2,056 results match your criteria: "Fujigaoka Hospital[Affiliation]"

Article Synopsis
  • The study aimed to assess the effects of starting sacubitril/valsartan (Sac/Val) therapy during hospitalization for acute heart failure (AHF) on NT-proBNP levels in Japanese patients.
  • It involved a randomized trial with 400 patients, comparing those who switched to Sac/Val versus those who continued standard therapy, measuring changes in NT-proBNP at 4 and 8 weeks.
  • Results showed that the Sac/Val group experienced significantly greater reductions in NT-proBNP levels, particularly in patients with lower left ventricular ejection fractions, with no significant safety concerns noted.
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Aims: Left atrial (LA) volume index (LAVI) in chronic heart failure (HF) predicts cardiovascular outcomes. However, the association between LAVI reduction during acute decompensated HF (ADHF) and its prognostic potential is limited. We hypothesized that LA reverse remodelling (LARR) after ADHF therapy would be associated with better clinical outcomes.

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Background: The characteristics of patients with advanced chronic kidney disease (CKD) who are recipients of public assistance in Japan, and the adequacy of their medical care have not been reported previously.

Methods: The records of patients with CKD stage G5 who visited nine facilities in Japan from April to June 2013 were retrospectively reviewed to compare the characteristics and care of recipients of public assistance with those of non-recipients. Receiving a presentation of kidney replacement therapy (KRT) options and polypharmacy were used as indicators of suboptimal medical care.

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Background: The benefit of prehospital 12‑lead electrocardiogram (PH-ECG) performed by emergency medical service personnel at the site of first medical contact (FMC) in patients with ST-segment elevation myocardial infarction (STEMI) with cardiogenic shock (CS-STEMI) remains unclear. This study aimed to investigate the effect of PH-ECG on door-to-device time in patients with CS-STEMI.

Methods: This study enrolled CS-STEMI (Killip class IV) patients who were transferred directly to hospitals by ambulance (n = 517) from the Kanagawa Acute Cardiovascular Registry database.

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Article Synopsis
  • Autoimmune encephalitis is a rapidly progressive brain disease; the GABA receptor subtype has unique symptoms that make diagnosis difficult, especially when typical signs are missing.
  • A 59-year-old man's case illustrates that cerebellar symptoms like gait disturbances occurred without cognitive decline, and initial tests were inconclusive, delaying effective treatment.
  • Successful treatment with immunosuppressive therapies led to improvement, emphasizing the need for awareness of autoimmune causes in cases with normal imaging results and highlighting how early intervention can positively affect patient outcomes.
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Article Synopsis
  • * Researchers examined temporal bones from donors with otosclerosis to assess RW obliteration and its relation to other otosclerosis patterns.
  • * Findings indicate a significant rate of RW involvement, with continuous lesions from the oval window leading to complete RW obliteration, potentially improving future prognostic evaluations for otosclerosis patients.
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Background: Curved varus osteotomy (CVO) is an effective femoral head-preserving surgical procedure for osteonecrosis of the femoral head (ONFH) classified as type B or C1 according to the Japanese Investigation Committee (JIC) classification; it reportedly provides better postoperative outcomes than transtrochanteric rotational osteotomy (TRO). We have developed a new procedure called spherical varus rotational osteotomy (SVRO) in which osteotomy of the femur into a spherical shape is followed by varus and anterior rotation using navigation to increase indications and improve postoperative outcomes.

Methods: Nine joints of eight patients who underwent SVRO and could be followed up for > 1 year were included in the study.

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Purpose: The purpose of this study was to examine the location where the femoral artery contacts the vastus medialis at the adductor tendon hiatus, which is important when using the subvastus approach in medial closed wedge distal femoral osteotomy. We evaluated the correlation between differences in height, vastus medialis morphology, and lower limb alignment.

Methods: Sixty knees (16 male, 44 female) that underwent plain computer tomography (CT) were included.

