70,867 results match your criteria: "Fukuoka University; 8-19-1 Nanakuma[Affiliation]"
Unraveling the Implications of Digit Bias in Digital Health - A Literature Review.
Intern Med
December 2024
Department of Cardiovascular Medicine, St. Luke's International Hospital, Japan.
Article Synopsis
- Digital health combines advanced technologies in healthcare, focusing on the digitization of continuous analog data into a discrete digital format, which is essential yet challenging.
- The digitization process can lead to information loss, reducing the data's richness and complexity, along with cognitive biases like "digit preferences" and "left digit bias" affecting how healthcare providers interpret digital data.
- Despite recognizing these potential distortions, the impact of digitization on healthcare has not been thoroughly studied, indicating a need for more research in this area.
Evaluation of Renal Perfusion: A Comparative Study between Intravoxel Incoherent Motion (IVIM) Imaging and Arterial Spin Labeling (ASL) to Assess Renal Blood Flow in Rodents.
Magn Reson Med Sci
December 2024
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- The study aimed to compare the effectiveness of intravoxel incoherent motion (IVIM) imaging and arterial spin labeling (ASL) in evaluating renal blood flow in rodent models of acute kidney injury (AKI).
- Researchers tested three fitting methods on diffusion-weighted imaging data to assess the reliability of pseudo-diffusion parameters and their ability to correlate with renal blood flow.
- Findings revealed that while ASL effectively detected a significant drop in renal blood flow due to AKI, IVIM's pseudo-diffusion parameters were not reliable or correlated, suggesting the need for careful consideration when interpreting results using IVIM in kidney studies.
Sociodemographic characteristics of maternal mortality in Japan: An analysis of national data from 2010 to 2022.
Eur J Obstet Gynecol Reprod Biol
February 2025
Medical Information Center, Kyushu University Hospital, Fukuoka City, Japan. Electronic address:
Article Synopsis
- The study aims to explore the sociodemographic factors affecting maternal mortality in Japan, as little research on this topic exists.
- It utilized national Vital Statistics data from 2010 to 2022 to analyze various sociodemographic characteristics, including maternal age, nationality, marital status, and household occupation.
- The findings revealed that non-Japanese mothers and unmarried mothers had significantly higher maternal mortality rates, with household occupation also influencing these rates, highlighting key sociodemographic influences on maternal health outcomes.
The search for blood biomarkers useful in treating atopic dermatitis patients.
Expert Rev Clin Pharmacol
December 2024
Department of Post-Infectious Diseases Therapeutics, Graduate School of Medicine, Osaka University, Suita, Japan.
Article Synopsis
- Atopic dermatitis (AD) is primarily diagnosed through observable symptoms rather than specific lab tests, leading to a push for new biomarkers to help guide treatment with emerging targeted therapies.
- A recent study and literature review highlight several potential biomarkers for AD, with an emphasis on the effectiveness of CCL17/TARC, but also noting others like SCCA2, CCL26/eotaxin-3, and LDH as potentially better markers for assessing disease severity.
- Further research is needed to identify and validate these biomarkers to improve treatment outcomes for patients with atopic dermatitis.
Editorial Comment.
J Urol
December 2024
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
A Vaccine Against Fibroblast Activation Protein Improves Murine Cardiac Fibrosis by Preventing the Accumulation of Myofibroblasts.
Circ Res
January 2025
Department of Health Development and Medicine (S.Y., H.H., J.S., S.B., H.N.), Osaka University Graduate School of Medicine, Japan.
Article Synopsis
- - The study focused on myofibroblasts and how a vaccine targeting fibroblast activation protein (FAP) might help reduce cardiac fibrosis in mice with chronic cardiac stress.
- - Mice were vaccinated with a FAP peptide while undergoing continuous treatment with angiotensin II and phenylephrine, resulting in a significant decrease in both cardiac fibrosis and the number of myofibroblasts.
- - The findings suggest that the FAP vaccine is a promising therapeutic option for cardiac fibrosis without causing harmful side effects in other injury models, indicating its potential for future treatments.
