47 results match your criteria: "From the University of Ottawa[Affiliation]"
2024 Canadian Surgery Forum: Sept. 25-28, 2024.
Can J Surg
November 2024
From St. Michael's Hospital (Naveed, Deshpande, Gomez, Rezende-Neto, Ahmed, Beckett), and the University of Toronto (Naveed).
Triage Decision-Making in Interdisciplinary Pediatric Chronic Pain Programs.
Pain Manag Nurs
April 2024
From the University of Ottawa, School of Nursing; Chronic Pain Services at The Children's Hospital of Eastern Ontario, Ottawa, Canada.
Article Synopsis
- - Interdisciplinary pediatric chronic pain programs are essential for treating complex youth with chronic pain, but nurses currently lack evidence-based support to guide their triage decisions, leading to potentially inefficient outcomes.
- - A qualitative study involving 12 nurses from different programs explored their decision-making practices and identified key themes: determinants influencing triage, the triage decision-making process, and external factors affecting these decisions.
- - The results underscore the complexity of nursing roles in triage and highlight the nurses' interest in implementing an evidence-based clinical decision support tool to improve the triage process and prioritize patients in need of interdisciplinary care.
Patient Engagement in a Multi-Stakeholder Workshop to Plan the Collection of Patient-Oriented Outcomes for Children with Inherited Metabolic Diseases.
Healthc Q
April 2022
Leads a research program that aims to generate evidence to improve health outcomes and experiences with care for children with rare diseases and their families. Beth can be contacted by e-mail at
Building on a study to develop core outcome sets for children with rare inherited metabolic diseases, the purpose of this workshop was to inform the design of longitudinal pediatric registries that support registry-based clinical trials. This workshop was co-designed by two patient/family partner investigators and attended by two family advisors who received preparatory training. Patient partners and advisors recommended integrating the collection of registry data into everyday life and highlighted the importance of transparent communication and attention to the issue of integration of patient-reported data into clinical care.
View Article and Find Full Text PDFSecond-Order Peer Reviews of Clinically Relevant Articles for the Physiatrist: Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial.
Am J Phys Med Rehabil
August 2022
From the University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada (SKOB); The Ottawa Hospital, Ottawa, Ontario, Canada (AEC); and University Health Network Toronto Rehabilitation Institute, Toronto, Ontario, Canada (JFF).
MG-BERT: leveraging unsupervised atomic representation learning for molecular property prediction.
Brief Bioinform
November 2021
Xiangya School of Pharmaceutical Sciences, Central South University, China.
Article Synopsis
- Accurately predicting molecular properties is crucial for drug design, but traditional methods need extensive expertise and often struggle with insufficient labeled data.
- Researchers developed a new model called molecular graph BERT (MG-BERT) that combines graph neural networks with BERT to learn from molecular graphs effectively.
- MG-BERT uses a self-supervised strategy for pretraining on unlabeled data, allowing it to excel in predicting molecular properties and outperform existing methods while providing high interpretability without needing custom-made features.
The management of occult hemothorax in adults with thoracic trauma: A systematic review and meta-analysis.
J Trauma Acute Care Surg
December 2020
From the University of Ottawa (R.W.G., A.M.F., L.P., A.T.); and Trauma Services, Division of General Surgery (R.W.G., A.M.F., A.T., J.L.), Department of Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
Background: Hemothorax is a common sequelae following thoracic trauma and is associated with significant morbidity and mortality. Current guidelines recommend all traumatic hemothoraces be considered for drainage with tube thoracostomy (TT), regardless of size. With increasing use of computed tomography, smaller hemothoraces not seen on x-ray (defined as an occult hemothorax) are frequently detected.
View Article and Find Full Text PDFmicroRNA-128: A New Tool in the Smooth Muscle Cell Plasticity Toolbox.
Circ Res
June 2020
From the University of Ottawa Heart Institute, Canada; and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Canada.
Loss of MLKL (Mixed Lineage Kinase Domain-Like Protein) Decreases Necrotic Core but Increases Macrophage Lipid Accumulation in Atherosclerosis.
Arterioscler Thromb Vasc Biol
May 2020
From the University of Ottawa Heart Institute, ON, Canada (A.R., S.R., M.-A.N., M.G., H.W., M.L.C., T.D., A.P., T.A.L., M.O., K.J.R.).
