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Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection.
Sci Rep
May 2021
Fundació Lluita Contra La SIDA (FLS) - Hospital Universitari Germans Trias I Pujol, Ctra. del Canyet, 08916, Badalona, Barcelona, Catalonia, Spain.
Article Synopsis
- INSTIs are crucial in current HIV treatment but their effects on brain health are not well understood.
- A study compared cognitive and brain function outcomes in men with HIV starting INSTI therapy within 3 months versus after 6 months of infection, alongside a control group.
- Findings showed no significant cognitive differences between the two HIV groups after 48 weeks, but those diagnosed earlier had poorer functional status initially, which improved over time; however, later initiators had more decline in a specific brain area linked to decision-making.