An easily achievable strategy to promote the penetration of methylene blue into dentinal tubules.

Background: One critical issue that impairs the therapeutic effects of antimicrobial photodynamic therapy (aPDT) in root canal disinfection is the insufficient penetration of photosensitizer into dentinal tubules. Therefore, this study aimed to compare the treatments in enhancing photosensitizers' penetrability for aPDT in root canal therapy.

Methods: Thirty premolars with a single root canal were randomly divided into three groups (n = 10), using Methylene blue (MB) as a photosensitizer and treated with different approaches: sonic-assisted diffusing group, ultrasonic-assisted diffusing group and the control without treatment.

Multifunctional Mesoporous Silica Nanoparticles Reinforced Silk Fibroin Composite with Antibacterial and Osteogenic Effects for Infectious Bone Rehabilitation.

Background: Existing implant materials cannot meet the essential multifunctional requirements of repairing infected bone defects, such as antibacterial and osteogenesis abilities. A promising strategy to develop a versatile biomimicry composite of the natural bone structure may be accomplished by combining a multifunctional nanoparticle with an organic scaffold.

Methods: In this study, a quaternary ammonium silane-modified mesoporous silica containing nano silver (Ag@QHMS) was successfully synthesized and further combined with silk fibroin (SF) to fabricate the multifunctional nano-reinforced scaffold (SF-Ag@QHMS) using the freeze-drying method.

Boredom Proneness and Online Deviant Behaviors: The Mediating Role of Rumination and the Moderating Role of Gender.

Online deviant behaviors have received increasing attention. This study examined the association between boredom proneness and online deviant behaviors as well as the mediating role of rumination and the moderating role of gender in the relationship. A sample of 1001 college students (Mage = 20.

Computational mining of endohedral C electrides: tri-metal alkali and alkaline-earth encapsulation.

C is the second most abundant fullerene next to C. In this work, the exploration of C based electrides is proposed by theoretical encapsulation of group I/II trimetallic clusters into the C cage. Herein, we provide computational evidence that endohedral metallofullerenes M@C (M = Li, Na, K, Be, Mg, Ca, Sr, Ba) can exist stably by calculating encapsulation energies and analyzing atom centered density matrix propagation molecular dynamics simulations.

How do MNEs shape their international strategic alliances to facilitate higher alliance performance? Absorptive capacity as an antecedent.

The international strategic alliance in international marketing is international social network to realize superior performance. This requires firms to increasingly consolidate international relationship with foreign partners. Knowledge acquisition and integration by absorptive capacity (AC) as an antecedent for international strategic alliance is understudied.

MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response.

Background/purpose: Recent studies have pointed to the crucial role of microRNAs (miRNAs) in chronic periodontitis (CP). This study investigated the regulation and potential mechanisms of miR-28-5p in CP patients and lipopolysaccharide (LPS)-induced periodontal ligament cells (PDLCs).

Materials And Methods: 76 CP patients and 71 periodontally healthy subjects were included.

Effects of the application timing of anti-erosive agents on dentin erosion.

This in vitro study aimed to evaluate the effects of the application timing of anti-erosive agents on dentin erosion. Eighty dentin specimens with dimensions of 2 × 2 × 2 mm were prepared and randomly divided into 4 groups based on the treatment solutions: 1.23 × 10 μg/ml sodium fluoride (NaF), 120 μg/ml chlorhexidine (CHX), 300 μg/ml quercetin (QUE), and deionized water (DW, negative control).

[Research progress of polyetheretherketone and its composites in the field of dental implant].

Polyetheretherketone (PEEK) is a polymer material composed of aromatic rings connected by ether and ketone groups. It has advantages of excellent biocompatibility, stable chemical properties, and appropriate elasticity modulus. Since PEEK are increasingly used in dentistry in recent years, the properties, modification methods, and research advances of them in oral implantology were discussed in this review.

Clinical efficacy of highly agglutinative staphylococcin combined with neoadjuvant chemotherapy on patients with intermediate or advanced oral cancer.

Objectives: To evaluate the clinical efficacy of highly agglutinative staphylococcin combined with neoadjuvant chemotherapy on patients with intermediate or advanced oral cancer.

Methods: A total of 80 patients with intermediate or advanced oral cancer treated in Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from January 2020 to January 2022 were included. Patients were divided into two groups based on their treatment choice, with 40 cases in each group.

Antimicrobial Photodynamic Effect of Cross-Kingdom Microorganisms with Toluidine Blue O and Potassium Iodide.

() and () are prominent microbes associated with rapid and aggressive caries. In the present study, we investigated the antimicrobial efficacy, cytotoxicity, and mechanism of toluidine blue O (TBO)-mediated antimicrobial photodynamic therapy (aPDT) and potassium iodide (KI). The dependence of KI concentration, TBO concentration and light dose on the antimicrobial effect of aPDT plus KI was determined.

Gut microbiota may mediate the impact of chronic apical periodontitis on atherosclerosis in apolipoprotein E-deficient mice.