A novel strategy to protect prokaryotic cells from virus infection.
Eng Microbiol
June 2024
Department of Bioscience and Biotechnology, Graduate school of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 819-0395, Japan.
Article Synopsis
- The discovery of the CRISPR-Cas system emphasizes that we still have a lot to learn about how bacteria and archaea defend against viruses.
- Researchers are continuously finding new immune systems in prokaryotes, which adds to our understanding of viral defense.
- A recent study identified a new enzyme (glycosylase) that targets a specific modified base in the T4 phage genome, preventing the virus from replicating by creating an abasic site.
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan.
Geroscience
December 2024
Center for Liberal Arts, Fukuoka Institute of Technology, 3-30-1 Wajiro-Higashi, Higashi-Ku, Fukuoka, 811-0295, Japan.
Article Synopsis
- * In a 10-year study of 1,597 Japanese adults aged 65 and older who were free of dementia and disability at the start, 488 participants developed functional disabilities.
- * The research highlighted a significant interaction between cognitive impairment and physical frailty, suggesting that addressing cognitive frailty could be crucial in preventing functional disabilities among the elderly.
A retrospective study of seasonal variation in sodium-glucose co-transporter 2 inhibitor-related adverse events using the Japanese adverse drug event report database.
Sci Rep
December 2024
Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4, Daigaku-nishi, Gifu, 501-1196, Japan.
Article Synopsis
- * The study identified seasonal trends in adverse events like dehydration, cerebral infarction, urinary tract infections, and ketoacidosis linked to six SGLT2 inhibitors prescribed in Japan.
- * Findings showed dehydration-related issues were most common in summer and winter, with a peak for cerebral infarction in February, suggesting healthcare professionals should be vigilant about dehydration risks throughout the year.
Design and simulation of CsPb.Zn.IBr-based perovskite solar cells with different charge transport layers for efficiency enhancement.
Sci Rep
December 2024
School of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Article Synopsis
- The study focuses on simulating and optimizing CsPb.Zn.IBr-based perovskite solar cells (PSCs) using the SCAPS-1D simulator to explore how different hole transport layers (HTL) and electron transport layers (ETL) impact device performance.
- After optimizing the HTL, the best power conversion efficiency (PCE) recorded was 16.59% with the FTO/SnS/CsPb.Zn.IBr/MoS/Au structure, while further improvements in thickness and charge carrier densities led to a maximum PCE of 21.05% for the FTO/ZnSe/CsPb.Zn.IBr/MoS/Au configuration.
- The research highlights
A Novel Oncolytic Viral Therapy Using Coxsackievirus B3 (CVB3) for Human Pancreatic Cancer Including Cancer-associated Fibroblasts.
Anticancer Res
December 2024
Project division of ALA advanced medical research, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Article Synopsis
- Pancreatic cancer is highly aggressive with a 5-year survival rate under 10%, and cancer-associated fibroblasts (CAFs) play a crucial role in tumor growth and drug resistance.
- The study found that coxsackievirus B3 (CVB3) effectively kills both pancreatic cancer cells and CAFs, showing its potential as a dual-action treatment.
- CVB3 could be developed as a new oncolytic virotherapy, aiming to enhance drug sensitivity and improve outcomes for pancreatic cancer patients.
Prognostic Significance of Innovative Inflammation-nutrition Biomarker Score in Patients With Colorectal Cancer.
Anticancer Res
December 2024
Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- A new inflammation-nutrition biomarker score (INS) was developed to assess post-operative survival in colorectal cancer patients, showing promise beyond traditional TNM staging.
- In a study of 476 patients who had curative surgery for stage I-III colorectal cancer, those with higher INS scores (2-4) experienced significantly worse relapse-free and overall survival rates compared to those with lower scores (0-1).
- The research suggests that using INS alongside TNM staging could improve survival predictions in colorectal cancer patients.
Enhancing Estimation Accuracy of Prostate Cancer VMAT Planning: A Knowledge-based Approach Using Multiple Collimator Angles.
