2 results match your criteria: "From the National Center for Scientific Research Demokritos[Affiliation]"
Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2.
J Biol Chem
October 2015
From the National Center for Scientific Research Demokritos, Agia Paraskevi, Athens 15310, Greece
Endoplasmic reticulum (ER) aminopeptidases process antigenic peptide precursors to generate epitopes for presentation by MHC class I molecules and help shape the antigenic peptide repertoire and cytotoxic T-cell responses. To perform this function, ER aminopeptidases have to recognize and process a vast variety of peptide sequences. To understand how these enzymes recognize substrates, we determined crystal structures of ER aminopeptidase 2 (ERAP2) in complex with a substrate analogue and a peptidic product to 2.
View Article and Find Full Text PDFImpaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis.
J Rheumatol
September 2015
From the National Center for Scientific Research Demokritos, Agia Paraskevi, Athens; University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas, Heraklion, Crete; Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.C. Gkolfinopoulou, MSc; E. Stratikos, PhD, National Center for Scientific Research Demokritos; D. Theofilatos, MSc; D. Kardassis, PhD, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology of Hellas; P.V. Voulgari, MD, PhD; A.A. Drosos, MD, FACR, Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina; A. Chroni, PhD, National Center for Scientific Research Demokritos.
Objective: Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with increased risk of cardiovascular disease (CVD). High-density lipoprotein (HDL) exerts a series of antiatherogenic properties and protects from CVD. We evaluated whether HDL antiatherogenic properties are impaired in patients with AS.
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