40 results match your criteria: "From the Institute of Neuroscience[Affiliation]"
Clinical and Neurophysiologic Phenotypes in Neonates With Encephalopathy.
Neurology
March 2023
From the Institute Of NeuroScience (E.C., M.R.C.), Université Catholique de Louvain, Brussels, Belgium; Department of Pediatrics (M.-C.C.), University of California, San Francisco; Department of Pediatric Neurology (M.M.), Hôpital "La Timone" Enfants, Institut National de la santé et de la Recherche Médicale, Faculté des Sciences Médicales et Paramédicales de la Timone, Aix-Marseille Université, Marseille, France; Department of Neonatology and Neonatal Intensive Care Unit (L.D.C.), Università Degli Studi di Bari Aldo Moro, Italy; Division of Neuropathology (E.J.H.), Department of Pathology, University of California, San Francisco; Department of Pediatric Neuroscience (T.G., R.S.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) (P.S., G.D.O.), Università Degli studi di Genova, Italy; IRCCS Istituto Giannina Gaslini (P.S.), Università Degli studi di Genova, Italy; Division of Paediatric Neurology (Berten Ceulemans), Department of Pediatrics, Universitair Ziekenhuis Antwerpen, Universiteit Antwerpen, Antwerp, Belgium; Division of Neonatology (A.S.), Department of Pediatrics, Universitätsklinikum Essen, Universität Duisburg-Essen, Germany; Clinical Genetics and Genomics Laboratory (D.M.-R.), Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; NHLI (D.M.-R.), Imperial College London, United Kingdom; Department of Pediatric Neurology (G.C., R.G.), Meyer Azienda Ospedaliero Universitaria Meyer, Università Degli Studi di Firenze, Florence, Italy; Neonatal Intensive Care Unit (N.M.), Cambridge University Hospitals, Cambridge, United Kingdom; Department of Medical Genetics (F.L.R., D.H.R.), Cambridge Institute of Medical Research, University of Cambridge, United Kingdom; Division of Neonatology (D.H.R.), Department of Pediatrics, University of California, San Francisco; Child Neuropsychiatry Unit (F.V.), SS Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy; Department of Neuroscience (P.D.L.), Ospedale Pediatrico Bambino Gesù IRCCS, Rome, Italy; Division of Pediatric Neurology and Neurophysiology (C.B.), Department of Women's and Children's Health, Università Degli Studi di Padova, Italy; Division of Neonatology (O.D., K.C.), Department of Pediatrics, Cliniques Universitaires Saint-Luc, Brussels, Belgium; UCL Queen Square Institute of Neurology (V.S.), London, United Kingdom; The National Hospital for Neurology and Neurosurgery (V.S.), London, United Kingdom; Department of Neurology (S.W.), Universitair Ziekenhuis Antwerpen, Universiteit Antwerpen, Antwerp, Belgium; Applied&Translational Neurogenomics Group (S.W.), VIB Center for Molecular Neurology, Antwerp, Belgium; Translational Neurosciences (S.W.), Faculty of Medicine and Health Science, Universiteit Antwerpen, Belgium; Department of Cardiac, Thoracic, Vascular Sciences, and Public Health (M.F., A.A.), Università Degli Studi di Padova, Italy; Department of Medical Genetics and Neurogenetics (Barbara Castellotti), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Department of Human Genetics (D.L., V.B.), Institut de Pathologie et de Génétique, Charleroi, Belgium; Hospital Neuropsychiatry Service (F.R.), ASST Rhodense, Rho, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (R.D.), Department of Clinical Neurophysiology, Milan, Italy; and Division of Pediatric Neurology (M.R.C.), Department of Pediatrics, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Background And Objectives: encephalopathy is an ultra-rare autosomal recessive neonatal encephalopathy. We delineate the neonatal electroclinical phenotype at presentation and provide insights for early diagnosis.
Methods: Through a multinational collaborative, we studied a cohort of neonates with encephalopathy associated with biallelic pathogenic variants in for whom detailed clinical, neurophysiologic, and neuroimaging information was available from the onset of symptoms.
Associations of Prestroke Physical Activity With Stroke Severity and Mortality After Intracerebral Hemorrhage Compared With Ischemic Stroke.
