Photo-induced copper-catalyzed alkynylation and amination of remote unactivated C(sp)-H bonds.

A method for remote radical C-H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,-hydrogen atom transfer. Unactivated secondary and tertiary C-H bonds at β, γ, and δ positions can be functionalized in a predictable manner.

Minimally invasive follicular thyroid carcinoma mimicking pituitary adenoma: a case report.

The metastasis of cancer to the pituitary gland is uncommon but may mimic a typical pituitary adenoma. Such cancers often derive from the breasts or the lungs, or very rarely from thyroid carcinoma. We described the case of a 60-year-old woman who presented with headaches and pain to the right eye.

Chidamide, a novel histone deacetylase inhibitor, inhibits multiple myeloma cells proliferation through succinate dehydrogenase subunit A.

Most patients with multiple myeloma (MM) would finally relapse despite the fact that initial MM may turn to remission by conventional chemotherapy. Current chemotherapy regimens have limited effect on relapse MM patients. As a new histone deacetylase inhibitor, chidamide has been used in malignancy treatment.

Coexistence of multiple rare spinal abnormalities in type 1 neurofibromatosis: a case report and literature review.

Orthopaedic involvement is the most common clinical presentation of Neurofibromatosis type 1 (NF-1) patients with the spinal abnormalities more frequently affected. In the spinal deformities of NF-1 patients, despite the scoliosis is the most frequent finding, several distinctive radiographic features, such as dural ectasia, defective pedicles, and spondylolisthesis, are relatively less common. Here, we reported a 16-year-old boy diagnosed with NF-1 who presented with dural ectasia, defective pedicles, and spondylolisthesis concomitantly, described the surgical treatment and provided a literature review.