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Dissemination of nonpandemic Caribbean HIV-1 subtype B clades in Latin America.
AIDS
February 2015
aLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro bCentro de Desenvolvimento Científico e Tecnológico, Fundação Estadual de Produção e Pesquisa em Saúde cUniritter Laureate International Universities, Departamento de Ciências da Saúde dPrograma de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFGRS), Porto Alegre, Rio Grande do Sul, Brazil.
Article Synopsis
- The study aims to assess the prevalence of HIV-1 subtype B, focusing on the BPANDEMIC and BCAR clades in Latin America and to analyze how these strains spread over time in the region.
- Researchers examined 7,654 HIV-1 subtype B sequences from 18 countries collected between 1989 and 2011, using advanced statistical methods to understand their evolution and geographic spread.
- Findings indicate that nonpandemic BCAR strains likely spread from Caribbean islands into Latin America since the early 1970s, but the BPANDEMIC clade remains the dominant strain, making up over 90% of subtype B infections in most countries, with some exceptions.