Objectives: During the advancement of atherosclerosis, plaque cellularity is governed by the influx of monocyte-derived macrophages and their turnover via apoptotic and nonapoptotic forms of cell death. Previous reports have demonstrated that programmed necrosis, or necroptosis, of plaque macrophages contribute to necrotic core formation. Knockdown or inhibition of the necrosome components RIPK1 (receptor-interacting protein kinase 1) and RIPK3 (receptor-interacting protein kinase 3) slow atherogenesis, and activation of the terminal step of necroptosis, MLKL (mixed lineage kinase domain-like protein), has been demonstrated in advanced human atherosclerotic plaques.
View Article and Find Full Text PDFLeading the Long Noncoding RNA Pack: PELATON in Human Atherosclerosis.
Arterioscler Thromb Vasc Biol
March 2020
Metabolic Regulators of Vascular Inflammation.
Arterioscler Thromb Vasc Biol
February 2020
From the University of Ottawa Heart Institute, Ottawa, ON, Canada; and the Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ON, Canada.
A systematic review and meta-analysis evaluating geriatric consultation on older trauma patients.
J Trauma Acute Care Surg
March 2020
From the University of Ottawa (D.E., B.G., L.K.); Clinical Epidemiology Program (W.C.), Ottawa Hospital Research Institute; Epidemiology Program, The Ottawa Hospital (D.E., J.M., S.F., J.L.); and University of Ottawa Library (K.F.), Ottawa, Ontario, Canada.
Background: Early involvement of geriatrics is recommended for older trauma patients.
Objective: This systematic review aimed to determine the impact of a geriatric assessment on mortality, hospital length of stay, discharge destination, and delirium incidence in patients 65 years and older admitted to a trauma center.
Methods: The protocol was developed according to Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and registered in PROSPERO (CRD42019131870).
Current Smoking Is Increased in Axial Psoriatic Arthritis and Radiographic Sacroiliitis.
J Rheumatol
December 2019
From the University of Ottawa Faculty of Medicine, Rheumatology, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University Hospital, Ankara, Turkey; Unit of Rheumatology, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy; Ege University, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey; Suleyman Demirel University, Department of Internal Medicine, Division of Rheumatology, Isparta, Turkey; Uludag University, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey; Mustafa Kemal University, Department of Internal Medicine, Division of Rheumatology, Hatay, Turkey; Diskapi Yildirim Beyazit Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey; Kahramanmaras Sutcu Imam University, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey; Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey; Marmara University, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey; Selcuk University, Department of Internal Medicine, Division of Rheumatology, Konya, Turkey. D. Solmaz had funding from Union ChimiqueBelge (UCB) for an axial spondyloarthritis fellowship. S. Bakirci had funding from the Turkish Society for Rheumatology (TRD). S.Z. Aydin received honoraria from Abbvie, Celgene, UCB, Novartis, Jannsen, and Sanofi. D. Solmaz, MD, University of Ottawa Faculty of Medicine, Rheumatology; U. Kalyoncu, MD, Associate Professor, Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology; I. Tinazzi, MD, Unit of Rheumatology, Sacro Cuore-Don Calabria Hospital; S. Bakirci, MD, University of Ottawa Faculty of Medicine, Rheumatology; O. Bayindir, MD, Ege University, Department of Internal Medicine, Division of Rheumatology; A. Dogru, MD, Suleyman Demirel University, Department of Internal Medicine, Division of Rheumatology; E. Dalkilic, MD, Associate Professor, Uludag University, Department of Internal Medicine, Division of Rheumatology; G. Kimyon, MD, Mustafa Kemal University, Department of Internal Medicine, Division of Rheumatology; C. Ozisler, MD, Diskapi Yildirim Beyazit Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology; G.Y. Cetin, MD, Associate Professor, Kahramanmaras Sutcu Imam University, Department of Internal Medicine, Division of Rheumatology; L. Kilic, MD, Hacettepe University, Department of Internal Medicine, Division of Rheumatology, Hacettepe University Hospital; A. Omma, MD, Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology; M. Can, MD, Associate Professor, Marmara University, Department of Internal Medicine, Division of Rheumatology; S. Yilmaz, MD, Professor, Selcuk University, Department of Internal Medicine, Division of Rheumatology; A. Erden, MD, Hacettepe University, Department of Internal Medicine, Division of Rheumatology; S.Z. Aydin, MD, Associate Professor, University of Ottawa Faculty of Medicine, Ottawa Hospital Research Institute. Address correspondence to Dr. S.Z. Aydin, 1967 Riverside Drive, Ottawa, Ontario K1H 7W9, Canada. E-mail: Accepted for publication November 13, 2019.