Anticancer Res
December 2024
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osaka, Japan.
Article Synopsis
- * Five healthcare institutions tested this model on prostate cancer treatments, comparing how well each model could estimate dosimetric parameters and plan quality.
- * Results showed the Multi-coll. model was more accurate in its estimates and provided better plan quality, particularly in reducing radiation exposure to the rectum and bladder.
Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans.
Blood Adv
February 2025
Ragon Institute of Mass General, Massachusetts Institute of Technology, and Harvard, Cambridge, MA.
Patients with cytotoxic T-lymphocyte-associated protein 4 (CTLA4) deficiency exhibit profound humoral immune dysfunction, yet the basis for the B-cell defect is not known. We observed a marked reduction in transitional-to-follicular (FO) B-cell development in patients with CTLA4 deficiency, correlating with decreased CTLA4 function in regulatory T cells, increased CD40L levels in effector CD4+ T cells, and increased mammalian target of rapamycin complex 1 (mTORC1) signaling in transitional B cells (TrBs). Treatment of TrBs with CD40L was sufficient to induce mTORC1 signaling and inhibit FO B-cell maturation in vitro.
View Article and Find Full Text PDFHydrogen-Assisted Mg Intercalation into 2H-TaS.
J Am Chem Soc
December 2024
Research Institute for Electronic Science, Hokkaido University, Kita 20 Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan.
Article Synopsis
- - Intercalation reactions depend on how the electronic and structural properties of host (like TaS) and guest materials (like divalent ions) interact, making it harder for divalent ions like Mg to intercalate compared to monovalent ions.
- - This study explores the cointercalation of Mg and hydrogen (H) into TaS to produce bulk polycrystalline MgHTaS, where hydrogen can be removed by heating at around 400 °C without changing the crystal structure.
- - The research also investigates how the superconducting properties relate to electronic carrier density using both theoretical calculations and experiments, highlighting the benefits of using hydrides for intercalation reactions.
Direct simulation and machine learning structure identification unravel soft martensitic transformation and twinning dynamics.
Proc Natl Acad Sci U S A
December 2024
National Institute of Advanced Industrial Science and Technology, Research Center for Computational Design of Advanced Functional Materials, Tsukuba, Ibaraki 305-8568, Japan.
Article Synopsis
- The text examines phase transitions, specifically martensitic transformations, which involve the movement of atoms in a coherent way to shift from one crystalline structure to another, and highlights recent experimental observations in soft materials.
- The study utilizes direct simulations of a liquid crystalline blue phase (BP II) to analyze the dynamic transition to another phase (BP I) through a machine-learning approach to identify local structures and defects.
- Findings reveal that this transformation can be triggered by the breakup of line defect junctions and can be reversed by changing temperature, shedding light on complex structural changes in ordered materials more broadly.
Article Synopsis
- The study examines how bariatric/metabolic surgery affects the incidence and severity of COVID-19 among patients in Japan, amidst ongoing debates about its protective benefits.
- Data were collected from 83 institutions, revealing that while there were no severe cases or deaths among 119 patients studied, moderate COVID-19 cases were notably more prevalent in these bariatric patients than in the general population.
- The findings suggest that bariatric/metabolic surgery does not reduce the risk of COVID-19 complications, as moderate cases were linked to specific risk factors such as dyslipidemia and prior infection.
Allogeneic hematopoietic stem cell transplantation using reduced intensity conditioning regimen for patients with acute myeloid leukemia not in complete remission.
Cytotherapy
November 2024
Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- * The research included 707 adults and found that the 5-year progression-free survival (PFS) rate was 18.8%, with overall survival at 22.0%, and identified key factors affecting outcomes, such as male sex, poor performance status, karyotype risk, and blasts in the blood.
- * These findings provide valuable insights into the prognosis and treatment strategies for R/R AML, influencing future
Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice.
Genes Cells
January 2025
Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Article Synopsis
- Abnormalities in spermatogenesis can lead to male infertility, highlighting the importance of testicular somatic cells in this process.
