Prior Use of Medication for Primary Prevention in Patients with Coronary Syndrome.

Cardiovascular disease, especially coronary disease, represents one of the main causes of morbidity and mortality. To determine the drug prescription profile for primary cardiovascular prevention prior to a first acute coronary syndrome event. Cross-sectional study.

Functional Genomics of Epileptogenesis in Animal Models and Humans.

It has been estimated that epilepsies are among the top five neurological diseases with the highest burden of disease. In recent years, genome-wide expression studies (GWES) have been carried out in experimental models of epilepsy and in samples from human patients. In this study, I carried out meta-analyses and analyses of convergence for available GWES for epileptogenesis in humans and in mouse, rat, zebrafish and fruit fly models.

Recommendations for working from home during the COVID-19 pandemic (and beyond).

Background: There is a growing trend around the globe for having more people working from home, particularly in the current COVID-19 pandemic. Although it is widely implemented in a number of countries and types of companies, it has shown to have multiple challenges.

Methods: In this article, we provide several recommendations on how to work from home, incorporating information from several publications.

Growth Plate Pathology in the Mucopolysaccharidosis Type VI Rat Model-An Experimental and Computational Approach.

Background: Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by impaired function or absence of lysosomal enzymes involved in degradation of glycosaminoglycans. Clinically, MPS are skeletal dysplasias, characterized by cartilage abnormalities and disturbances in the process of endochondral ossification. Histologic abnormalities of growth cartilage have been reported at advanced stages of the disease, but information regarding growth plate pathology progression either in humans or in animal models, as well as its pathophysiology, is limited.

Integrative In Silico Analysis of Genome-Wide DNA Methylation Profiles in Schizophrenia.

Schizophrenia (SZ) is a complex and severe psychiatric disorder, which has a global lifetime prevalence of 0.4% and a heritability of around 0.81.

Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid - Gelatin injectable hydrogels.

Electrical stimulation (ES) has provided enhanced chondrogenesis of mesenchymal stem cells (MSCs) cultured in micro-mass without the addition of exogenous growth factors. In this study, we demonstrate for the first time that ES of MSCs encapsulated in an injectable hyaluronic acid (HA) - gelatin (GEL) mixture enhances the chondrogenic potential of the hydrogel. Samples were stimulated for 21 days with 10 mV/cm at 60 kHz, applied for 30 min every 6 h a day.

Relative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysis.

The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to provide the threshold of relative HGS from which the adverse effect could be improved or worsened. A total of 4169 participants (69.

Normal-Weight Obesity Is Associated with Increased Cardiometabolic Risk in Young Adults.

Normal-weight obesity (NWO) has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in early adulthood. The aim of this study was to investigate the associations between NWO and cardiometabolic risk factors in a large population of Colombian young adults.

Normative Values for the Short Physical Performance Battery (SPPB) and Their Association With Anthropometric Variables in Older Colombian Adults. The SABE Study, 2015.

The short physical performance battery (SPPB) is a physical performance test of lower extremity function designed for non-disabled older adults. We aimed to establish reference values for community-dwelling Colombian adults aged 60 years or older in terms of (1) the total score; (2) the three subtest scores (walking speed, standing balance performance, and five times sit-to-stand test); and (3) the time to complete the five times sit-to-stand test, s and the walking speed test. Additionally, we sought to explore how much of the variance in the SPPB subtest scores could be explained by anthropometric variables (age, body mass, height, body mass index, and calf circumference).

A functional SNP in the synaptic gene is associated with impulsivity in a Colombian sample.

The aim of the current study was to test the hypothesis that a functional polymorphism in the synaptosome associated protein 25 () gene could be associated with impulsivity scores in a sample of young Colombian subjects. Impulsivity has been postulated as an endophenotype for several psychiatric disorders of high epidemiological relevance. There is a need for the study of additional candidate genes for impulsivity.

Coping Strategies in Male Patients under Treatment for Substance Use Disorders and/or Severe Mental Illness: Influence in Clinical Course at One-Year Follow-Up.

Coping strategies have an impact on substance use disorders (SUD), relapses, and clinical variables, but knowledge on this area is scarce. We explored the coping strategies used during treatment in patients with dual diagnosis (DD), SUD, and severe mental illness (SMI), and the relation with clinical course and relapses at one-year follow-up. A sample of 223 patients was divided into three groups depending on diagnosis: DD ( = 80; SUD with comorbid schizophrenia or major depressive disorder), SUD only ( = 80), and SMI only ( = 63; schizophrenia or major depressive disorder).

In Vitro Evaluation of the Effect of Stimulation with Magnetic Fields on Chondrocytes.

