4,283 results match your criteria: "Fujita Health University School of Medicine[Affiliation]"
The polymyxin-B direct hemoperfusion OPTimal Initiation timing with Catecholamine PMX-OPTIC study: A multicenter retrospective observational study.
Artif Organs
September 2024
Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Background: Polymyxin-B direct hemoperfusion (PMX-DHP) is an endotoxin adsorption column-based blood purification therapy. Since one of the most potent effects of PMX-DHP is blood pressure elevations, it may be the most effective when it is introduced at the time when the need for vasopressors is the greatest, which, in turn, may reduce mortality.
Methods: A multicenter retrospective study was conducted at 24 ICUs in Japan.
Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma.
NPJ Precis Oncol
September 2024
Department of Urology, Osaka Medical and Pharmaceutical University, Takatsuki City, Osaka, Japan.
Hyper progressive disease (HPD) is a paradoxical phenomenon characterized by accelerated tumor growth following treatment with immune checkpoint inhibitors. However, the pathogenic causality and its predictor remain unknown. We herein report a fatal case of HPD in a 50-year-old man with metastatic bladder cancer.
View Article and Find Full Text PDFEditorial for "Comparative Study Between Variable Flip Angle and Modified Look-Locker Inversion Recovery for Evaluating Renal Interstitial Fibrosis".
J Magn Reson Imaging
September 2024
Department of Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Japan.
Mesothelioma Mimicking a Mediastinal Tumor in the Prevascular Compartment: A Case Report.
J Thorac Imaging
November 2024
Department of Diagnostic Radiology, Fujita Health University School of Medicine.
Diagnostic potential of SDHB mRNA contained in serum extracellular vesicles among patients with prostate cancer.
Prostate
December 2024
Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, Toyoake, Japan.
Article Synopsis
- Researchers focused on identifying new serum extracellular vesicle (EV)-based biomarkers for detecting resistance to androgen receptor signaling inhibitors (ARSIs) in metastatic prostate cancer (PC) and castration-resistant prostate cancer (CRPC).
- They used RNA-sequencing on serum EVs from CRPC patients before and after developing ARSI-resistance to analyze changes in gene expression, particularly looking at mitochondrial oxidative phosphorylation (OXPHOS)-related genes.
- The study found that SDHB mRNA levels were significantly higher in EVs from ARSI-resistant CRPC patients, suggesting that EV-SDHB could serve as a novel biomarker for early diagnosis of ARSI-resistance.
Serum mature and furin-cleaved proprotein convertase subtilisin/kexin type 9 levels and their association with cardiovascular events in statin-treated patients with cardiovascular disease.
J Clin Lipidol
November 2024
Jichi Medical University, Shimotsuke, Japan (Dr Nagai).
Article Synopsis
- Previous studies showed inconsistent links between PCSK9 levels and cardiovascular event risk due to improper measurement methods.
- This study is a sub-analysis of the REAL-CAD trial, which compared the effects of high and low-dose statin therapy on cardiovascular outcomes in stable coronary artery disease patients.
- The results indicated that neither mature nor furin-cleaved PCSK9 levels effectively predicted major adverse cardiovascular events, suggesting they are not useful markers in statin-treated patients.
Orexin receptor antagonists in the treatment of insomnia associated with psychiatric disorders: a systematic review.
Transl Psychiatry
September 2024
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Article Synopsis
- * This systematic review analyzed two dual orexin receptor antagonists (DORAs), lemborexant and suvorexant, for treating insomnia in patients with psychiatric conditions, reviewing 21 studies from various clinical sources.
- * Preliminary findings suggest that DORAs may be just as effective and safe for addressing insomnia linked to psychiatric disorders as they are for primary insomnia, but further research is needed due to limited evidence from small studies.
Neoself-antigens are the primary target for autoreactive T cells in human lupus.
