Safety of airway clearance combined with bronchodilator and hypertonic saline in non-hospitalized infants with acute bronchiolitis.

Background: Acute viral bronchiolitis (AVB) is associated with significant morbidity and no study has addressed the safety of airway clearance techniques (ACT) for non-hospitalized infants. This study aimed to evaluate the safety of the use of ACT combined with bronchodilator and hypertonic saline in non-hospitalized children with the first episode of AVB.

Methods: A quasi-experimental study of infants aged 2-12 months, with a clinical diagnosis of AVB (mild to moderate), was performed.

Menigococcal endophthalmitis: A rare cause of endogenous endophthalmitis.

Neisseria meningitidis is a rare but severe cause of endogenous endophthalmitis. We report a case of a 46-year-old woman who presented an endophthalmitis secondary to an infection by Neisseria meningitidis that caused with meningitis. She was treated with corticosteroids and systemic and topical antimicrobials, but she presented loss of visual acuity as a consequence.

GLP1 Receptor Agonist and SGLT2 Inhibitor Combination: An Effective Approach in Real-world Clinical Practice.

Purpose: The aim of this study was to evaluate the effectiveness and safety of combination therapy with a sodium-glucose cotransporter-2 (SGLT2) inhibitor and a glucagon-like peptide-1 receptor agonist (GLP1RA) in patients with inadequately controlled type 2 diabetes.

Methods: A retrospective search of electronic prescriptions of patients undergoing GLP1RA and SGLT2 inhibitor combination therapy was conducted. Once the patients had been identified, demographic data, blood and urine analyses (glycosylated hemoglobin [HbA], glucose, renal function, albuminuria, lipid profile, liver enzymes, and uric acid), physical examination (weight, body mass index, and blood pressure), and adverse effects were obtained from their electronic clinical records according to each of the following 3 periods: before the initiation of the combination, the first visit after initiation, and the last available visit.

Systemic phenotype of sarcoidosis associated with radiological stages. Analysis of 1230 patients.

Background: To analyze the association between Scadding radiological stages of sarcoidosis at diagnosis and the disease phenotype (epidemiology, clinical presentation and extrathoracic involvement) in one of the largest cohorts of patients with sarcoidosis reported from southern Europe.

Methods: The SARCOGEAS-Study Group includes a multicenter database of consecutive patients diagnosed with sarcoidosis according to the WASOG 1999 criteria. Extrathoracic disease at diagnosis was defined according to the 2014 instrument and the clusters proposed by Schupp et al.

Clinical factors associated with pulmonary aspergillosis in patients with chronic obstructive pulmonary disease.

Objective: To explore the clinical and epidemiological characteristics of chronic obstructive pulmonary disease (COPD) patients with Aspergillus spp. isolation from respiratory samples, and to identify which factors may help us to distinguish between colonisation and infection.

Methods: A retrospective cohort study was performed.

Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain.

Actinic cheilitis is thought to be a premalignant lesion or a superficial squamous cell carcinoma. The prevalence of actinic cheilitis in Europe is unknown. The aim of this study was to determine the prevalence of actinic cheilitis in the Galicia region (north-west Spain).

Unusual Interface Dermatoses Distributed Along Blaschko's Lines in Adult Patients.

Linear dermatoses are unusual entities whose distribution reflects cutaneous mosaicism, even when they occur in adult life. Adult blaschkitis (AB) and lichen striatus (LS) always follow this peculiar distribution. Although usually referred to as distinct entities, the clinical and histopathological presentation of lichen striatus in adults may be similar to those of adult blaschkitis.

Evaluation of carnitine deficit in very low birth weight preterm newborns small for their gestational age.

Objective: To verify whether small-for-gestational-age (SGA) preterm newborns represent a special risk group for carnitine deficiency. Secondary outcome includes assessment of longitudinal differences of total carnitine (TC), free carnitine (FC) and acylcarnitines between SGA and appropriate-for-gestational-age (AGA).

Methods: A retrospective study to evaluate carnitine and acylcarnitines profile on 144 very-low-birth weight newborns (VLBW), classified as AGA (n = 73) and SGA (n = 71), was performed by tandem mass spectrometry, during their first 5 weeks of life.

Non-Hodgkin's lymphoma presenting as a primary bladder tumor: a case report.

Introduction: Primary lymphoma of the bladder represents 0.2% of all bladder malignancies. Secondary involvement of the bladder by malignant lymphoma occurs in 10% to 50% of cases.

[Pharmacological treatment of hereditary haemorrhagic telangiectasia].

Hereditary hemorrhagic telangiectasia (HHT) of Rendu-Osler-Weber disease is a multi system vascular dysplasia characterized by the presence of multiple telangiectasias, mainly affecting mucosal tissue and arterial-venous connections. It commonly affects lungs, liver and central nervous system. Bleeding is the most common symptom and its treatment can be surgical or pharmacological.

[Demand for paediatric emergency care in a community hospital].

Objective: To study the characteristics of paediatric emergency demand and care delivery in the emergency room of a community hospital.

Design: Analysis of the care demand and medical attention given to pediatric patients in an emergency room during 2006. Retrospective review of patients' medical reports.

[Adequancy of the pharmacological disponibility in a Department of Internal Medicine to the WHO essential drug list].

Introduction: Since several years ago, the World Health Organization (WHO), publishes the Essential Drug List (EDL) including medicines that are used to cover the mayor health community problems. Drugs are selected in terms of importance, usefulness, safety and cost-effectiveness. There is no enough data about adequacy between this list and the current medical practise in Internal Medicine.

[Streptococcus constellatusas a causative agent of empyema. Report of one case].

Streptococcus constellatus is a commensal microorganism in man but may cause infections in different locations. We report a 59 years old male with severe sequelae of a previous cerebrovascular accident that consulted in the emergency room for fever of 15 days of evolution. A right empyema was diagnosed.

[Erectile dysfunction: an insufficiently valued problem in Internal Medicine. Study of patients and related medication].

Introduction: Erectile dysfunction (ED) is a common disease and may be due to psychological or organic causes. It might point to a silent disease and its value could not only be in life quality but also directly resolving the health problem laying beneath. The evaluation of ED begins with sexual records and physical examination which have been reported to have a 95 percent sensitivity, and a 50 percent specificity.

Lipoprotein(a) and lipid profile in patients with atrial fibrillation.

Background: Atrial fibrillation (AF) is well-known risk factor for cardiac embolic events, especially cerebrovascular events. The association between AF and lipid markers was evaluated. Among all these markers, lipoprotein(a), or (Lp(a), was also investigated.