Neurology
November 2022
From the Institute of Neuroscience and Physiology (A.V., D.B., M.R., A.D., A.P., K.S.S.), Rehabilitation Medicine, Sahlgrenska Academy, University of Gothenburg, and the Sahlgrenska University Hospital; Department of Occupational Therapy and Physiotherapy (M.R.), Sahlgrenska University Hospital; Institute of Neuroscience and Physiology (A.D.), Department of Health and Rehabilitation, Sahlgrenska Academy, University of Gothenburg; and School of Health and Welfare (A.P.), Dalarna University, Falun, Sweden.
Background And Objectives: Prestroke physical activity may protect the brain from severe consequences of stroke. However, previous studies on this subject included mainly ischemic stroke cases, and the association between prestroke physical activity and outcomes after intracerebral hemorrhage is uncertain. Therefore, we sought to examine the associations between prestroke physical activity, stroke severity, and all-cause mortality after intracerebral hemorrhage in comparison with ischemic stroke.
View Article and Find Full Text PDFAssociation of Plasma Biomarker Levels With Their CSF Concentration and the Number and Severity of Concussions in Professional Athletes.
Neurology
July 2022
From the Institute of Neuroscience and Physiology (P.S., H.Z., J.S., N.J.A., M.S., K.B.), Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., H.Z., J.S., N.J.A., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Rehabilitation Medicine Department (P.S.), National Institutes of Health Clinical Center, Bethesda, MD; Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, United Kingdom; UK Dementia Research Institute (H.Z.), London; Wallenberg Centre for Molecular and Translational Medicine (N.J.A., M.S.), University of Gothenburg, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), United Kingdom; Clinical Trials Unit (G.N.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Division of Health (Y.T.), Medicine and Rehabilitation, Department of Health Science, Luleå University of Technology, Sweden; and Department of Neurology (R.D.-A.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
Background And Objectives: To examine whether the brain biomarkers total-tau (T-tau), glial fibrillary acidic protein (GFAP), and β-amyloid (Aβ) isomers 40 and 42 in plasma relate to the corresponding concentrations in CSF, blood-brain barrier integrity, and duration of postconcussion syndrome (PCS) due to repetitive head impacts (RHIs) in professional athletes.
Method: In this cross-sectional study, professional athletes with persistent PCS due to RHI (median of 1.5 years after recent concussion) and uninjured controls were assessed with blood and CSF sampling.
Risk of Recurrent Stroke: The Critical Need for Continued Efforts in Secondary Prevention.
Neurology
January 2022
From the Institute of Neuroscience and Physiology (I.S.), Center for Ageing and Health, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Emergency Medicine (T.E.M.), Alpert Medical School of Brown University; and Department of Epidemiology (T.E.M.), Brown University School of Public Health, Providence, RI.
Atrial Fibrillation, Stroke, and Silent Cerebrovascular Disease: A Population-based MRI Study.
Neurology
October 2021
From the Institute of Neuroscience and Physiology (L.R., S.Sacuiu, H.W., J.N., X.G., S.K., A.Z., I.S.), Sahlgrenska Academy, Centre for Ageing and Health at the University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (L.R., S.S., J.N., S.K., I.S.), Sahlgrenska University Hospital, Region Västra Götaland, Mölndal; Department of Mood Disorders (X.G.), Sahlgrenska University Hospital, Region Västra Götaland, Göteborg; Division of Clinical Geriatrics (S.Shams, J.B.P., L.-O.W., E.W.), Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden; Department of Radiology (S.S.), Stanford, CA; and Clinical Memory Research Unit (J.B.P.), Department of Clinical Sciences, Malmö, Lund University, Sweden.
Background And Objectives: Atrial fibrillation (AF) has been associated with cognitive decline and dementia. However, the mechanisms behind these associations are not clear. Examination of cerebrovascular pathology on MRI may shed light on how AF affects the brain.
View Article and Find Full Text PDFConnecting Upper Limb Functional Stroke Recovery to Global Disability Measures: Finding the Forest in the Trees.
Neurology
April 2021
From the Institute of Neuroscience & Psychology (K.W.M.), University of Glasgow, Queen Elizabeth University Hospital, Scotland, UK; and Department of Neurology (J.J.M.), University of Utah, Salt Lake City.