- In a study using mice with a specific gene deletion, researchers found that the absence of normal spermatogenesis caused increased Leydig cell numbers and interstitial space in the testis.
- The increase in Leydig cells correlated with higher testosterone production and signs of cellular aging, suggesting they play a role in supporting germ cell development during spermatogenesis.
Aberrant extracellular dopamine clearance in the prefrontal cortex exhibits ADHD-like behavior in NCX3 heterozygous mice.
FEBS J
January 2025
Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Article Synopsis
- ADHD is linked to dopaminergic dysfunction in the prefrontal cortex, leading to symptoms like hyperactivity, inattention, and cognitive deficits.
- Researchers identified sodium-calcium exchanger 3 (NCX3) in dopaminergic neurons, finding that its knockdown causes abnormal dopamine influx and related behavioral issues in mice.
- NCX3 heterozygous mice display ADHD-like behaviors, such as hyperactivity and cognitive deficits, which can be improved with methylphenidate, highlighting the role of NCX3 in dopamine signaling and ADHD.
Article Synopsis
- ADHD symptoms can continue into adulthood, affecting areas like executive function, emotional regulation, and motivation, yet there's limited research on effective treatment options such as cognitive behavioral therapy (CBT) in Japan.
- This study aims to evaluate a new, culturally-adapted CBT program for adult ADHD patients in Japan, involving 12 participants in an open, multicenter format over a period of 24-28 weeks.
- The main focus will be on assessing the feasibility of this CBT program through dropout rates and clinical severity score changes, while also examining long-term treatment effects and related factors like depression and quality of life.
Association of Neuropsychiatric Inventory Questionnaire Score With Caregiver Relationship in Alzheimer's Disease Dementia and Mild Cognitive Impairment.
J Appl Gerontol
December 2024
Department of Occupational Therapy, Kyoto Tachibana University, Kyoto, Japan.
Article Synopsis
- - The study investigated the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease dementia (ADD) and mild cognitive impairment (MCI), focusing on how caregiver relationships affect these symptoms.
- - Researchers evaluated cognitive function in 419 patients using two tests and found significant connections between caregiver relationships and factors like patient age, education level, and total BPSD scores based on the Neuropsychiatric Inventory Questionnaire (NPI-Q).
- - Specific symptoms such as delusions and irritability were notably tied to the caregiver’s relationship with the patient, with female caregivers reporting higher scores in certain emotional symptoms, indicating that the caregiver’s role can influence the patient’s psychological state.
Prevalence and Incidence of Peutz-Jeghers Syndrome and Juvenile Polyposis Syndrome in Japan: A Nationwide Epidemiological Survey in 2022.
J Gastroenterol Hepatol
December 2024
Division of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Article Synopsis
- Peutz-Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) are hereditary conditions linked to a high risk of cancer, but their prevalence and incidence in Japan were previously unknown.
- A nationwide survey in 2022 revealed that there are an estimated 701 patients with PJS and 188 with JPS in Japan, with low prevalence and incidence rates highlighted.
- Results also showed a higher male representation in both conditions and indicated a need for further research on clinical details and outcomes associated with these syndromes.
Exploring the tumor microenvironment of colorectal cancer patients post renal transplantation by single-cell analysis.
Cancer Sci
December 2024
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Article Synopsis
- * Analysis through single-cell RNA sequencing identified significant changes in immune cell function in transplant recipients, including reduced cytotoxicity in CD8 T cells and increased inhibitory activity in regulatory T cells within tumors.
- * Findings highlight the potential for developing targeted immunotherapies to improve patient outcomes in renal transplant recipients with colorectal cancer, based on the unique immune landscape observed.
A transphyletic study of metazoan β-catenin protein complexes.
Zoological Lett
December 2024
Evolutionary Neurobiology Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Beta-catenin is essential for diverse biological processes, such as body axis determination and cell differentiation, during metazoan embryonic development. Beta-catenin is thought to exert such functions through complexes formed with various proteins. Although β-catenin complex proteins have been identified in several bilaterians, little is known about the structural and functional properties of β-catenin complexes in early metazoan evolution.
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