Magnetic fields (MFs) have been used as an external stimulus to increase cell proliferation in chondrocytes and extracellular matrix (ECM) synthesis of articular cartilage. However, previously published studies have not shown that MFs are homogeneous through cell culture systems. In addition, variables such as stimulation times and MF intensities have not been standardized to obtain the best cellular proliferative rate or an increase in molecular synthesis of ECM.

Impact of smoking and physical inactivity on self-rated health in women in Colombia.

The aim of this study was to assess the association between poor and fair self-rested health, smoking, and leisure-time physical inactivity in Colombian women. A cross-sectional study using the data from the 2010 Colombian National Demographics and Health (ENDS) and Nutritional Situation (ENSIN) Surveys was conducted. Multivariate logistic analysis for self-perceived health status in 12,431 women aged 13-49 years old and 8224 women aged 18-64 years old were performed.

Association between the time spent watching television and the sociodemographic characteristics with the presence of overweight and obesity in Colombian adolescents (secondary analysis of the ENSIN 2010).

Objective: To determine the association between the time spent watching television and the sociodemographic characteristics with the presence of overweight and obesity in Colombian adolescents.

Materials And Methods: Secondary analysis of the information obtained in the National Survey of the Nutritional Situation 2010 of Colombia, in a probabilistic sample of 18177 adolescents with an age range between 13 and 17 years. The time spent watching television and / or videogames and sociodemographic factors was determined.

[Prevalence and sociodemographic factors associated with iron deficiency anemia in pregnant women of Colombia (secondary analysis of the ENSIN 2010)].

Objective: iron deficiency anemia is associated with adverse results for health and it is highly prevalent worldwide. The current study evaluated the prevalence and the sociodemographic factors associated with iron deficiency anemia in a sample of Colombian pregnant women. Materials and methods: the secondary analysis for the obtained information at the National Nutrition Survey (ENSIN) 2010 of Colombia in a probabilistic sample of 1,385 pregnant women between 13 and 49 years old.

Health-related quality of life of patients with rotator cuff injuries, Cofee Triangle, Colombia, 2013.

Objective: To determine the quality of life related to health and its related factors in patients diagnosed with rotator cuff lesions in the Municipality of Pereira, Colombia, 2013.

Methods: Cross-sectional study. Simple random sampling of 239 patients over 18 years of age attended at five health care institutions in the urban area of Pereira.

Characterization of Eyeball Loss in Four Cities of Colombia.

Purpose: Describe the socio-demographic characteristics of anophthalmic patients examined at specialized centers of four cities in Colombia to know the different causes of eyeball loss.

Method: A transversal retrospective study was done of 511 medical records from the specialized practices of four cities in Colombia. Socio-demographic data of patients who were seen between January 2011 and December 2013 were compiled.

Effectiveness and clinical inertia in patients with antidiabetic therapy.

Aims: To establish the effectiveness of antidiabetic therapy and the frequency of clinical inertia in the management of type 2 diabetes mellitus in Colombia.

Methods: A cross-sectional study with follow-up of patients who had been treated for at least 1 year and were receiving medical consultation for antidiabetic treatment. Effectiveness was established when haemoglobin-A1c levels were <7% and when clinical inertia was reached, which was defined as no therapeutic modifications despite not achieving management controls.

[Family vulnerability index in the municipality of Pasto, Colombia, 2012].

This study's objective was to measure the vulnerability index of families in the municipality of Pasto, Colombia. In a sample of 270 families of all socioeconomic strata (239 urban and 31 rural), a confidential survey was conducted using the vulnerability index, consisting of five dimensions: demographic, social, economic, environmental, and geography, forecasting, and prevention. The families in strata 1 and 2 and the houses in the center, west, northwest, and northeast of the urban area showed high vulnerability, even higher than those in rural areas.

[Factors related to treatment adherence in patients with tuberculosis in Pereira, Colombia, 2012-2013].

Introduction: According to the World Health Organization, the adherence to the tuberculosis treatment is the extent to which a patient's medication taking coincides with the prescribed treatment. The sum of cured patients and those who have completed treatment (directly observed therapy strategy, DOTS) are pragmatic indicators of the adherence. The patients who do not complete treatment correspond to non-adherents.

[Inequalities in mortality by cardiovascular diseases in the Colombian Coffee Growing Region, 2009-2011].

Introduction: The impact of mortality from cardiovascular diseases requires the measurement of the relationship between the local socioeconomic conditions and these death causes.

Objective: To determine the inequality in mortality from cardiovascular diseases in the municipalities of the Colombian Coffee Growing Region (2009-2011).

Materials And Methods: We conducted an ecological study to compare the mortality from cardiovascular diseases (hypertensive, ischemic, cerebrovascular) in municipalities and their economic situation.