Epilepsy after brain infection in adults: A register-based population-wide study.
Neurology
December 2020
From the Institute of Neuroscience and Physiology, Department of Clinical Neuroscience (J.Z.), and Department of Neurology (J.Z.), Sahlgrenska Academy, and Wallenberg Center of Molecular and Translational Medicine (J.Z.), Gothenburg University; and Department of Medical Sciences (G.W.), Section of Infectious Diseases, Uppsala University, Sweden.
Objective: To describe risk and risk factors of epilepsy after hospitalization for brain infection in adults in Sweden.
Methods: This was a matched retrospective cohort study based on the comprehensive National Patient and Cause of Death Registers. All individuals age >18 without prior epilepsy who received inpatient care in 2000-2010 for a brain infection were included, with 3 age- and sex-matched unexposed controls per exposed individual (n = 12,101 exposed and 36,228 controls).
Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke.
Stroke
November 2019
From the Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, Scotland (S.E.-T., K.W.M.).
Background and Purpose- Computed tomography (CT) perfusion (CTP) provides potentially valuable information to guide treatment decisions in acute stroke. Assessment of interobserver reliability of CTP has, however, been limited to small, mostly single center studies. We performed a large, internet-based study to assess observer reliability of CTP interpretation in acute stroke.
View Article and Find Full Text PDFEpilepsy duration and seizure outcome in epilepsy surgery: A systematic review and meta-analysis.
Neurology
July 2019
From the Institute of Neuroscience and Physiology, Department of Clinical Neuroscience (J.B., K.M.), and Institute of Clinical Sciences, Department of Paediatrics (I.O.), Sahlgrenska Academy, University of Gothenburg, and Sahlgrenska University Hospital, Gothenburg; and Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) (K.W.R.), Stockholm, Sweden.
Objective: To conduct a systematic review and meta-analysis on the effect of earlier or later resective epilepsy surgery on seizure outcome.
Methods: We searched the electronic databases PubMed, EMBASE, and Cochrane Library for studies investigating the association of epilepsy duration and seizure freedom after resective surgery. Two reviewers independently screened citations for eligibility and assessed relevant studies for risk of bias.
Perfusion imaging INSPIREs precision medicine in stroke.
Neurology
June 2019
From the Institute of Neuroscience & Psychology (K.W.M.), University of Glasgow, Queen Elizabeth University Hospital, UK; and Neurointervention Service (B.Y.), Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
Do Clinicians Overestimate the Severity of Intracerebral Hemorrhage?
Stroke
February 2019
From the Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Scotland, UK.
Background and Purpose- Intracerebral hemorrhage (ICH) has a poorer prognosis than acute ischemic stroke (AIS). However, clinician perception of prognosis may influence treatment decisions and adversely affect outcome. On acute CT, the conspicuity of ICH compared with AIS may lead clinicians to overestimate severity and influence prognostic evaluation.
View Article and Find Full Text PDFReduced occipital GABA in Parkinson disease with visual hallucinations.
Neurology
August 2018
From the Institute of Neuroscience (M.J.F., A.K., C.L.A., D.C., J.-P.T.), Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne; and Newcastle Magnetic Resonance Centre (J.P., A.M.B.), Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK; and Baylor College of Medicine (N.M.), Houston, TX.
Objective: To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex.
Methods: We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex visual hallucinations, together with 20 healthy controls without hallucinations. In addition, we acquired T1-weighted MRI, whole-brain fMRI during a visual task, and diffusion tensor imaging.
Neurofilament light and tau as blood biomarkers for sports-related concussion.
Neurology
May 2018
From the Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (P.S., K.B., H.Z.), the Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., K.B., H.Z.), Sahlgrenska University Hospital, Mölndal; Division of Medical Sciences, Department of Health Sciences (P.S.), Luleå University of Technology; Department of Clinical Sciences (Y.T.), Skåne University Hospital, Lund University, Sweden; Department of Neurology (N.M.), Washington University School of Medicine, St. Louis, MO; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square; and UK Dementia Research Institute (H.Z.), London.
Objective: To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP).