Cell
October 2024
Laboratory of Immunochemistry, World Premier International Immunology Frontier Research Centre, Osaka University, Osaka 565-0871, Japan; Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; Center for advanced modalities and DDS, Osaka University, Osaka 565-0871, Japan; Center for Infectious Disease Education and Research, Osaka University, Osaka 565-0871, Japan. Electronic address:
Article Synopsis
- * Neoself-antigens, which are unusual self-targets, are presented on MHC-II when the invariant chain is absent, leading to the activation of autoreactive T cells in SLE.
- * Research shows that these neoself-reactive T cells expand in SLE patients and can be activated by cells reactivated by the Epstein-Barr virus, indicating a significant relationship between viral infections and the development of lupus.
A descriptive review on the real-world impact of Moderna, Inc. COVID-19 vaccines.
Expert Rev Vaccines
October 2024
Departments of Microbiology and Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Japan.
Introduction: Since the original COVID-19 vaccines were developed, abundant clinical trial and real-world evidence evaluating the efficacy, effectiveness, and safety of COVID-19 vaccines has been collected. Knowledge of the relative benefits and risks of COVID-19 vaccines is essential for building trust within target populations, ensuring they remain effectively and safely protected against an enduring infectious threat.
Areas Covered: This descriptive review discusses the benefits and risks associated with marketed Moderna, Inc.
Epidemiology and molecular evolution of GI.1 sapovirus in the recent era.
J Med Virol
September 2024
Department of Pathology and Microbiology, Nihon University School of Medicine, Division of Microbiology, Tokyo, Japan.
Article Synopsis
- Sapovirus (SaV) infections are on the rise globally, with a notable increase in Japan from 2010 to 2022, mainly due to the GI.1 genotype.
- The study analyzed 15 SaV GI.1 outbreak strains using next-generation sequencing and found distinct clustering in lineages and specific amino acid substitutions in their genomes.
- Key mutations associated with the pathogenicity and spread of SaV were identified in strains responsible for the largest outbreak in Japan (2021-2022), enriching the understanding of SaV's genetic makeup.
Dynamic Pathology of Enteric Neural Network using Curcumin-assisted Multiphoton Laser Imaging in Hirschsprung Disease.
Ann Surg
September 2024
Departments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine; Tsu, Japan.
Objective: In living tissue, it has been difficult to make microscopic-level observations without damaging the tissue.
Summary Background Data: We have invented a novel intravital fluorescent observation method (IFOM) for real-time tissue observation, combining multi-photon laser scanning microscopy (MPLSM) with curcumin vital staining (CVS-IFOM). The aim of this study was to use CVS-IFOM to analyze the enteric nervous system (ENS) in mice and human patients with hypoganglionosis and Hirschsprung disease.
Clinical significance of direct fast scarlet staining on the diagnosis of eosinophilic colitis: A comparative study focusing on the eosinophil degranulation in colonic mucosal tissue.
Pathol Int
November 2024
Department of Gastroenterological Surgery, Fujita Health University School of Medicine Bantane Hospital, Nagoya, Aichi, Japan.
Article Synopsis
- This study validated the effectiveness of DFS (direct fast scarlet) staining for diagnosing eosinophilic colitis (EC) by comparing it with standard HE (hematoxylin and eosin) staining among 50 EC patients and 60 control subjects.
- Results showed a significant difference in eosinophil counts between EC and controls in the right hemi-colon but not in the left, where DFS staining proved crucial for identifying degranulated eosinophils, enhancing diagnostic accuracy.
- The study suggests that using DFS staining can improve the diagnosis of EC, especially in challenging areas like the left hemi-colon, where traditional methods fell short.
Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning.
Sci Signal
September 2024
Division of Cell Biology, International Center for Brain Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Structural plasticity of dendritic spines in the nucleus accumbens (NAc) is crucial for learning from aversive experiences. Activation of NMDA receptors (NMDARs) stimulates Ca-dependent signaling that leads to changes in the actin cytoskeleton, mediated by the Rho family of GTPases, resulting in postsynaptic remodeling essential for learning. We investigated how phosphorylation events downstream of NMDAR activation drive the changes in synaptic morphology that underlie aversive learning.
