[A survey on the time to reach full enteral feeding for preterm infants with gestational age <32 weeks in neonatal intensive care units of Chinese Neonatal Network].

To analyze the time to reach full enteral feedings (TFEF) among preterm infants with gestational age (GA)<32 weeks admitted to the neonatal intensive care units (NICU) of Chinese Neonatal Network (CHNN). This was a retrospective analysis based on the database from the CHNN 89 participating centers between January 1, 2019 and December 31, 2022. All 16 155 preterm infants with a GA <32 weeks and a birth weight <1 500 g, admitted to the NICU within 24 h after birth, hospitalization for at least 7 d and achieved full enteral feedings before discharge were included.

Pragmatic, multicentre, randomised controlled trial of a Hospital-Community-Home Tiered Transitional Care (HCH-TTC) programme for individuals with type 2 diabetes: a study protocol.

Introduction: Type 2 Diabetes Mellitus (T2DM) and its complications significantly increase the risk of premature mortality and disability among patients, placing a considerable burden on socioeconomic development. Evidence has shows that effective transitional care can improve health outcomes for patients with T2DM. However, T2DM transitional care faces challenges including service discontinuity, communication breakdowns and a lack of personalised design, leading to potential issues of undertreatment and overtreatment, increasing the risk of improper blood sugar management.

Functional Magnetic Resonance Imaging in Prurigo Nodularis: A Systematic Review.

Prurigo nodularis (PN) is a chronic pruritic inflammatory skin condition characterized by nodular skin lesions in a typical distribution pattern caused by various dermatological and/or non-dermatological conditions. In recent years, significant advances have been made in the understanding of the cutaneous pathophysiology of PN resulting in novel treatment options such as Interleukin-4, -13, -17, -31- or Januskinase inhibitors. However, many aspects of the neurophysiology are largely unknown, including the processing in the central structural and functional network involved in PN.

Pentose Phosphate Recycling driven by Gli1 contributes to chemotherapy resistance in Cancer Cells.

The Hedgehog Signaling Pathway plays an important role in cancer development and chemotherapy resistance. However, whether the pathway functions depend on the metabolic reprogramming of cancer cells has not been well studied. In this study, we found that the expression level of Gli1, a key transcription factor downstream of the Hedgehog Signaling Pathway, is significantly increased in patients with pancreatic cancer resistant to gemcitabine neoadjuvant chemotherapy.

Adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and trajectories of depressive symptomatology in youth.

Background: The rising prevalence of youth depression underscores the need to identify modifiable factors for prevention and intervention. This study aims to investigate the protective role of Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on depressive symptoms in adolescents.

Methods: Participants were identified from the Adolescent Brain Cognitive Development study.

Combined exposure of sleep deprivation and environmental particulate matter drives aging in multiple systems.

Sleep disturbance accelerates aging, with accompanying exposure to air pollution. However, most studies ignore the combined exposure. This study aimed to investigate the combined effects of sleep deprivation and PM exposure on multi-system aging and to explore the damage mechanisms.

Synthesis and biological evaluation of the Fluoro analog of Romidepsin with improved selectivity for class I histone deacetylases (HDACs).

Selective inhibition of Class I HDACs has emerged as a promising approach for cancer therapy. Building on our previous work with Largazole (a member of the natural depsipeptide family), we have applied a similar fluorination modification to Romidepsin and synthesized its fluoro analog (12) in 12 steps. This analog exhibits potent inhibitory activity against Class I HDACs but shows no inhibitory effect on HDAC6, confirming its selectivity as a Class I HDAC inhibitor (IC50 HDAC1 0.

Trajectories and predictors of financial toxicity in breast cancer patients: A multicenter longitudinal study in China.

Background: Patients with breast cancer experience varying levels of financial toxicity (FT), but the factors contributing to sustained financial toxicity remain poorly understood.

Methods: This longitudinal study was conducted from November 2022 to March 2024 in China. Participants were recruited from four Tertiary Level A hospitals using convenient sampling.

An MR-only deep learning inference model-based dose estimation algorithm for MR-guided adaptive radiation therapy.

Background: Magnetic resonance-guided adaptive radiation therapy (MRgART) systems combine Magnetic resonance imaging (MRI) technology with linear accelerators (LINAC) to enhance the precision and efficacy of cancer treatment. These systems enable real-time adjustments of treatment plans based on the latest patient anatomy, creating an urgent need for accurate and rapid dose calculation algorithms. Traditional CT-based dose calculations and ray-tracing (RT) processes are time-consuming and may not be feasible for the online adaptive workflow required in MRgART.

Exploring the neural mechanisms linking healthy aging and cognitive maintenance: insights from Mendelian randomization and mediation analyses.

As global population ages, maintaining cognitive health in elderly is crucial. Previous studies suggest a positive link between healthy aging and cognition, but the neural mechanisms remain unclear. This study used genome-wide association studydata to investigate neural mechanisms between healthy aging and cognition.

Antagonist Targeting the Species-Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti-H. pylori Infection.

Helicobacter pylori (H. pylori) is a group-1 definite pathogenic carcinogen that infects approximately half of the global population, yet no species-specific chemotherapy has yet been developed. It is previously discovered that H.

PLZF-expressing CD4 T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling.

Background: Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4 tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of asthma. Furthermore, promyelocytic leukemia zinc finger (PLZF) is an essential transcription factor involved in asthmatic tolerance and has been implicated in the regulation of CD4CD44 memory T cells.

Survival benefit of surgery vs radiotherapy alone to patients with stage IA lung adenocarcinoma: a propensity score-matched analysis.