Aim: There are growing evidences linking chronic apical periodontitis (CAP) to atherosclerosis. Gut microbiota is found to be involved in the development of atherosclerosis. Recent studies have shown that CAP could change the diversity and composition of the gut microbiota.

An agaric-like covalent organic framework composite for efficient extraction of trace cytokinins in plant samples.

Covalent organic framework composites have received great interest and regarded as new-generation porous materials in application of sample preparation. In this work, an agaric-like graphene oxide @ covalent organic framework (AGO@COF) composite was first synthesized and used as an ideal adsorbent for enrichment of trace cytokinins (CKs) due to its large specific surface area, rich in micro-mesopore and organic functional groups. The contact areas between AGO@COF composite and CKs were greatly increased due to the special agaric-like morphology, which would further improve the extraction efficiency.

Dual function of quercetin as an MMP inhibitor and crosslinker in preventing dentin erosion and abrasion: An in situ/in vivo study.

Objective: The aim of the present study was to evaluate the in situ/in vivo effect of quercetin on dentin erosion and abrasion.

Methods: Human dentin blocks (2 × 2 × 2 mm) were embedded and assigned to 6 groups: 75 μg/mL, 150 μg/mL and 300 μg/mL quercetin (Q75, Q150, Q300); 120 μg/mL chlorhexidine (CHX, positive control); and deionized water and ethanol (the negative controls). The specimens were treated with the respective solutions for 2 min and then subjected to in situ/in vivo erosive/abrasive challenge for 7 d as follows: in vivo erosion 4 times a day and then in vivo toothbrush abrasion after the first and last erosive challenges of each day.

Mitochondria-Targeting Boron Dipyrromethene Based Photosensitizers for Enhanced Photodynamic Therapy: Synthesis, Optical Properties, and in vitro Biological Activity.

Increasing Investigations show that photosensitizers (PSs) which target mitochondria are useful for enhancing photodynamic therapy (PDT) efficacy. Herein, we carefully designed and synthesized four triphenylphosphonium (TPP)-modified boron dipyrromethene (BDP)-based PSs through Cu(I)-assisted "3+2" cycloaddition reaction. All of them exhibit intense red light absorption with maxima between 659 and 663 nm, considerable fluorescence emission with quantum yields of 0.

CircPUM1 Knockdown Confers Radiosensitivity in Oral Squamous Cell Carcinoma by Regulating the miR-580/STAT3 Pathway.

CircPUM1 acts as an oncogene in a variety of tumors, and there is no related research on oral squamous cell carcinoma. This study aimed to evaluate the clinical significance of CircPUM1 in oral squamous cell carcinoma radiotherapy. Radio-resistant cell lines were established by increasing the X-ray dose.

Site-specific water dynamics in the first hydration layer of an anti-freeze glyco-protein: a simulation study.

Antifreeze glycoproteins (AFGPs) inhibit ice recrystallization by a mechanism remaining largely elusive. The dynamics of AFGPs' hydration water and its involvement in the antifreeze activity, for instance, have not been identified conclusively. We herein, by simulation and theory, examined the picosecond site-specific water dynamics in the first hydration layer of a solvated AFGP8.

TVGG Dental Implant Identification System.

Identifying the right accessories for installing the dental implant is a vital element that impacts the sustainability and the reliability of the dental prosthesis when the medical case of a patient is not comprehensive. Dentists need to identify the implant manufacturer from the x-ray image to determine further treatment procedures. Identifying the manufacturer is a high-pressure task under the scaling volume of patients pending in the queue for treatment.

A novel visible light-curing chitosan-based hydrogel membrane for guided tissue regeneration.

Inflammation and trauma destroy the tooth-supporting tissue, leading to the loss of oral function and the difficulty of denture restoration. Guided tissue regeneration (GTR) is a technique based on a barrier membrane designed to restrict soft tissue invasion and maintain the space for bone regeneration. This study examined a new formulation to prepare methacrylated carboxymethyl chitosan (CMCS-MA) hydrogel as a barrier membrane that could be crosslinked under visible-light irradiation.

Effects of protease inhibitors on dentin erosion: an in situ study.

Objective: This in situ study aimed to evaluate the effects of the inhibitors of matrix metalloproteinases (MMPs) and cysteine cathepsins on dentin erosion.

Materials And Methods: Ten volunteers participated in this study. Each volunteer wore an intraoral appliance containing 4 dentin specimens subjected to different treatments: deionized water as a control, 1 mM 1,10-phenanthroline (an MMP inhibitor), 50 µM E-64 (a cysteine cathepsin inhibitor), and 1 mM 1,10-phenanthroline + 50 µM E-64.

D-alanylation of lipoteichoic acid contributes to biofilm formation and acidogenesis capacity of Streptococcusmutans.

Background: D-alanylation of Lipoteichoic acid (LTA) is considered to be essential for virulence factors expression in Gram-positive microorganism. The effects of the D-alanylation of LTA on biofilm formation and acidogenesis of Streptococcus mutans (S. mutans) are still not clearly understood.