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Efficacy of paclitaxel-based doublet regimens combining with intraperitoneal chemotherapy for advanced gastric cancer with peritoneal metastasis.

Int J Clin Exp Med

January 2016

Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fujian Medical University Teaching HospitalFuzhou, Fujian Province, People's Republic of China; Fujian Key Laboratory of Translational Cancer MedicineFuzhou, Fujian Province, People's Republic of China; Fujian Provincial Key Laboratory of Tumor BiotherapyFuzhou, Fujian Province, People's Republic of China.

We aim to evaluate the efficacy and safety of paclitaxel-based doublet intravenous chemotherapy (IVC) with and without intraperitoneal chemotherapy (IPC) as the first-line treatment in advanced gastric cancer (AGC) with peritoneal metastasis (PM). 173 AGC patients with peritoneal metastasis were enrolled. All patients received paclitaxel-based doublet systemic chemotherapy Among them, 117 patients received IVC+IPC and 56 patients received IVC alone.

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