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Article Synopsis
  • Current guidelines suggest avoiding anticoagulation after PCI for acute coronary syndrome (ACS), but this recommendation lacks strong evidence.
  • In a study analyzing outcomes of patients with ACS who did or did not receive post-PCI heparin, those receiving heparin had a significantly higher risk of bleeding and a slightly increased risk of cardiovascular events.
  • The use of post-PCI heparin in ACS patients was common, but it was linked to increased bleeding without demonstrating any clear benefit in reducing serious cardiovascular outcomes.
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Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is routinely prescribed as first-line therapy for advanced non-small cell lung cancer, regardless of the presence of the T790M resistance mutation. This study reports a rare case of Factor V inhibitor detection during osimertinib therapy in a patient with lung adenocarcinoma. These findings underscore the importance of vigilant monitoring for coagulation abnormalities during EGFR-TKI therapy.

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Objectives: Despite otitis media and various disease processes being associated with endolymphatic hydrops (EH), an exact explanation of the pathophysiology has yet to be reported. This study aimed to investigate the changes in the cochlear lateral wall structures and their potential correlation with the presence and severity of cochlear EH in acute and chronic otitis media cases. The investigations were conducted in both chinchilla animal model and human temporal bone specimens.

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Background: Liquid embolization in neuroendovascular procedures carries the risk of embolizing an inappropriate vessel. Operators must pay close attention to multiple vessels during the procedure to avoid ischemic complications. We report our experience with real time artificial intelligence (AI) assisted liquid embolization and evaluate its performance.

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Article Synopsis
  • Recent studies indicate that calcified nodules (CN) in patients with acute coronary syndrome (ACS) are linked to worse health outcomes.
  • The study involved 695 ACS patients and found that those with OCT-defined CN were typically older and had higher incidences of diabetes, hemodialysis, and severe heart failure compared to those without CN.
  • Key predictors for the presence of OCT-CN included age, hemodialysis, and Killip Class III/IV heart failure, suggesting that these factors could indicate increased lesion severity and poorer prognosis for ACS patients.
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Older adults often experience poor oral functions, hindering rehabilitation post-acute disease treatment. However, characteristics of hospitalized patients who would benefit from professional oral-health management (POHM) have not been clarified. Therefore, we aimed to elucidate systemic and oral characteristics of patients requiring POHM during hospitalization in a convalescent hospital.

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Article Synopsis
  • This study investigates the impact of eruptive calcified nodules (CNs) on patient outcomes after percutaneous coronary intervention (PCI) compared to other calcified lesions, finding worse results for those with CNs.
  • Researchers analyzed data from 51 patients who underwent PCI for calcified lesions, revealing that 54% of those with eruptive CNs had in-stent CNs at the 8-month follow-up, indicating more neointimal tissue growth.
  • The results showed that patients with eruptive CNs experienced a significantly higher target lesion revascularization (TLR) rate both at 1 year (31.3%) and at 5 years (43.8%) compared
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Article Synopsis
  • Neuroendovascular procedures require careful monitoring to prevent complications from unintended device movements, and AI advancements now allow for real-time notifications about these movements.
  • In a study involving nine patients, a real-time AI software was used during coil embolization to provide notifications for key device actions, with promising results in terms of accuracy and safety.
  • The AI system showed high precision and recall in detecting device movements, effectively aiding in the procedure without any reported adverse events, indicating its potential for future use in neuroendovascular therapies.
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Objectives: The efficacy of uncovered self-expandable metal stents (UCSEMS) versus fully covered self-expandable metal stents for distal malignant biliary obstruction remains controversial. Additionally, the heterogeneity of the disease conditions has been indicated in previous studies because pancreatic and non-pancreatic cancers have different characteristics in clinical course. Therefore, the etiology of biliary obstruction necessitates investigations stratified by primary disease.

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Background: Clinical data supporting the target haemoglobin range in patients undergoing peritoneal dialysis (PD) are scarce. This study investigated the association between haemoglobin levels and all-cause mortality in Japanese patients undergoing PD using data from a nationwide dialysis registry.

Methods: A total of 4875 patients aged ≥18 years who were undergoing PD at the end of 2012 were analysed.

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Article Synopsis
  • The article aims to update evidence on the effectiveness and safety of DMARDs for rheumatoid arthritis (RA) to inform the 2024 guidelines by the Japan College of Rheumatology.
  • A thorough search included randomized controlled trials published until June 2022, with independent reviews and meta-analyses conducted on 15 clinical questions related to RA treatment.
  • Key findings indicate that subcutaneous methotrexate is as effective as oral, ozoralizumab with methotrexate is more effective than a placebo, and biosimilars are equally effective as their original counterparts in treating RA.
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