View Article and Find Full Text PDFEfficacy of compressed sensing and deep learning reconstruction for adult female pelvic MRI at 1.5 T.
Eur Radiol Exp
September 2024
Department of Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Japan.
Article Synopsis
- A study compared compressed sensing (CS) with deep learning reconstruction (DLR) to traditional parallel imaging (PI) for enhancing image quality and reducing scan time in female pelvic MRI at 1.5-T.
- Results showed that CS combined with DLR yielded significantly higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) for both T1 and T2-weighted images, indicating improved diagnostic performance.
- The findings concluded that using CS with DLR is more effective than PI, providing better image quality and shorter examination times for female pelvic MRIs.
Frequency of cefiderocol heteroresistance among patients treated with cefiderocol for carbapenem-resistant infections.
JAC Antimicrob Resist
October 2024
Department of Clinical and Experimental Medicine, Azienda Osperdaliero Universitaria Pisana, University of Pisa, Pisa, Italy.
Article Synopsis
- - The study investigates the role of heteroresistance in cefiderocol treatment failure among patients with carbapenem-resistant Acinetobacter baumannii (CRAb) infections, finding a significant portion (59%) of the isolates had heteroresistance, particularly higher in Italy compared to the USA.
- - Patients with cefiderocol-heteroresistant strains had worse clinical outcomes, with 81% experiencing treatment failure, compared to 55% for those with susceptible strains, and higher minimum inhibitory concentrations (MICs) were linked to increased failure rates.
- - Whole-genome sequencing revealed a genetic mutation in some heteroresistant isolates, supporting the idea that both higher MICs and the presence of resistant subpopulations contribute to
Measurement of changes in serum-based inflammatory indicators to monitor response to nivolumab monotherapy in advanced gastric cancer: a multicenter retrospective study.
BMC Cancer
September 2024
Department of Surgery, Fujita Health University School of Medicine, 1-98, Dengakugakubo, Kutsukake, Toyoake, 470-1192, Aichi, Japan.
Article Synopsis
- - This study focused on 111 patients with advanced gastric cancer who were treated with nivolumab to monitor their disease progression and evaluate treatment response using serum inflammatory markers like CRP-to-albumin ratio (CAR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR).
- - Results indicated an overall response rate of 11.7% and a disease control rate of 44.1%, with median overall survival of 14 months and progression-free survival of 4.1 months.
- - Changes in the inflammatory markers after therapy proved to be useful in predicting treatment response, with specific cutoff values identified for CAR, PLR, and NLR that correlated
Uric acid and alterations of purine recycling disorders in Parkinson's disease: a cross-sectional study.
NPJ Parkinsons Dis
September 2024
Department of Neurology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.
The relationship between reduced serum uric acid (UA) levels and Parkinson's disease (PD), particularly purine metabolic pathways, is not fully understood. Our study compared serum and cerebrospinal fluid (CSF) levels of inosine, hypoxanthine, xanthine, and UA in PD patients and healthy controls. We analyzed 132 samples (serum, 45 PD, and 29 age- and sex-matched healthy controls; CSF, 39 PD, and 19 age- and sex-matched healthy controls) using liquid chromatography-tandem mass spectrometry.
View Article and Find Full Text PDFLong-Term Outcome of Eltrombopag With First-Line Immunosuppressive Therapy for Newly Diagnosed Severe Aplastic Anemia.
J Hematol
August 2024
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Background: To investigate whether the addition of eltrombopag (EPAG) to rabbit anti-thymocyte globulin (ATG)-based immunosuppressive therapy (IST) for newly diagnosed severe aplastic anemia (SAA) improves outcomes and affects the cumulative incidence of clonal evolution (CE), we conducted a multicenter retrospective analysis.
Methods: Data were collected from 101 patients, aged 15 - 65 years, undergoing initial IST.
