26 results match your criteria: "From the Service Hospitalier Frédéric Joliot-CEA[Affiliation]"

Introduction: Recent evidence suggests the blood-to-brain influx rate ( ) in imaging as a promising biomarker of blood-brain barrier () permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental modeling quantification is limited by the requirement of invasive and laborious procedures for extracting an arterial blood input function. In this study, we validate a simplified blood-free methodologic framework for estimation by fitting the early phase tracer dynamics using a single irreversible compartment model and an image-derived input function ().

View Article and Find Full Text PDF

Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks.

Acta Neuropathol Commun

June 2024

INSERM, CNRS, Institute of Molecular and Cellular Pharmacology, Laboratory of Excellence DistALZ, Université Côte d'Azur, 660 Route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

Article Synopsis
  • - Mitochondrial dysfunctions are prominent in Alzheimer's disease (AD), and their effects on peripheral cells in patients are not well understood, prompting this study focusing on fibroblasts from both healthy volunteers and AD patients at different stages.
  • - Researchers examined mitochondrial structure, function, and mitophagy, correlating findings with cognitive tests (MMSE, CDR-SOB), amyloid beta plaque levels, and peripheral amyloid precursor protein fragments.
  • - The study found mitochondrial alterations and dysfunctions linked to cognitive decline and other AD-related symptoms, highlighting the importance of peripheral cells in AD research.
View Article and Find Full Text PDF

Background: The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages of Alzheimer's disease (AD). Little is known about LC and NBM alteration in limbic-predominant age-related TDP-43 encephalopathy (LATE) and frontotemporal dementia (FTD). The aim of the present study is to investigate in vivo LC and NBM integrity in patients with suspected-LATE, early-amnestic AD and FTD in comparison with controls.

View Article and Find Full Text PDF

Purpose: To assess the likely pathogenic/pathogenic (LP/P) variants rates in Mendelian dementia genes and the moderate-to-strong risk factors rates in patients with Alzheimer disease (AD).

Methods: We included 700 patients in a prospective study and performed exome sequencing. A panel of 28 Mendelian and 6 risk-factor genes was interpreted and returned to patients.

View Article and Find Full Text PDF
Article Synopsis
  • There is a lack of research on psychiatric emergencies in older adults over 60, especially in Europe, prompting a study at a major French psychiatric emergency center.
  • The study involved 300 older patients, predominantly women, many with a history of psychiatric issues, commonly presenting with depression, anxiety, and suicidal thoughts.
  • Findings indicated that 39% of these patients were hospitalized, with factors like past hospitalizations, suicidal tendencies, and certain psychiatric diagnoses being key predictors of hospitalization.
View Article and Find Full Text PDF

Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer's disease? A 2-year longitudinal study.

Alzheimers Res Ther

May 2023

Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte Anne, 75014, Paris, France.

Background: Monitoring the progression of Tau pathology makes it possible to study the clinical diversity of Alzheimer's disease. In this 2-year longitudinal PET study, we aimed to determine the progression of [F]-flortaucipir binding and of cortical atrophy, and their relationships with cognitive decline.

Methods: Twenty-seven AD patients at the mild cognitive impairment/mild dementia stages and twelve amyloid-negative controls underwent a neuropsychological assessment, 3 T brain MRI, and [F]-flortaucipir PET imaging (Tau1) and were monitored annually over 2 years with a second brain MRI and tau-PET imaging after 2 years (Tau2).

View Article and Find Full Text PDF

Increased plasma DYRK1A with aging may protect against neurodegenerative diseases.

Transl Psychiatry

April 2023

Paris Brain Institute (ICM), Centre National de la Recherche Scientifique (CNRS) UMR 7225, INSERM U1127, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, 75013, France.

Early markers are needed for more effective prevention of Alzheimer's disease. We previously showed that individuals with Alzheimer's disease have decreased plasma DYRK1A levels compared to controls. We assessed DYRK1A in the plasma of cognitively healthy elderly volunteers, individuals with either Alzheimer's disease (AD), tauopathies or Down syndrome (DS), and in lymphoblastoids from individuals with DS.

View Article and Find Full Text PDF

Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairment.

Transl Psychiatry

February 2023

ICM Paris Brain Institute, CNRS UMR7225, INSERM U1127, Sorbonne University, Hôpital de la Pitié-Salpêtrière, 47 Bd de l'Hôpital, 75013, Paris, France.

Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimer's disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for AD. Immunostaining with antibodies against endosomal markers such as Early Endosome Antigen 1 (EEA1) revealed increased size of EEA1-positive puncta. In DS, peripheral cells such as peripheral blood mononuclear cells (PBMCs) and fibroblasts, share similar phenotype even in the absence of AD.