Methods: A total of 288 professional hockey players were followed longitudinally from September 1, 2012, to April 30, 2015. Data collection and biomarker analyses were conducted between 2015 and 2017.
The captive brain: torture and the neuroscience of humane interrogation.
QJM
February 2018
From the Institute of Neuroscience, Trinity College, Dublin D02 PN40, Ireland.
Despite it being abhorrent and illegal, torture is sometimes employed for information gathering. However, the extreme stressors employed during torture force the brain away from the relatively narrow, adaptive range of function it operates within. Torture degrades signal-to-noise ratios of information yield and increases false positive discovery rates.
View Article and Find Full Text PDFSerum neurofilament light as a biomarker for mild traumatic brain injury in contact sports.
Neurology
May 2017
From the Institute of Neuroscience and Physiology (P.S., H.Z., K.B.), Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and the Division of Medical Sciences (Y.T.), Department of Health Sciences, Luleå University of Technology, Sweden.
Objective: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes.
Methods: Two prospective cohort studies involving (1) 14 Swedish amateur boxers who underwent fluid biomarker assessments at 7-10 days after bout and after 3 months of rest from boxing and (2) 35 Swedish professional hockey players who underwent blood biomarker assessment at 1, 12, 36, and 144 hours after concussion and when the players returned to play were performed. Fourteen healthy nonathletic controls and 12 athletic controls were also enrolled.
Decrease in Aβ42 predicts dopa-resistant gait progression in early Parkinson disease.
Neurology
April 2017
From the Institute of Neuroscience (L.R., B.G., S.L., A.J.Y., R.M., G.D., T.K.K., D.J.B.), Clinical Ageing Research Unit, Newcastle University; Department of Geriatric Medicine (G.D.), University of Edinburgh, UK; School of Medicine & Menzies Health Institute (T.K.K.), Griffith University, Australia; and Paracelsus-Elena Klinik, Kassel and University Medical Centre (Institute of Neuropathology and Department of Neurosurgery) (B.M.), Göttingen, Germany.
Objective: This prospective observational study investigates the role of CSF biomarkers in predicting progression of dopa-resistant gait impairments in Parkinson disease (PD) in the first 36 months from diagnosis.
Methods: Quantitative gait analysis was carried out longitudinally using an instrumented walkway (GAITRite) in 108 people with PD and 130 age-matched controls. A subgroup of 44 people with PD underwent lumbar puncture from which a battery of CSF biomarkers was measured: β-amyloid 1-42 and 1-40 (Aβ42 and Aβ40), total and phosphorylated tau protein (t-tau/p-tau), and α-synuclein (αSyn).
Astroglial activation and altered amyloid metabolism in human repetitive concussion.
Neurology
April 2017
From the Institute of Neuroscience and Physiology (P.S., K.H., E.P., K.B., H.Z.), Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., K.H., E.P., K.B., H.Z.), Sahlgrenska University Hospital, Mölndal; Division of Medical Sciences, Department of Health Sciences (Y.T.), Luleå University of Technology; Department of Neuroscience, Neurosurgery (N.M.), Uppsala University, Uppsala, Sweden; Washington University School of Medicine (D.L.B.), St. Louis, MO; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Objective: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood-brain barrier (BBB) impairment.
Methods: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.
Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.
Neurology
January 2017
From the Institute of Neuroscience (A.J.T., J.A., S.J.C., I.M., D.B., D.J.L.), Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne; Department of Psychiatry (J.T.O.), University of Cambridge School of Clinical Medicine; Department of Neurology (R.W.), Barts Health NHS Trust, Royal London Hospital; North Essex Partnership University NHS Foundation Trust (L.L., Z.W.), Epping; and Division of Psychiatry (Z.W.), University College London, UK.
Objective: To conduct a validation study of I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard.
Methods: Patients >60 years of age with dementia who had undergone I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria.
Cerebral Venous Thrombosis: Epidemiology in Change.
Stroke
September 2016
From the Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden (T.T., K.J.); Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (T.T., K.J.); and Department of Neurology, Helsinki University Hospital, Finland (T.T., J.P.).
Cholinergic and perfusion brain networks in Parkinson disease dementia.