Objective: The effect of smoking in psoriatic arthritis (PsA) is under debate. Our aim was to test whether smoking is increased in axial PsA (axPsA).
Methods: Included in the analysis were 1535 patients from PsArt-ID (PsA-International Database).
The Relationship Between Physical Examination and Ultrasonography of Large Entheses of the Achilles Tendon and Patellar Tendon Origin.
J Rheumatol
July 2020
From the University of Ottawa Faculty of Medicine, Ottawa Hospital Research Institute, Department of Internal Medicine, Division of Rheumatology, Ottawa, Ontario, Canada; Istanbul Medeniyet University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey; Complejo Hospitalario Torrecárdenas, Department of Internal Medicine, Division of Rheumatology, Almería, Spain; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; University of California, Department of Statistics, Riverside, California, USA; University of Toronto, Department of Internal Medicine, Division of Rheumatology, Krembil Research Institute, Toronto Western Hospital; University of Toronto, Women's College Research Institute, Women's College Hospital, Rheumatology, Toronto, Ontario, Canada.
Objective: To investigate the relationship between physical examination (PE) and sonographic features of enthesitis, based on anatomical sites.
Methods: The analysis was done using merged raw data of 3 studies on 2298 entheses.
Results: Patients with clinical Achilles enthesitis had more abnormalities on ultrasound (US): hypoechogenicity, p < 0.
Consensus Building in OMERACT: Recommendations for Use of the Delphi for Core Outcome Set Development.
J Rheumatol
August 2019
From the University of Ottawa, Departments of Medicine and Innovation in Medical Education; Center for Global Health, University of Ottawa; Division of Rheumatology, Department of Medicine, School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Centre for Practice-Changing Research, Ottawa Hospital Research Institute; OMERACT, Ottawa; Institute for Work and Health, Toronto, Ontario; Department of Medicine, McGill University, Montreal, Quebec, Canada; University of Liverpool, Department of Biostatistics, COMET, Liverpool, UK; Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Sydney Medical School, University of Sydney, Sydney; Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health; Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam, the Netherlands.
Objective: Developing international consensus on outcome measures for clinical trials is challenging. The following paper will review consensus building in Outcome Measures in Rheumatology (OMERACT), with a focus on the Delphi.
Methods: Based on the literature and feedback from delegates at OMERACT 2018, a set of recommendations is provided in the form of the OMERACT Delphi Consensus Checklist.
Renal and adrenal masses containing fat at MRI: Proposed nomenclature by the society of abdominal radiology disease-focused panel on renal cell carcinoma.
J Magn Reson Imaging
April 2019
Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
This article proposes a consensus nomenclature for fat-containing renal and adrenal masses at MRI to reduce variability, improve understanding, and enhance communication when describing imaging findings. The MRI appearance of "macroscopic fat" occurs due to a sufficient number of aggregated adipocytes and results in one or more of: 1) intratumoral signal intensity (SI) loss using fat-suppression techniques, or 2) chemical shift artifact of the second kind causing linear or curvilinear India-ink (etching) artifact within or at the periphery of a mass at macroscopic fat-water interfaces. "Macroscopic fat" is most commonly observed in adrenal myelolipoma and renal angiomyolipoma (AML) and only rarely encountered in other adrenal cortical tumors and renal cell carcinomas (RCC).
View Article and Find Full Text PDFExpression of murine muscle-enriched A-type lamin-interacting protein (MLIP) is regulated by tissue-specific alternative transcription start sites.
J Biol Chem
December 2018
From the University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada,
Muscle-enriched lamin-interacting protein () is an alternatively spliced gene whose splicing specificity is dictated by tissue type. MLIP is most abundantly expressed in brain, cardiac, and skeletal muscle. In the present study, we systematically mapped the transcriptional start and stop sites of murine Rapid amplification of cDNA ends (RACE) of transcripts from the brain, heart, and skeletal muscle revealed two transcriptional start sites (TSSs), exon 1a and exon 1b, and only one transcriptional termination site.
