Who are the 10%? - Non eligibility of cystic fibrosis (CF) patients for highly effective modulator therapies.

Background: The availability of mutation-specific cystic fibrosis modulator therapies has the potential to improve the lives of children and adults with cystic fibrosis. The frequency of mutations causing defects in the cystic fibrosis transmembrane conductance regulator (CFTR) function varies between sub-groups in multi-ethnic populations. The profile of patients eligible for CFTR modulator ivacaftor/tezacaftor/elexacaftor (Kaftrio™) therapy based on ethnicity has not been reported in the United Kingdom CF population.

Incidence of numerical variants and transitional lumbosacral vertebrae on whole-spine MRI.

Objectives: This study sets out to prospectively investigate the incidence of transitional vertebrae and numerical variants of the spine.

Materials And Methods: Over a period of 28 months, MRIs of the whole spine were prospectively evaluated for the presence of transitional lumbosacral vertebrae and numerical variants of the spine.

Results: MRI of the whole spine was evaluated in 420 patients, comprising 211 female and 209 male subjects.

Magnetic resonance imaging of appendicular musculoskeletal infection.

Appendicular skeletal infection includes osseous and extraosseous infections. Skeletal infection needs early diagnosis and appropriate management to prevent long-term morbidity. Magnetic resonance imaging is the best imaging modality to diagnose skeletal infection early in most circumstances.