1 results match your criteria: "Fukushima Medical University School of Medicine (YK)[Affiliation]"
Distinctive changes in histone H3K4 modification mediated via Kdm5a expression in spermatogonial stem cells of cryptorchid testes.
J Urol
May 2014
Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya and Department of Urology, Fukushima Medical University School of Medicine (YK), Fukushima, Japan.
Article Synopsis
- Gonocytes develop into spermatogonial stem cells, crucial for continuous sperm production, but their differentiation is poorly understood, especially in cases of cryptorchidism (undescended testes) affecting fertility.
- A microarray analysis showed significant changes in gene expression between normal and undescended testes in rat models, identifying 24 up-regulated and 39 down-regulated genes, with Kdm5a being notably higher in cryptorchid testes.
- Kdm5a appears to facilitate the differentiation process by regulating specific genes through histone modification, indicating that both genetic and epigenetic factors play significant roles in early spermatogenesis, marking it as the first study to explore this aspect.