Effect of sulfonation time on physicochemical, osteogenic, antibacterial properties and biocompatibility of carbon fiber reinforced polyether ether ketone.

The carbon fiber reinforced polyetheretherketone (CFR-PEEK) has been increasingly used in orthopedics dentistry due to its excellent biocompatibility and mechanical properties. However, the biological inertness and poor antibacterial activity limit its clinical applications. This paper focused on the performances of CFR-PEEK with porous morphology that were exposed to different sulfonation periods (1, 3, 5, and 10 min, corresponding to CP-S1, CP-S3, CP-S5, and CP-S10, respectively).

Self-Assembly of Triple-Stranded Lanthanide Molecular Quasi-Lantern Containing 2,2'-Bipyridine Receptor: Luminescence Sensing and Magnetic Property.

Ln-type supramolecular architectures have received significant attention recently due to their unique magnetism and optical properties. Herein, we report the triple-stranded Ln-type lanthanide molecular quasi-lanterns, which are fabricated by the deprotonation self-assembly of a linear ligand featuring a β-diketone chelating claw and 2,2'-bipyridine (bpy) moiety with lanthanide ions (Ln = Eu and Dy). The crystal structure analysis indicates that Eu and Dy ions are all coordinated by eight oxygen donors but in different coordination geometries.

Periodontitis-induced neuroinflammation impacts dendritic spine immaturity and cognitive impairment.

Objective: This study investigated the spinal changes in ligature-induced periodontitis and the role of periodontitis in cognitive impairment.

Methods: Twenty mice were randomized into the control and chronic periodontitis (CP) groups, with the latter receiving ligature-induced periodontitis. Cognitive performance was assessed by fear conditioning test.

Sustainable synthesis of lignin-derived carbon dots with visible pH response for Fe detection and bioimaging.

Synthesis of lignin-based carbon dots (LCDs) with high quantum yield (QY), stable fluorescence properties and biocompatibility has been a challenge. Here, we propose an improved two-step strategy for producing high-quality LCDs from enzymatic hydrolysis lignin (EHL). The p-aminobenzenesulfonic acid used in the strategy not only provides nitrogen and sulfur elements, but also tailors the disordered three-dimensional structure of EHL.

The protective effect of leukemia inhibitory factor on apoptosis of BMSCs induced by hypoxia and serum-deprivation.

Objectives: Bone marrow-derived mesenchymal stem cells (BMSCs) - based tissue engineering is an important strategy for treatment of bone defects. However, the ischemia environment limits the survival and biological functions of BMSCs. The present study aimed to investigate the effect of leukemia inhibitory factor (LIF) on the apoptosis of BMSCs induced by hypoxia and serum-deprivation (H&SD) as well as the underlying pathway mechanism.

Enhanced Electrochemical Performance of a Ti-Cr-Doped LiMnNiO Cathode Material for Lithium-Ion Batteries.

Ti, Cr dual-element-doped LiMnNiO (LNMO) cathode materials (LTNMCO) were synthesized by a simple high-temperature solid-phase method. The obtained LTNMCO shows the standard structure of the 3 space group, and the Ti and Cr doped ions may replace the Ni and Mn sites in LNMO, respectively. The effect of Ti-Cr doping and single-element doping on the structure of LNMO was studied by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM) characteristics.

High throughput miRNA sequencing and bioinformatics analysis identify the mesenchymal cell proliferation and apoptosis related miRNAs during fetal mice palate development.

Background: Palatogenesis requires a precise spatiotemporal regulation of gene expression. Recent studies indicate that microRNAs (miRNAs) are key factors in normal palatogenesis. The present study aimed to explain the regulatory mechanisms of miRNAs during palate development.

Hierarchical subcomponent self-assembly of covalent triple-stranded complexes with 3d-4f vertices: luminescence and magnetic properties.