View Article and Find Full Text PDFCanadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.
Can J Surg
August 2018
From McMaster University, Hamilton, Ont.
Palliative care needs are everywhere: Where do we begin?
Neurology
July 2018
From The University of Ottawa/The Ottawa Hospital (J.Z.), Canada; and School of Nursing/College of Health and Human Services (B.L.), University of North Carolina-Wilmington.
Objective: This study aimed to determine the prevalence of complementary health approaches (CHAs) specifically for acute complaints in patients assessed in a pediatric emergency department (ED) and factors associated with use.
Methods: A cross-sectional survey was offered to patients between the age of 28 days and 18 years assessed at a tertiary pediatric ED between December 2014 and July 2015. Univariate and multivariate logistic regressions were used to identify variables associated with CHA use.
Building Connections With Patients and Families in the Intensive Care Unit: A Canadian Top-Performer Success Story.
Dimens Crit Care Nurs
November 2018
Debbie Matchett, BScN, RN, is manager of intensive care unit, telemetry, acute stroke unit, and respiratory therapy, Bluewater Health, Sarnia, Ontario, Canada. She is critical care nurse for 33 years and currently manager for critical care at Bluewater Health since 2009. Ms Matchett is an RNAO Best Practice Champion and has completed her bachelor of science in nursing with an interdisciplinary certificate in palliative care nursing from Lakehead and has her Indigenous Cultural Safety Certificate. Michel Haddad, MD, MSc, FRCSC, is medical director of Critical Care Program, Bluewater Health, Sarnia, Ontario, and adjunct professor at the University of Western Ontario, London, Canada. Originally from London, Ontario, Canada, Dr Haddad completed his medical school and surgical training at the University of Ottawa, with extra fellowship training in both heart failure surgery at the University of Maryland and Critical Care Medicine at Western University. In addition, he holds a master of science degree in epidemiology from the University of Ottawa. He joined the professional staff at Bluewater Health in 2010 as the medical director of critical care before becoming the medical director of medicine programs, then chief of professional staff in 2016. Prior to joining Bluewater Health, he was practicing as a cardiac surgeon and director of the cardiovascular intensive care unit at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania. Dr Haddad also serves as the academic lead for Western University in Sarnia-Lambton, Ontario, Canada. Dr Haddad has a long track record in research including multiple peer-reviewed scientific publications and book chapters in the fields of cardiothoracic surgery, transplantation, and critical care medicine. Jennifer Volland, DHA, MBE, BSN, RN, is vice president of Program Development, NRC Health where she has oversight of multiple service line improvement programs and harvesting best practices for the acute and post-acute care settings across the US and Canada. Dr Volland regularly speaks at national conferences and publishes in peer-review publications, coaches senior leadership on aligning and implementing initiatives that drive results, and helps organizations to tactically shift their culture to being a high-performing organization with greater consumer loyalty. With over 22 years in nursing, Dr Volland has worked all areas of healthcare either as an Administrator or in a front-line capacity.
Consumers are increasingly becoming the voice and impetus for hospital organizational change in the United States. This is in part due to their increased stake in cost sharing with hospitals, health systems, and the ambulatory setting and revisions to health plans with higher deductibles and copays. With customers wanting services better, faster, and more economical than in the past, organizations need to break the ceiling on improvement levels for exceeding expectations of patient experience.
View Article and Find Full Text PDFEffect of patient decision aid was influenced by presurgical evaluation among patients with osteoarthritis of the knee.
Can J Surg
February 2018
From the University of Ottawa, Ottawa, Ont. (Boland, Tugwell, Stacey); the Patient Decision Aid Research Group, Ottawa Hospital Research Institute, Ottawa, Ont. (Boland, Dervin, Trenaman, Stacey); the Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ont. (Taljaard); the School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ont. (Taljaard); the Ottawa Hospital Research Institute, Ottawa, Ont. (Dervin, Tugwell); the University of British Columbia, Vancouver, BC (Trenaman); and the School of Public Health, University of Montréal, Montréal, Que. (Pomey).
Background: Decision aids help patients make total joint arthroplasty decisions, but presurgical evaluation might influence the effects of a decision aid. We compared the effects of a decision aid among patients considering total knee arthroplasty at 2 surgical screening clinics with different evaluation processes.
Methods: We performed a subgroup analysis of a randomized controlled trial.