Neurology
July 2016
From the Institute of Neuroscience (S.J.C., I.G.M., D.J.B., J.-P.T.), Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne; SINAPSE (D.J.W.), Institute of Neuroscience and Psychology, University of Glasgow; and Department of Psychiatry (J.T.O.), University of Cambridge, UK.
Objective: To investigate muscarinic M1/M4 cholinergic networks in Parkinson disease dementia (PDD) and their association with changes in Mini-Mental State Examination (MMSE) after 12 weeks of treatment with donepezil.
Methods: Forty-nine participants (25 PDD and 24 elderly controls) underwent (123)I-QNB and (99m)Tc-exametazime SPECT scanning. We implemented voxel principal components (PC) analysis, producing a series of PC images of patterns of interrelated voxels across individuals.
Interaction of Recanalization, Intracerebral Hemorrhage, and Cerebral Edema After Intravenous Thrombolysis.
Stroke
July 2016
From the Institute of Neuroscience and Psychology (B.K.C., X.H., K.W.M.) and Institute of Cardiovascular and Medical Sciences (R.M.), University of Glasgow, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom.
Background And Purpose: Both intracerebral hemorrhage (ICH) and brain edema have been attributed to reperfusion after intravenous thrombolysis. We explored the interaction of recanalization and core size for imaging outcomes (ICH and vasogenic brain edema).
Methods: In patients with anterior circulation occlusion given intravenous thrombolysis <4.
Depression Phenotype, Inflammation, and the Brain: Implications for Future Research.
Psychosom Med
May 2016
From the Institute of Neuroscience and Psychology (Krishnadas), University of Glasgow, Glasgow, United Kingdom; and Department of Neuroscience, Clinical Imaging Sciences Centre (Harrison), Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
Inflammation is implicated in the etiology of major depressive disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to MDD. In this issue of Psychosomatic Medicine, Byrne and colleagues report the first systematic review of these studies.
View Article and Find Full Text PDFVascular factors in suspected normal pressure hydrocephalus: A population-based study.
Neurology
February 2016
From the Institute of Neuroscience and Physiology (D.J., S.A., K.R., T.M., X.G., S.K., C.W., I.S.), Neuropsychiatric Epidemiology Research Unit (D.J., T.M., X.G., S.K., I.S.), Hydrocephalus Research Unit (D.J., S.A., K.R., C.W.), and Institute of Clinical Sciences (C.J.), University of Gothenburg, Sweden.
Objective: We examined clinical and imaging findings of suspected idiopathic normal pressure hydrocephalus (iNPH) in relation to vascular risk factors and white matter lesions (WMLs), using a nested case-control design in a representative, population-based sample.
Methods: From a population-based sample, 1,235 persons aged 70 years or older were examined with CT of the brain between 1986 and 2000. We identified 55 persons with hydrocephalic ventricular enlargement, i.
Medial Prefrontal Aberrations in Major Depressive Disorder Revealed by Cytoarchitectonically Informed Voxel-Based Morphometry.
Am J Psychiatry
March 2016
From the Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany; the Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; the Center for Translational Research in Systems Neuroscience and Psychiatry, Clinic for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany; the Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, the Netherlands; the Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; the Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar, München, Germany; the Department of Neuroradiology, TU München, München, Germany; the Department of Psychiatry, TU München, München, Germany; the Cécile and Oskar Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany; and the Parietal team, INRIA, Neurospin, Gif-sur-Yvette, France; the Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany; and JARA-Translational Brain Medicine, Aachen, Germany.
Objective: The heterogeneous human frontal pole has been identified as a node in the dysfunctional network of major depressive disorder. The contribution of the medial (socio-affective) versus lateral (cognitive) frontal pole to major depression pathogenesis is currently unclear. The authors performed morphometric comparison of the microstructurally informed subdivisions of human frontal pole between depressed patients and comparison subjects using both uni- and multivariate statistics.
View Article and Find Full Text PDFCerebral hyperperfusion on arterial spin labeling MRI during CADASIL migrainous encephalopathy.
Neurology
December 2015
From the Institute of Neuroscience and Psychology, University of Glasgow (F.C.M., K.W.M.), and the Institute of Neurological Sciences (C.S., K.M.), Southern General Hospital, Glasgow, UK.