Objectives: We compared the overall survival (OS) and cancer-specific survival (CSS) of patients who received radiotherapy and surgery, respectively, in a large population.

Methods: In this study, we counted the patients diagnosed with stage IA lung adenocarcinoma in the SEER database from 2015 to 2019. We compared the overall survival (OS) and cancer-specific survival (CSS) through Kaplan Meier analysis, balanced the differences of primary data through propensity score matching (PSM), screened independent prognostic factors through Cox regression analysis, and then compared the survival differences of different treatment methods through hierarchical analysis.

Maternal di(2-ethylhexyl) phthalate exposure increases the risk of congenital heart disease in mice offspring.

Abstrct: BACKGROUD: Epidemiological data suggest that maternal occupational exposure to mixed phthalates comprising di(2-ethylhexyl) phthalate (DEHP) increases the risk of congenital heart disease (CHD). In this study, we used mice as an animal model to validate impact of first-trimester DEHP exposure on the risk of CHD in offspring, to elucidate the possible mechanisms and to provide a potential feasible intervention.

Methods And Results: Eight-week-old C57BL/6J pregnant mice were randomly divided into standard and DEHP diet groups.

Uncovering the genetic variation spectrum of colorectal polyposis from a multicentre cohort in China.

This multicentre study addresses the genetic spectrum of colorectal polyposis in China. We analyzed 120 patients with over 10 adenomas using a 139-gene next-generation sequencing panel and multiplex ligation-dependent probe amplification. Findings revealed that 89 patients carried pathogenic germline variants, primarily in the APC gene.

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation.

In Parkinson's Disease (PD), elevated serum lysophosphatidylcholine (LPC) levels correlate with disease progression. However, the mechanisms by which abnormal LPC elevation contributes to PD-related neurotoxicity remain poorly understood. This study aims to investigate the pathogenic role of LPC in dopaminergic neuronal damage and elucidates its underlying mechanisms.

METTL3-mA-mediated TGF-β signaling promotes Fuchs endothelial corneal dystrophy via regulating corneal endothelial-to-mesenchymal transition.

Fuchs endothelial corneal dystrophy (FECD) is the leading cause of vision-threatening corneal endothelial dystrophy without pharmacologic treatments. Corneal endothelial-mesenchymal transition (cEndMT), a specific cellular phenotypic transition, is implicated in the vicious cycle in FECD pathogenesis. Here, we investigated the reversible epigenetic regulation of N-methyladenosine (mA) during cEndMT process and FECD progression.

Efficacy of 5-aminolevulinic acid photodynamic therapy for Olsen Grade 3 actinic keratosis: A prospective cohort study.

Background: Actinic keratosis (AK) is a common cutaneous keratinocyte dysplasia categorized by Olsen Grade (OG) 1-3. OG 3 AK, which has a higher risk of progressing to cutaneous squamous cell carcinoma (cSCC), presents treatment challenges. While 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is effective for non-hyperkeratotic AK (OG 1-2), its efficacy for OG 3 AK remains debated.

PRC1 promotes ovarian cancer progression by binding to RPL4 and increasing MDM2-mediated p53 ubiquitination.

Ovarian cancer (OC) is one of the most fatal gynecological carcinomas, causing significant detriment to women's health. Protein regulator of cytokinesis 1 (PRC1) is a microtubule-associated protein that is found to be highly expressed in many different cancers. Despite this, the exact way in which PRC1 stimulates the growth of OC has yet to be completely understood.

CXCR4-Targeted Ultrasound Microbubbles for Imaging and Enhanced Chemotherapy/Immunotherapy in Liver Cancer.

Ultrasound molecular imaging is an innovative imaging modality that combines ultrasound with molecular probes to observe live biological processes at the cellular and molecular levels. C-X-C chemokine receptor type 4 (CXCR4) is a specific target in liver tumors and plays a crucial role in promoting tumor growth, invasion, metastasis, and angiogenesis. This study pioneered the use of CXCR4-targeted ultrasound molecular imaging for visualized antitumor therapy and investigated the potential of CXCR4-targeted microbubbles (MBs) in sensitizing liver tumor treatment.

Reevaluating the Role of Pou3f1 in Striatal Development: Evidence from Transgenic Mouse Models.

The striatum, a critical component of the basal ganglia, is essential for motor control, cognitive processing, and emotional regulation. Medium spiny neurons (MSNs) are the primary neuronal population in the striatum, classified into D1 and D2 subtypes. The transcription factor Pou3f1 has been hypothesized to play a crucial role in the development of pyramidal neurons.

Molecular mechanisms by which polyethylene terephthalate (PET) microplastic and PET leachate promote the growth of benthic cyanobacteria.

Toxic blooms of benthic cyanobacteria greatly threaten freshwater ecological health and drinking water safety. Meanwhile, microplastic pollution is becoming increasingly severe and microplastics accumulate in large quantities at the bottom of lakes and rivers, widely coexisting with algae. However, impacts of microplastics on benthic cyanobacteria are still unknown.

From patterns to pathways: Latent class trajectories of self-perceptions of aging and their causal effects on multi-state functional transitions.

Objectives: This study examines the heterogeneous developmental trajectories of self-perceptions of aging (SPA) and their causal effects on functional health transitions in older adults. Specifically, we aim to identify latent classes of SPA development, assess their impact on multi-state functional transitions, and quantify the loss in healthy life expectancy attributable to negative SPA.

Methods: Drawing from the Chinese Longitudinal Healthy Longevity Survey (2008-2018; n = 14,020), we implemented latent class trajectory modeling to identify SPA developmental patterns.