View Article and Find Full Text PDF

Purpose: The aim of this study was to compare the diagnostic performance of the rabbit visual pattern versus the one endorsed by the EANM/SNMMI for the diagnosis of parkinsonian syndromes in PET/MRI.

Patients And Methods: The 18F-DOPA PET images of 129 consecutive patients (65 Park+ and 64 controls) with 1 year of clinical follow-up were reviewed independently by 5 experienced readers on the same imaging workstation, blinded to the final clinical diagnosis. Two visual methods were assessed independently, with several days to months of interval: the criteria endorsed by EANM/SNMMI and the "rabbit" shape of the striate assessed on 3D MIP images.

View Article and Find Full Text PDF

Primary CNS lymphoma of the corpus callosum: presentation and neurocognitive outcomes.

J Neurooncol

May 2022

Neurologie 2, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Sorbonne Université, IHU, ICM, Paris, France.

Introduction: The corpus callosum (CC) is frequently involved in primary central nervous system lymphomas (PCNSLs). In this cohort study, we described the neurocognition of patients with PCNSL-CC and its posttherapeutic evolution.

Methods: Immunocompetent patients with PCNSL-CC were identified retrospectively at the Pitié-Salpêtrière Hospital.

View Article and Find Full Text PDF

Tau-PET imaging predicts cognitive decline and brain atrophy progression in early Alzheimer's disease.

J Neurol Neurosurg Psychiatry

May 2022

Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Paris, France.

Article Synopsis
  • The study aims to investigate the relationship between regional tau binding at baseline and the speed of Alzheimer's disease progression over two years, focusing on cognitive decline and brain atrophy.
  • Thirty-six Alzheimer's patients and 15 controls underwent various assessments, including MRIs and PET scans, and were monitored annually to analyze the connections between tau-PET, amyloid-PET, CSF biomarkers, and cognitive decline.
  • The findings indicate that baseline tau-PET is strongly linked to cognitive decline in specific brain regions, highlighting the potential for tau binding as a predictive measure for disease progression and the development of new prognostic markers for therapeutic trials.
View Article and Find Full Text PDF

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.

JAMA Neurol

March 2022

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Article Synopsis
  • The study investigates the prevalence of amyloid aggregation, a key feature of Alzheimer's disease, in individuals with varying cognitive statuses, including those with normal cognition and who have clinical AD dementia.
  • It analyzes how factors like age, sex, educational background, and the method of detecting amyloid (CSF or PET scans) influence the prevalence estimates.
  • Data were collected from 85 study cohorts between 2013 and 2020, using a systematic approach to categorize amyloid measurements as normal or abnormal.
View Article and Find Full Text PDF

We aimed to investigate the amyloid and tau PET imaging signatures of patients with amnestic syndrome of the hippocampal type (ASHT) and study their clinical and imaging progression according to their initial PET imaging status. Thirty-six patients with a progressive ASHT and 30 controls underwent a complete neuropsychological assessment, 3 T brain MRI, [C]-PiB and [F]-Flortaucipir PET imaging. Subjects were clinically followed-up annually over 2 years, with a second 3 T MRI (n = 27 ASHT patients, n = 28 controls) and tau-PET (n = 20 ASHT patients) at the last visit.

View Article and Find Full Text PDF

PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology.

Int J Mol Sci

April 2021

Department of Biophysics and Nuclear Medicine-Molecular Imaging, Hôpitaux Universitaires Paris Saclay, Assistance Publique-Hôpitaux de Paris, CHU Bicêtre, 94270 Le Kremlin-Bicêtre, France.

PET/CT molecular imaging has been imposed in clinical oncological practice over the past 20 years, driven by its two well-grounded foundations: quantification and radiolabeled molecular probe vectorization. From basic visual interpretation to more sophisticated full kinetic modeling, PET technology provides a unique opportunity to characterize various biological processes with different levels of analysis. In clinical practice, many efforts have been made during the last two decades to standardize image analyses at the international level, but advanced metrics are still under use in practice.

View Article and Find Full Text PDF

[The American opioid overdose crisis: A threat for France?].

Rev Med Interne

June 2019

Fédération de toxicologie FeTox, hôpital Lariboisière/Fernand-Widal, AP-HP, 75010 Paris, France; Inserm UMRS 1144, 4, avenue de l'Observatoire, 75006 Paris, France; Université Paris-Diderot, 75013 Paris, France; Réanimation médicale et toxicologique, hôpital Lariboisière, 2, rue Ambroise-Paré, Paris, France.

Since the 2000s, a concerning increase in opioid-analgesic-related overdoses and deaths has been reported in the United States. In contrast with opioid overdoses reported in the 80-90s mostly involving heroin, currently it is the misuse of opioid analgesics that is mainly responsible for opioid overdoses. This crisis is related to factors (not limited to the US) which occurred during the 90s and which have led to a broad prescription of opioids in non-cancer pain.