Results: No significant imbalance in age, sex, or severity was observed between the EPAG (n = 20) and non-EPAG (n = 81) groups.
Randomized open-label study of second-generation antipsychotics for the treatment of schizophrenia: 104-week final results of the JUMPs study assessing treatment discontinuation, remission, and social functioning.
BMC Psychiatry
September 2024
Department of Neuropsychiatry, Kokubu Hospital, 4-672 Asahigaoka, Kashiwara-shi, Osaka, 582-0026, Japan.
Article Synopsis
- The study analyzed the effectiveness of three antipsychotic medications—aripiprazole, blonanserin, and paliperidone—over a 104-week period for patients with schizophrenia as part of the Japan Useful Medication Program for Schizophrenia (JUMPs).
- A total of 251 patients were treated, with similar treatment discontinuation rates across all medications, and positive improvements in quality of life and symptom scores were noted over time.
- The findings indicate that while treatment results were comparable, continuing with these medications can lead to improved remission rates and overall quality of life for patients.
Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections.
J Antimicrob Chemother
November 2024
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.
Background: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream infections (BSI).
Methods: Patients prospectively enrolled in CRACKLE-2 from 56 hospitals in 10 countries between 30 April 2016 and 30 November 2019 with a CRE BSI were eligible.
Propensity Score-matched Analysis Comparing Robotic Versus Laparoscopic Minor Liver Resections of the Anterolateral Segments: an International Multi-center Study of 10,517 Cases.
Ann Surg
September 2024
Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore.
Article Synopsis
- A study was conducted to compare robotic minor liver resections (RMLR) with laparoscopic minor liver resections (LMLR) in patients undergoing surgery on the anterolateral liver segments.
- The analysis included over 10,000 patients and employed propensity score matching to balance the groups for accuracy in comparisons.
- Results indicated RMLR had benefits like less blood loss, lower major morbidity, and shorter hospital stays than LMLR, although the difference in 30-day readmission rates suggested RMLR may have some drawbacks.
Comparative Effectiveness of Decision Aids for Cancer-Screening Decision Making: An Overview of Reviews.
J Gen Intern Med
December 2024
Department of Emergency Medicine and General Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Background: Decision aids (DAs), compared to no DAs, help improve the key aspects of shared decision-making, including increased knowledge, discussion frequency, and reduction in decisional conflict. However, systematic reviews have reported varied conclusions on screening uptake, and which DAs are superior to alternative forms in shared decision-making for cancer screening has not been comprehensively reviewed.
Methods: An overview of systematic reviews was performed.
Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?
Ann Gastroenterol Surg
September 2024
Second Department of Surgery Wakayama Medical University, School of Medicine Wakayama Japan.
Article Synopsis
- * Analyzing data from 1183 patients, it found that completing 6 months of postoperative adjuvant therapy significantly improved overall, disease-specific, and recurrence-free survival, especially for high-risk patients.
- * Additionally, neoadjuvant therapy showed benefits for those with borderline resectable IPMC, and any treatment for recurrence after surgery was linked to longer survival compared to no treatment.
Analysis of the clinical features and outcomes of relapsed intravascular large B-cell lymphoma: a single center study.
Leuk Lymphoma
December 2024
Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa-shi, Japan.
Clinical utility of swept-source optical coherence tomography angiography for the diagnosis of exudative maculopathy.
Jpn J Ophthalmol
November 2024
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Article Synopsis
- The study evaluates the effectiveness of swept-source optical coherence tomography angiography (SS-OCTA) in distinguishing various macular diseases without using indocyanine green angiography (ICGA).
- It involves a review of 63 eyes from patients with treatment-naive neovascular age-related macular degeneration (AMD) and finds that SS-OCTA accurately identifies conditions like nonpolypoidal macular neovascularization (MNV) and polypoidal choroidal vasculopathy (PCV) with high sensitivity and specificity.
- The results suggest that SS-OCTA can be a viable alternative to ICGA for diagnosing these macular diseases, offering a reliable method for ophthalmologists to make decisions.