a newly proposed concept that shares common metabolic risk factors with cardiovascular disease. This study aimed to investigate the association between MAFLD and adverse cardiovascular outcomes in coronary heart disease (CHD) patients with LDL-C<1.

The association of the triglyceride-glucose index with the risk of atrial fibrillation: Analysis of the UK Biobank.

Background And Aims: The relationship between the triglyceride-glucose (TyG) index and the incidence of atrial fibrillation (AF) remains insufficiently explored. This investigation aims to elucidate the association between the TyG index and the long-term risk of developing AF.

Methods And Results: This cohort study analyzed data from 409,705 participants sourced from the UK Biobank database.

Clinical implications of longitudinally assessed uric acid in heart failure.

Background And Aims: Numerous studies have evaluated the association between baseline uric acid (UA) and heart failure (HF) outcomes. The impact of longitudinal UA on HF survival remains unknown. We aim to investigate the association between different parameterizations of longitudinal UA measurements and survival outcomes in HF patients.

Numerical simulation on the effect of impeller radial gap on hemodynamics and hemocompatibility of a centrifugal blood pump.

Impeller radial gap is one of important parts within a blood pump, which may affect the hemodynamics and hemocompatibility. In this study, computational fluid dynamics method was performed to evaluate the impact of radial gap sizes. The volume of scalar shear stress decreased with radial gap sizes increasing.

Associations of the hs-CRP/HDL-C ratio with cardiovascular disease among US adults: Evidence from NHANES 2015-2018.

Background And Aims: Inflammation, lipid signaling, and their interplay are involved in the pathogenesis and development of cardiovascular diseases (CVDs), while the relationships of composite indices combining inflammation and lipids with CVD remained inexplicit.

Methods And Results: Our study enrolled 8581 adults from the National Health and Nutrition Examination Survey 2015-2018. Logistic regression model was applied to assess the associations of high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio with CVD prevalence.

Evaluation of endothelialization of an occluder device with cardiac computed tomography and assessment of the pathological validation.

Background: Assessing the endothelialization of occlusive devices noninvasively remains a challenge. Cardiac computed tomography angiography (CTA) can be employed to evaluate device endothelialization based on contrast uptake within the occluder.

Objective: This study examined device endothelialization using cardiac CTA and investigated the pathological associations.