Well-defined 3d-4f heterometallic supramolecular architectures have attracted attention because of their applications in the field of luminescence and magnetism. However, covalent metallo-supramolecular discrete complexes, decorated with hetero-metallic vertices, have never been reported because of the difficulties in design and control. Herein, we report a series of covalent metallo-supramolecular discrete complexes with 3d-4f vertices synthesized by hierarchical subcomponent self-assembly of tris(2-aminoethyl)amine, 2,6-diformyl--cresol, and lanthanide ions (Ln) with different amines and transition metal ions.

Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer.

Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery. This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers.

Current and prospective therapeutic strategies: tackling and cross-kingdom biofilm.

() is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of () and in the carious lesions especially in children with early childhood caries (ECC) and demonstrates the close interaction between them. During the interaction, both and have evolved a complex network of regulatory mechanisms to boost cariogenic virulence and modulate tolerance upon stress changes in the external environment.

A PdL cage containing Brønsted-base active sites for the one-pot photooxidation/Knoevenagel condensation reaction.

Brønsted-base active sites on a PdL cage facilitates enhanced catalytic efficiency, wide substrate scope and high turnover number (TON) for the one-pot photooxidation/Knoevenagel condensation reaction under mild conditions.

AIEgen-sensitized lanthanide nanocrystals as luminescent probes for intracellular Fe monitoring.

The abnormal Fe level is known to cause various diseases, such as heart failure, liver damage and neurodegeneration. In situ probing Fe in living cells or organisms is highly desired for both biological research and medical diagnostics. Herein, hybrid nanocomposites NaEuF@TCPP were constructed by the assembly of an aggregation-induced emission luminogen (AIEgen) TCPP and NaEuF nanocrystals (NCs).

Dental Bleaching with Phthalocyanine Photosensitizers: Effects on Dentin Color and Collagen Content.

With the increasing demand for tooth bleaching in esthetic dentistry, its safety has been the focus of a comprehensive body of literature. In this context, the aim of the present study was to evaluate the application effects of pentalysine β-carbonylphthalocyanine zinc (ZnPc(Lys))-mediated photodynamic therapy in dentin bleaching and its effects on dentin collagen. We first established a new and reproducible tooth staining model using dentin blocks stained by Orange II and then bleached with ZnPc(Lys) (25 μM) and hydrogen peroxide (10% or 30%).

An Anthracene-Based Bis-Stilbene Derivative as Luminescent Materials for Organic Light Emitting Diodes.

In this work, a new luminescent material of a small-molecule stilbene derivative (BABCz) containing anthracene was designed and synthesized by three simple reactions. The material was characterized by H-NMR, FTMS, and X-ray and tested using TGA, DSC, UV/Vis, fluorescence spectroscopy, and atomic force microscopy. The results demonstrate that BABCz has luminescence properties with good thermal stability and can be doped with 4,4'-bis(N-carbazolyl)-1,1'-biphenyl (CBP) to prepare highly uniform films, which allows the fabrication of OLED devices with ITO/CsCO:BABCz/CBP:BABCz/MoO/Al configuration.

A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate.

Supramolecular assemblies fabricated by peptide-photosensitizer conjugates have attracted increasing attentions in recent years as drug carriers for chemotherapeutics (CTs). However, these assemblies have been known to suffer from disintegration by serum components leading to off-target drug release, and thereby impairing antitumor effects and causing systemic toxicities. To address this problem, this study reports a nano-architectural self-assembly peptide-photosensitizer carrier (NSPC) fabricated by conjugating a phthalocyanine derivative (MCPZnPc) and ε-poly-l-lysine (EPL).

Neuromuscular and occlusion analysis to evaluate the efficacy of three splints on patients with bruxism.

Objective: Occlusal splints are always applied on individuals with bruxism to reduce tooth wear and relieve orofacial symptoms such as myofascial pain. The stomatognathic system is mainly composed of tooth, occlusion, masticatory muscles, and temporomandibular joint. The occlusion and masticatory muscles function are regarded as the important parameters for evaluating the stomatognathic system state objectively.

Mussel-inspired HA@TA-CS/SA biomimetic 3D printed scaffolds with antibacterial activity for bone repair.

