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From the Transfusion Research Center[Af... Publications | LitMetric
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Psoralen and Ultraviolet A Light Treatment Directly Affects Phosphatidylinositol 3-Kinase Signal Transduction by Altering Plasma Membrane Packing.

J Biol Chem

November 2016

From the Transfusion Research Center, Belgian Red Cross-Flanders, 9000 Ghent, Belgium,. Electronic address:

Britt Van Aelst Rosalie Devloo Pierre Zachée Ruben t'Kindt Koen Sandra

Psoralen and ultraviolet A light (PUVA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft-versus-host disease. DNA damage is well described, but the direct effects of PUVA on cell signal transduction are poorly understood. Because platelets are anucleate and contain archetypal signal transduction machinery, they are ideally suited to address this.

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