2 results match your criteria: "Fundación Jiménez-Díaz University Hospital and Instituto de Investigación Sanitaria (IIS-FJD)[Affiliation]"
Prognostic significance of FLT3-ITD length in AML patients treated with intensive regimens.
Sci Rep
October 2021
Hematology Department, Hospital Universitario La Fe de Valencia, Valencia, Spain.
FLT3-ITD mutations are detected in approximately 25% of newly diagnosed adult acute myeloid leukemia (AML) patients and confer an adverse prognosis. The FLT3-ITD allelic ratio has clear prognostic value. Nevertheless, there are numerous manuscripts with contradictory results regarding the prognostic relevance of the length and insertion site (IS) of the FLT3-ITD fragment.
View Article and Find Full Text PDFEffects of negative-pressure therapy with and without ropivacaine instillation in the early evolution of severe peritonitis in pigs.
Eur J Trauma Emerg Surg
April 2021
Department of general and Digestive Surgery, Fundación Jiménez-Díaz University Hospital and Instituto de Investigación Sanitaria (IIS-FJD), Madrid, Spain.
Purpose: The abdomen is the second most common source of sepsis and secondary peritonitis, which likely lead to death. In the present study, we hypothesized that instillation of local anesthetics into the peritoneum might mitigate the systemic inflammatory response syndrome (SIRS) in the open abdomen when combined with negative-pressure therapy (NPT) to treat severe peritonitis.
Methods: We performed a study in 21 pigs applying a model of sepsis based on ischemia/reperfusion and fecal spread into the peritoneum.