Bacterial infection is a major challenge that could threaten the patient's life in repairing bone defects with implant materials. Developing functional scaffolds with an intelligent antibacterial function that can be used for bone repair is very important. We constructed a drug delivery (HA@TA-CS/SA) scaffold with curcumin-loaded dendritic mesoporous organic silica nanoparticles (DMON@Cur) via 3D printing for antibacterial bone repair.

Exfoliation of a Two-Dimensional Metal-Organic Framework for Enhanced Photocatalytic CO Reduction.

A two-dimensional metal-organic framework, FICN-12, was constructed from tris[4-(1-pyrazole-4-yl)phenyl]amine (HTPPA) ligands and Ni secondary building units. The triphenylamine moiety in the HTPPA ligand readily absorbs UV-visible photons and sensitizes the Ni center to drive photocatalytic CO reduction. FICN-12 can be exfoliated into monolayer and few-layer nanosheets with a "top-down" approach, which exposes more catalytic sites and increases its catalytic activity.

System to screen and purify active ingredients from herbal medicines using hydrogel-modified human umbilical vein endothelial cell membrane chromatography coupled with semi-preparative high-performance liquid chromatography-offline-high-performance liquid chromatography-mass spectrometry.

Analytical screening and validation systems based on a combination of cell membrane chromatography and two-dimensional chromatography-tandem mass spectrometry are incapable of providing prepared samples containing the active ingredients found in traditional Chinese medicine; therefore, these samples cannot be directly used in subsequent studies. In this study, a semi-preparative cell membrane chromatography column was developed using a hydrogel-modified carrier and human umbilical vein endothelial cells to optimize prepared conditions, such as hydrogel polymerization, cell fragmentation, and cell membrane volume. This increased the binding ratio of membrane protein and carrier to 15.

A metal-organic framework-supported dinuclear iron catalyst for hydroboration of carbonyl compounds.

Preparation of catalytically active dinuclear transition metal complexes with an open coordination sphere is a challenging task because the metal sites tend to be "saturated" with excess donor atoms around during synthesis. By isolating the binding scaffolds with the metal-organic framework (MOF) skeleton and installing metal sites through post-synthetic modification, we succeed in constructing a MOF-supported metal catalyst, namely FICN-7-Fe2, with dinuclear Fe sites. FICN-7-Fe2 effectively catalyses the hydroboration of a broad range of ketone, aldehyde, and imine substrates with a low loading of 0.

Disruption of hedgehog signaling leads to hyoid bone dysplasia during embryogenesis.

The development of the hyoid bone is a complex process that involves the coordination of multiple signaling pathways. Previous studies have demonstrated that disruption of the hedgehog pathway in mice results in a series of structural malformations. However, the specific role and critical period of the hedgehog pathway in the early development of the hyoid bone have not been thoroughly characterized.

Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?

Objectives: To evaluate the effects of matrix metalloproteinase (MMP) and cathepsin K (catK) inhibitors on resistance to dentin erosion.

Methodology: A total of 96 dentin specimens (3×3×2 mm) were prepared and randomly assigned into four groups (n=24): deionized water (DW); 1 µM odanacatib (ODN, catK inhibitor); 1 mM 1,10-phenanthroline (PHEN, MMP inhibitor); and 1 µM odanacatib + 1 mM 1,10-phenanthroline (COM). Each group was further divided into two subgroups for the application of treatment solutions before (PRE) and after erosive challenges (POST).

A combined theoretical and experimental investigation on the photocatalytic hydrogenation of CO on Cu/ZnO polar surface.

The photocatalytic hydrogenation of CO by Cu-deposited ZnO (Cu/ZnO) polar surfaces is investigated through density functional theory (DFT) calculations combined with experimental work. The DFT results demonstrate that, without Cu-loading, CO and H present weak physisorption on the clean ZnO polar surface, except that H undergoes strong chemisorption on the ZnO(0001̄) surface. Cu deposition on the ZnO polar surface could remarkably enhance the CO chemisorption ability, due to the induced charge redistribution on the interface of the Cu/ZnO polar surface systems.