View Article and Find Full Text PDF

The neural bases of prosopagnosia and pure alexia: recent insights from functional neuroimaging.

Curr Opin Neurol

August 2006

Institut National de la Santé et de la Recherche Médicale, Unit 562, Service Hospitalier Frederic Joliot CEA, Orsay, France.

Purpose Of Review: To discuss whether recent functional neuroimaging results can account for clinical phenomenology in visual associative agnosias.

Recent Findings: Functional neuroimaging studies in healthy human subjects have identified only two regions of ventral occipitotemporal cortex that invariantly respond to individual faces and visual words, respectively. The signature of face identity coding in the fusiform neural response was shown to be missing in a patient with prosopagnosia.

View Article and Find Full Text PDF

At the intersection of two intensely belabored fields, primary visual cortex (V1) function and neural mechanisms of cognitive control, Jack et al. (in this issue of Neuron) report a neural signal that is neither related to stimulus representation nor spatial attention. Instead, this endogenous signal correlates with task structure and raises new questions.

View Article and Find Full Text PDF

The Functional Imaging Analysis Contest (FIAC) culminated in the FIAC Workshop held at the 11th Annual Meeting of the Organization for Human Brain Mapping in Toronto in 2005. This special issue summarizes various analyses used by contestants with a single functional magnetic resonance imaging (fMRI) study, a cortical-language study using sentence repetition. The results from the cognitive neuroscientists who developed the test-base language study, and report their data analysis, are complemented by expert analyses of the same test-base data by most of the major groups actively developing fMRI software packages.

View Article and Find Full Text PDF

Oligonucleotides as radiopharmaceuticals.

Ernst Schering Res Found Workshop

January 2005

INSERM ERM 103 Service Hospitalier, Frédéric Joliot CEA Direction des Sciences du Vivant Direction de la Recherche Medicale, Orsay, France.

View Article and Find Full Text PDF

Synaptic vesicle protein 2 is an integral synaptic vesicle membrane glycoprotein which is present in all synapses for which it has been examined. We used an anti-synaptic vesicle protein 2 monoclonal antibody to examine synaptic vesicle protein 2 localization in the developing hamster retinofugal pathway. From postnatal day 0 to day 1, a period of elongation of retinal ganglion cell axons to their central targets, fiber fascicles in the optic tract over the lateral geniculate nucleus were intensely synaptic vesicle protein 2-immunoreactive.

View Article and Find Full Text PDF

Most nuclear medicine departments possess one or more imaging apparatuses for single-photon emission tomography (SPET). Molecules of biological interest to assess metabolism and receptor function are often labelled with 123I, which allows proper SPET imaging. The various methods for radiolabelling are reviewed.

View Article and Find Full Text PDF

Nuclear Medicine is the application of radioactive materials to the diagnosis and treatment of patients and the study of human disease. The field had its beginning with the discovery of radioactivity by H. Becquerel in 1896 and the tracer principle proposed in 1913 by G.

View Article and Find Full Text PDF

This study evaluated the pain-related behaviours induced by 2 models of peripheral sciatic nerve injuries in the rat: transient nerve crush and chronic constriction injury (CCI). Various lesions of the saphenous nerve were performed in order to investigate the role of saphenous innervation in behavioural disorders induced by these nerve injuries. Behavioural testing included assessment of responses to phasic stimulation (mechanical and thermal) and observation of 'spontaneous' pain-related behaviour.

View Article and Find Full Text PDF

Simultaneous PET measurement of the regional cerebral blood flow (CBF), oxygen extraction (EO2) and cerebral oxygen consumption (CMRO2) demonstrated two important points for the therapeutic management of cerebral ischaemic accidents (CIA): very rapid alterations of the haemodynamic state (CBF and EO2) and the tissue consequences (CMRO2) to the acute phase of CIA and the considerable pathophysiological heterogeneity of these consequences. These two points explain the difficulties encountered in the development of anti-ischaemic treatments. They show the necessity of developing simple techniques which would allow real-time monitoring of cerebral haemodynamics and the development of lesions following CIA.

View Article and Find Full Text PDF

We studied the modifications occurring in the parent cytoskeleton carried by SCa (the slower of the two slow axonal transport subcomponents) after peripheral nerve crush. The proteins transported in rat sciatic motor axons were radiolabelled by injecting [35S]methionine into the ventral horn of the spinal cord, and the nerve was crushed so as to entrap only the proteins transported by SCa along the parent axon. Two weeks after the crush, the regenerating nerve was removed and the distributions of the polymerized and unpolymerized radiolabelled cytoskeletal proteins were compared with those in normal, non-regenerating nerves.

View Article and Find Full Text PDF